Grants for Unrestricted - Science and Technology

The FY24 HRRP FRA mechanism is intended to support promising research that accelerates drug discovery and therapeutic development for hearing restoration after military-relevant auditory system injury. Applicants are encouraged to leverage resources and expertise at the National Center for Advancing Translational Sciences (NCATS) to improve efficiency and accelerate the translational process. A list of NCATS programs and resources supporting preclinical innovation can be found at https://ncats.nih.gov/preclinical. Applications from investigators within the military Services and applications involving multidisciplinary collaborations among academia, industry, the military Services, the VA, and other federal government agencies are highly encouraged. These relationships can leverage knowledge, infrastructure, and access to unique clinical populations that the collaborators bring to the research effort, ultimately advancing research that is of significance to Service Members, Veterans, and/or their Families. If the proposed research relies on access to unique resources or databases, the application must describe the access at the time of submission and include a plan for maintaining access as needed throughout the proposed research.

This funding opportunity is designed for research partners in the Pacific Northwest to study the impact of tire-derived chemicals on coho salmon health and survival, particularly in relation to urban runoff pollution.

This funding opportunity is designed to support projects that develop and test new technologies for large-scale carbon storage, targeting organizations and researchers focused on advancing carbon capture and storage solutions to help achieve U.S. decarbonization goals.

This grant provides funding for institutions affiliated with the Cooperative Ecosystem Studies Units to conduct a comprehensive recreational boating survey at Broken Bow Lake in Oklahoma, aimed at improving management and planning for recreational activities.

This program provides funding to innovators developing non-invasive tear-based diagnostic technologies for continuous health monitoring and personalized treatment, initially targeting Dry Eye Disease.

This funding opportunity is designed for partners affiliated with the Colorado Plateau Cooperative Ecosystem Studies Unit to develop advanced camera-based water monitoring technology for the U.S. Geological Survey's national network.

The PRCRP is seeking to advance cancer research through development of early-career investigators. Under this award mechanism, the early-career investigator is considered the Principal Investigator (PI), and the application should focus on the PIs research and career development. Preliminary data are not required. However, logical reasoning and a sound scientific rationale for the proposed research must be demonstrated. This award supports impactful research projects with an emphasis on discovery. The CDA-SO supports an independent, highly accomplished early-career investigator (referred to as a Scholar) to conduct impactful research under the guidance of an experienced cancer researcher (i.e., Career Guide). Scholars are required to participate in the unique, interactive Virtual Cancer Center (VCC) focused on fostering the next generation of cancer researchers. The overarching goal of the VCC is to develop successful, highly productive Scholars in a collaborative research and career developmental environment. The VCC will give Scholars opportunities to operate in a collegial, highly dynamic, and cutting edge research organization to lead cancer research to a new frontier. It is the intention that, through the VCC, collaborations will foster new growth to ensure the research advancements across different cancers. The VCC directorship is awarded through a separate mechanism, the Virtual Cancer Center Directors Award (VCCDA). The VCCDA calls for two established investigators (Director and Deputy Director) to provide intensive mentoring, national networking, collaborations, and a peer group for Scholars. In addition to their Career Guide, Scholars are required to interact with the VCC Director, Deputy Director, and fellow Scholars to include required attendance at in-person meeting with VCC Members annually. The intention of the Scholar Option is to support highly accomplished investigators toward the goal of leadership in cancer. The critical components of the Career Development Award: Principal Investigator: The PI must be an early-career researcher or physician-scientist within 7 years after completion of their terminal degree by the time of the application deadline (excluding time spent in residency, clinical training, or on family medical leave). Time spent as a postdoctoral fellow is not excluded. Postdoctoral fellows are not eligible for this award mechanism. The PIs record of accomplishments and the proposed research will be evaluated regarding their potential for contributing to at least one of the FY24 PRCRP Topic Areas. The Scholar must be in a tenure-track position or equivalent position. The Scholar must demonstrate significant accomplishments, including first-author publications, extramural funding (beyond nominal), and show excellence in cancer research as supported by letters of recommendation. The Scholar must have independent laboratory space separate from the Career Guides laboratory or other mentors laboratory. For more information on the eligibility criteria for the Virtual Cancer Center Scholar Option, refer to Section II.C.1. Career Guide: The Scholar must designate a Career Guide. The Career Guide must be an experienced cancer researcher, as demonstrated by a strong record of funding and publications. In addition, the Career Guide must demonstrate a commitment to advancing the PIs career in cancer research and be committed to fully participating in the VCC and potentially serving on the VCCs Advisory Board as requested by VCC Leadership. Career Development Plan: A career development plan is required and should be prepared with appropriate guidance from the Career Guide. The career development plan should include a clearly articulated strategy for acquiring the necessary skills, competence, further independence, and expertise to advance their career at the forefront of cancer research in at least one of the FY24 PRCRP Topic Areas. Milestones: The Scholar must show career milestones and pathways toward achieving the milestones. The Scholar should demonstrate clear commitment to at least one of the FY24 PRCRP Topic Areas through a career development plan designed to enhance further networking and collaboration. Impact: The applicant must articulate the potential impact the proposed work will have on cancer research and/or patient care. Impactful research will accelerate the movement of promising ideas in cancer research into clinical applications.

Bipartisan Infrastructure Law (BIL) - Clean Fuels Products Shot: Supporting Carbon Utilization Products via Electrochemical Conversion and Refinery and Petrochemical Facilities Retrofitting The Office of Fossil Energy and Carbon Management (FECM) in collaboration with the National Energy Technology Laboratory (NETL) is issuing this Funding Opportunity Announcement (FOA). Awards made under this FOA will be funded, in whole or in part, with funds appropriated by the Infrastructure Investment and Jobs Act, more commonly known as the Bipartisan Infrastructure Law (BIL). The activities to be funded under this Funding Opportunity Announcement support BIL Section 40302. Research and Development funded under this Funding Opportunity Announcement will support the Departments Clean Fuels Products Shots initiative, which was established to support the national goal of achieving net-zero emissions by 2050 by developing the sustainable feedstocks and conversion technologies necessary to produce crucial fuels, materials, and carbon-based products that are better for the environment than current petroleum-derived components. It aims to meet projected 2050 net-zero emissions demands for 100 percent of aviation fuel; 50 percent of maritime, rail, and off-road fuel; and 50 percent of carbon-based chemicals by using sustainable carbon resources. Modification 000001: The purpose of this modification is to update wording within the Topic Area descriptions to clarify the Funding Opportunity Announcement does not restrict conversion of carbon oxides, change instances of "CO2" to "carbon" throughout the Funding Opportunity Announcement, and clarify the medium-term test requirement for Topic Area 1.

The "Carbon Management" grant, offered by the Department of Energy, provides $78.4 million in funding for U.S. organizations to develop and test technologies for capturing, removing, converting, and storing carbon to combat climate change, with applications due by October 14, 2024.

The FY24 ALSRP Clinical Outcomes and Biomarkers Award (COBA) supports the development and/or validation of clinical outcomes and biomarkers to enrich clinical trials in Amyotrophic Lateral Sclerosis (ALS). Projects can be relevant to a specific therapy, a class of therapeutics, or to a specific ALS subtype (such as a particular genetic mutation) and do not have to broadly apply to all patients.Research may include, but is not limited to:Target engagement biomarkers.Objective pharmacodynamic biomarkers to measure the biological effect of an investigational therapeutic.Predictive/cohort-selective biomarkers that indicate whether a specific therapy will be effective in an individual patient or patient subgroup.Diagnostic, prognostic, or disease progressionValidate clinician-, observer-, patient-reported and/or performance outcomes to better support clinical trial success metrics.Define ALS subtypes using patient-based resources to link biosamples and/or digital data elements to rigorous molecular and clinical data.Realize improved strategies that better measure disease progression for people living with ALS.Augment biospecimens, outcome, or digital health data to an on-going clinical trial.Correlate clinical-trial related data (e.g., biosample, imaging, digital health data) with clinical outcomes or responses to therapies.Use of existing well-characterized and highly curated clinical resources is encouraged. Examples of patient-based ALS resources include ongoing or completed clinical trial datasets, biorepositories of clinical specimens, registries (e.g., Centers for Disease Control and Prevention National ALS Registry and/or Biorepository; https://www.cdc.gov/als/Default.html), large omics datasets, patient-report outcomes, digital biomarker datasets, and databases of clinical data and/or metadata. Active-duty military and/or Veteran patient populations or resources should be considered. A list of suitable resources can be found on the ALSRP web page (https://cdmrp.health.mil/alsrp/resources/ALSRPresources). Other resources may be used, provided they have an adequate description of repository parameters and mechanisms for broad access.

This initiative seeks input from researchers and industry stakeholders on innovative technologies to replace traditional heating systems in refineries and petrochemical plants with efficient nuclear heat solutions, aiming to significantly reduce emissions and improve process efficiency.

This grant provides funding for organizations in the Colorado Plateau or Desert Southwest regions to conduct bat surveys and conservation efforts at Fort Carson and the Piñon Canyon Maneuver Site, focusing on protecting species like the tricolored bat from threats such as white-nose syndrome.

This funding opportunity supports collaborative research partnerships among academic institutions, nonprofits, and small businesses in the U.S. to advance scientific innovation and address critical health challenges, particularly for underserved populations.

This funding opportunity is designed to support researchers and companies developing advanced technologies for converting carbon dioxide into useful products, focusing on biological, catalytic, and mineralization methods.

This grant provides funding for research and technology development in weather and atmospheric dynamics, aimed at advancing our understanding of Earth and space sciences.

This funding opportunity is designed for national laboratories to collaborate with industry stakeholders in the chemicals, concrete, and metals sectors to develop and implement strategies that accelerate the commercialization of technologies aimed at reducing industrial carbon emissions.

This funding opportunity is designed for research organizations affiliated with the Colorado Plateau Cooperative Ecosystem Studies Unit to study and improve land management practices that reduce wildfire risks and restore ecosystems in the southwestern United States.

The grant titled "ROSES 2024: C.27 Lucy in the L4 Trojans Participating Scientist Program" is a funding opportunity by NASA's Science Mission Directorate for research and technology in space and Earth sciences, with a specific focus on the Lucy in the L4 Trojans project, and it invites proposals from various types of organizations, both domestic and foreign.

This grant supports researchers in mathematical and statistical sciences to develop innovative tools and theories that address challenges in computation and big data, while fostering collaboration and training for early-career scientists.

This grant provides funding for organizations specializing in cultural resource management to support archaeological surveys and compliance with preservation laws at Joint Base Langley-Eustis in Virginia.