Grants for For profit organizations other than small businesses - Federal

The FY24 PCRP Exploration Hypothesis Development Award supports the exploration of highly innovative, untested, potentially high-gain concepts, theories, paradigms, and/or methods that address an important problem relevant to one or more of the FY24 PCRP Overarching Challenges. This award is designed to provide investigators the opportunity to pursue serendipitous observations that may reveal entirely new avenues for investigation. Results of studies conducted through this award may provide the scientific premise upon which a new hypothesis can be based or initial proof of principle of an innovative hypothesis, laying the groundwork for future avenues of scientific investigation. Presentation of preliminary data is inconsistent with the intent of this award mechanism and is therefore strongly discouraged. However, logical reasoning and a sound scientific rationale for the proposed work must be described. Reviewers will be blinded to the identity of the Principal Investigator (PI), collaborator(s), and their organization(s). Refer to Section II.D.2.b.i, Full Application Submission Type, for more information. New for FY24: Clinical research is allowed. For the purposes of this funding opportunity, research that meets the definition of a clinical trial is distinct from clinical research. Clinical research encompasses research with human data, human specimens, and/or interaction with human subjects. Clinical research is observational in nature and includes: (1) Research conducted with human subjects and/or material of human origin such as data, specimens, and cognitive phenomena for which an investigator (or co-investigator) does not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention. Research meeting this definition may include but is not limited to: (a) mechanisms of human disease, (b) diagnostic or detection studies (e.g., biomarker or imaging), (c) health disparity studies, and (d) development of new technologies. (2) Epidemiologic and behavioral studies that do not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention. (3) Outcomes research and health services research that do not fit under the definition of clinical trial. Excluded from the definition of clinical research are in vitro studies that utilize human data or specimens that cannot be linked to a living individual and meet the requirements for exemption under 46.104(d)(4) of the Common Rule. Clinical trials are not allowed. A clinical trial is defined in the Code of Federal Regulations, Title 45, Part 46.102 (45 CFR 46.102) as a research study in which one or more human subjects are prospectively assigned to one or more interventions (which may include a placebo or another control) to evaluate the effects of the interventions on biomedical or behavioral health-related outcomes. Studies that do not seek to measure safety, effectiveness, and/or efficacy outcome(s) of an intervention are not considered clinical trials. A congressionally mandated Metastatic Cancer Task Force was formed with the purpose of identifying ways to help accelerate clinical and translational research aimed at extending the lives of advanced state and recurrent patients. As a member of the Metastatic Cancer Task Force, the CDMRP encourages applicants to review the recommendations (https://health.mil/Reference-Center/Congressional-Testimonies/2018/05/03/Metastatic-Cancer Research) and submit research ideas to address these recommendations provided they are within the limitations of this funding opportunity and fit within the FY24 PCRP priorities. Innovative research involving nuclear medicine and related techniques to support early diagnosis, more-effective treatment, and improved health outcomes of active-duty Service Members and their Families is encouraged. Such research could improve diagnostic and targeted treatment capabilities through noninvasive techniques and may drive the development of precision imaging and advanced targeted therapies. Applications from investigators within the military services and applications involving multidisciplinary collaborations among academia, industry, the military services, the U.S. Department of Veterans Affairs (VA), and other federal government agencies are highly encouraged. These relationships can leverage knowledge, infrastructure, and access to unique clinical populations that the collaborators bring to the research effort, ultimately advancing research that is of significance to Service Members, Veterans, and/or their Families. If the proposed research relies on access to unique resources or databases, the application must describe the access at the time of submission and include a plan for maintaining access as needed throughout the proposed research. All projects should adhere to a core set of standards for rigorous study design and reporting to maximize the reproducibility and translational potential of clinical and preclinical research. The standards are described in SC Landis et al., 2012, A call for transparent reporting to optimize the predictive value of preclinical research, Nature 490:187-191 (https://www.nature.com/nature/ journal/v490/n7419/full/nature11556.html). While these standards are written for preclinical studies, the basic principles of randomization, blinding, sample-size estimation, and data handling derive from well-established best practices in clinical studies. The funding instrument for awards made under the program announcement will be grants (31 USC 6304). The anticipated direct costs budgeted for the entire period of performance for an FY24 Exploration Hypothesis Development Award should not exceed $150,000. Refer to Section II.D.5, Funding Restrictions, for detailed funding information. Awards supported with FY24 funds will be made no later than September 30, 2025. The CDMRP expects to allot approximately $3.60M to fund approximately 15 Exploration Hypothesis Development Award applications. Funding of applications received is contingent upon the availability of federal funds for this program, the number of applications received, the quality and merit of the applications as evaluated by peer and programmatic review, and the requirements of the government. Funds to be obligated on any award resulting from this funding opportunity will be available for use for a limited time period based on the fiscal year of the funds. It is anticipated that awards made from this FY24 funding opportunity will be funded with FY24 funds, which will expire for use on September 30, 2030. Research Involving Animals: All research funded by the FY24 PCRP Exploration-Hypothesis Development Award involving new and ongoing research with animals must be reviewed and approved by the USAMRDC Office of Human and Animal Research Oversight (OHARO; previously the Human Research Protection Office), Animal Care and Use Review Office (ACURO), in addition to the local Institutional Animal Care and Use Committee (IACUC) of record. IACUC approval at the time of submission is not required. Allow at least 3 to 4 months for ACURO regulatory review and approval processes for animal studies. Refer to the General Application Instructions for additional information.

The United States Agency for International Development in Vietnam (USAID/Vietnam) is seeking applications from qualified entities to implement the "USAID Reducing Pollution" activity. The overall objective of this activity is to reduce environmental pollution in targeted areas through a collective impact approach. The USAID Reducing Pollution project supports Vietnam’s efforts to address environmental pollution challenges in targeted areas through a collective impact approach. Working in close partnership with the Ministry of Natural Resources and Environment’s Vietnam Environment Administration (VEA), the project will demonstrate clear connections between environmental benefits and other social benefits, including public health, employment, and sustainable economic growth. COLLECTIVE IMPACT APPROACH A collective impact approach addresses complex challenges by mobilizing diverse actors to collaborate, identify ways to solve a shared problem, and take action based on their roles and comparative advantages. The USAID Reducing Pollution project will follow the collective impact framework to strengthen networks of local organizations, government, private sector, and academic institutions working together to prevent, mitigate, and reduce environmental pollution. SUPPORTING A PORTFOLIO OF COLLECTIVE IMPACT INITIATIVES The project will facilitate a broad consultative process with local government officials, community leaders, local organizations, and motivated businesses to identify 5-7 priority collective impact initiatives that reflect strong political will, community leadership, and engagement from private sector partners to address environmental pollution challenges. Preliminary consultations have identified air pollution and ocean plastics as areas of focus. GRANT-MAKING TO VIETNAMESE LOCAL ORGANIZATIONS To foster Vietnamese leadership in addressing environmental pollution, the project will make grants to a local organization to serve as the “backbone” for each collective impact initiative. These backbone organizations will serve as the local leaders for each initiative by building public support, advancing policy, leveraging additional funding, and designing and implementing targeted awareness and behavior change campaigns. Additional small grants to local research institutions and community-based organizations will provide targeted support for complementary research and advocacy efforts. EXPECTED RESULTS Through the Reducing Pollution project, USAID expects to attain the following results: 1) 5-7 collective impact initiatives launched, including air pollution and ocean plastics; 2) Grants awarded to one backbone organization to lead each initiative; 3) Capacity of backbone organizations and local actors strengthened to advance collective impact initiatives; 4) Sustainable funding mechanisms identified to strengthen long-term effectiveness of collective impact initiatives; and 5) New policies and guidance developed to support the 2020 Law on Environmental Protection and create a stronger enabling environment for addressing environmental pollution challenges.

To obtain a copy of the Funding Opportunity Announcement (FOA) please go to the ARPA-E website at https://arpa-e-foa.energy.gov. To apply to this FOA, Applicants must register with and submit application materials through ARPA-E eXCHANGE (https://arpa-e-foa.energy.gov/Registration.aspx). For detailed guidance on using ARPA-E eXCHANGE, please refer to the ARPA-E eXCHANGE User Guide (https://arpa-e-foa.energy.gov/Manuals.aspx). ARPA-E will not review or consider concept papers submitted through other means. For problems with ARPA-E eXCHANGE, email [email protected] (with FOA name and number in the subject line). Questions about this FOA? Check the Frequently Asked Questions available at http://arpa-e.energy.gov/faq. For questions that have not already been answered, email [email protected]. The purpose of this modification is to incorporate changes to Funding Opportunity Announcement. Accordingly, this modification: Inserted new Exploratory Topic, Topic M: H2SENSE. See Table 1. Exploratory Topics, Appendix M, and Total Amounts to be awarded on Cover Page. Updated Language in Appendix L Section 5.

Nature crimes, criminal forms of logging, mining, wildlife trade, land conversion, and associated criminal activities, as well as crimes associated with fishing, pose serious threats to the environment and to national security. They undermine the rule of law and fuel corruption. They also spread disease globally, drive species to the brink of extinction, and rob governments, indigenous peoples, and local communities of their natural resources and legitimate revenue. The goal of this program is to increase global grassroot civil society engagement in addressing nature crimes. To advance the policy goal described above, OES seeks one or two lead implementing partners to form consortia with grassroots civil society organizations across various countries to deploy community-led approaches that address global nature crime trends. By taking advantage of the valuable knowledge offered by these partners, OES aims to strengthen their efforts to expose nature crimes, hold perpetrators accountable, reduce profits from these crimes, and support the environment and local livelihoods.

This program provides training and support at no cost to small businesses, particularly those that are socially and economically disadvantaged, to help them compete for federal contracts and grow their operations.

This funding opportunity is designed to support academic and community healthcare organizations in enrolling diverse patient populations in cancer clinical trials, enhancing cancer research in underserved areas.

This funding opportunity supports junior faculty in obstetrics and gynecology who are dedicated to advancing their research careers in women's reproductive health.

This funding opportunity provides financial support to organizations and institutions working to prevent the proliferation of chemical weapons by enhancing partner nations' capabilities in detection, response, and compliance with international norms.

This funding opportunity supports research institutions and organizations in developing a comprehensive study on viral respiratory infections in young children, aiming to improve understanding and treatment of these common illnesses.

This funding opportunity supports research projects that utilize existing datasets to advance understanding of substance use disorders, targeting a wide range of eligible applicants including educational institutions, government entities, and nonprofits.

This funding opportunity supports innovative research projects aimed at improving burn care for military personnel, particularly in combat situations, by addressing unique medical challenges and enhancing treatment methods.

This funding opportunity provides financial support to early-stage postdoctoral researchers dedicated to advancing their careers in cancer research through enhanced training and mentorship.

This funding opportunity supports U.S.-based organizations and educational institutions in conducting innovative research on fluid dynamics, materials, and manufacturing processes in the unique microgravity environment of the International Space Station, with the goal of benefiting life on Earth.

This funding opportunity supports innovative projects aimed at advancing electric vehicle technology and battery development, particularly for teams that include diverse stakeholders and focus on safety, cost reduction, and environmental justice.

Proposers must retrieve the instructions document (zip file) associated with the application package for this opportunity as there is at least one required form that must be attached to the submitted proposal package. The National Aeronautics and Space Administration (NASA) Science Mission Directorate (SMD) released its annual omnibus Research Announcement (NRA), Research Opportunities in Space and Earth Sciences (ROSES) 2024 (OMB Approval Number 2700-0092, CFDA Number 43.001) on February 14, 2024. In this case "omnibus" means that this NRA has many individual program elements, each with its own due dates and topics. All together these cover the wide range of basic and applied supporting research and technology in space and Earth sciences supported by SMD. Awards will be made as grants, cooperative agreements, contracts, and inter- or intra-agency transfers, depending on the nature of the work proposed, the proposing organization, and/or program requirements. However, most extramural research awards deriving from ROSES will be grants, and many program elements of ROSES specifically exclude contracts, because contracts would not be appropriate for the nature of the work solicited. The typical period of performance for an award is three years, but some programs may allow up to five years and others specify shorter periods. In most cases, organizations of every type, Government and private, for profit and not-for-profit, domestic and foreign (with some caveats), may submit proposals without restriction on teaming arrangements. Tables listing the program elements and due dates (Tables 2 and 3), a table that provides a very top level summary of proposal contents (Table 1), and the full text of the ROSES-2024 "Summary of Solicitation", may all be found NSPIRES at http://solicitation.nasaprs.com/ROSES2024. This synopsis is associated with one of the individual program elements within ROSES, but this is a generic summary that is posted for all ROSES elements. For specific information on this particular program element download and read the PDF of the text of this program element by going to Tables 2 or 3 of this NRA at http://solicitation.nasaprs.com/ROSES2024table2 and http://solicitation.nasaprs.com/ROSES2024table3, respectively, click the title of the program element of interest, a hypertext link will take you to a page for that particular program element. On that page, on the right side under "Announcement Documents" the link on the bottom will be to the PDF of the text of the call for proposals. For example, if one were interested in The Lunar Data Analysis Program (NNH24ZDA001N-LDAP) one would follow the link to the NSPIRES page for that program element and then to read the text of the call one would click on C.8 Lunar Data Analysis Program (.pdf) to download the text of the call. If one wanted to set it into the context of the goals, objectives and know the default rules for all elements within Appendix C, the planetary science division, one might download and read C.1 Planetary Science Research Program Overview (.pdf) from that same page. While the letters and numbers are different for each element within ROSES (A.12, B.7, etc.) the basic configuration is always the same, e.g., the letter indicates the Science Division (A is Earth Science, B is Heliophysics etc.) and whatever the letter, #1 is always the division overview. Frequently asked questions for ROSES are posted at http://science.nasa.gov/researchers/sara/faqs. Questions concerning general ROSES-2024 policies and procedures may be directed to Max Bernstein, Lead for Research, Science Mission Directorate, at [email protected], but technical questions concerning specific program elements should be directed to the point(s) of contact for that particular element, who may be found either at the end of the individual program element in the summary table of key information or on the web list of topics and points of contact at: http://science.nasa.gov/researchers/sara/program-officers-list. Not all program elements are known at the time of the release of ROSES. To be informed of new program elements or amendments to this NRA, proposers may subscribe to: (1) The SMD mailing lists (by logging in at http://nspires.nasaprs.com and checking the appropriate boxes under "Account Management" and "Email Subscriptions"), (2) The ROSES-2024 blog feed for amendments, clarifications, and corrections to at https://science.nasa.gov/researchers/solicitations/roses-2024/, and (3) The ROSES-2024 due date Google calendars (one for each science division). Instructions are at https://science.nasa.gov/researchers/sara/library-and-useful-links (link from the words due date calendar).

This funding opportunity supports institutions and individuals in developing innovative programs and tools to promote research integrity and prevent misconduct in biomedical and behavioral research.

This program provides funding for innovative partnerships that help reduce poverty through economic growth in developing countries, focusing on initiatives like infrastructure resilience and women's entrepreneurship.

This grant provides financial support to early-stage cancer researchers transitioning to independent faculty positions, helping them develop their research skills and generate preliminary data for future funding applications.

This funding opportunity is designed to strengthen Ukraine's ability to control the transfer of sensitive technologies, targeting not-for-profit organizations, educational institutions, and other entities that can enhance regulatory frameworks and industry awareness in the context of defense technology.

The U.S. Department of State, Bureau of Democracy, Human Rights, and Labor (DRL) announces an open competition for organizations interested in submitting applications for projects that increase transparency in citizens’ rights to due process. Uzbekistan’s constitution and law prohibit arbitrary arrest and detention and provide for the right of any person to challenge the lawfulness of his or her arrest or detention in court. Additionally, by law a judge must review any decision to arrest accused individuals or suspects. Judges grant arrest warrants in most cases. Detention without formal charges is limited to 48 hours, although a prosecutors may request that a judge extend detention an additional 48 hours, after which the person must be charged or released. Judges typically grant such requests, and the judge who issues such an extension is often the same one who presided over the trial, which creates incentives to cover up violations. The arresting authority is required to notify a relative of a detainee of the detention and to question the detainee within 24 hours of arrest. Visibility into arrest procedures and treatment of detainees is low, even for family members of detainees and Uzbekistani civil society engaged on the issue of due process. 2 Through this award, DRL aims to support the safe, secure, and professional collection of credible information on political detainees by Uzbekistani media, Civil Society Organizations, (CSOs) and human rights defenders, for human rights reporting and advocacy and to improve the capacity of Uzbekistani CSOs to advocate for transparency and improved conditions in detention facilities.