Grants for For profit organizations other than small businesses - Federal

The DoD Kidney Cancer, Idea Development Award is a funding opportunity aimed at supporting innovative, high-impact kidney cancer research projects, with a focus on scientific rationale, preliminary data, innovation, and potential impact, and encourages collaborations among academia, industry, military services, and other federal agencies, with a budget not exceeding $800,000 for individual projects and $1.2M for partnered projects.

A. PROGRAM DESCRIPTION U.S. Embassy Maseru announces an open competition for organizations and individuals interested in submitting applications to implement a project that will deliver tailored human rights training modules for Lesotho Correctional Services (LCS) leadership and policymakers, covering topics such as international human rights standards, inmate rights, ethical conduct, and conflict resolution. This training should include interactive workshops and scenario-based learning exercises. Additionally, the project will support the establishment of a dedicated human rights unit within LCS to oversee compliance and investigate reported abuses.Program Objectives:1. Conduct comprehensive human rights training for Lesotho law enforcement agencies, and specifically LCS, building on previous UNDP training, to enhance their understanding and application of human rights principles in daily operations.2. Support the creation of a dedicated human rights unit within LCS. Establish criteria the new unit can use to monitor and report human rights violations, oversee compliance with human rights standards and investigate reported abuses effectively to ensure accountability and transparency.Anticipated Outcome(s):1. Increased awareness, knowledge, and understanding of international human rights principles and ethical conduct among LCS officials will allowfor an environment where preventative measures can be implemented to forestall human rights violations.2. Improved ability to handle conflict resolution and protect inmate rights.3. Improved reporting and accountability mechanisms for addressing human rights violations within LCS.4. Improved oversight of human rights compliance within the LCS.5. Reduced incidents of human rights abuses and enhanced respect for inmate rights within correctional facilities.Participants and Audiences: All applicants must be registered Civil Society Organizations, Non-Governmental Organizations, or individuals with demonstrated experience in human rights training and capacity-building.Any application that is received after the deadline, is incomplete, or is missing required documentation will be rejected.Please Note: The U.S Embassy Maseru retains the right to ask for additional documents not included in this NOFO.Application guidelines can be requested via email, [email protected] U.S. Embassy Maseru will accept applications from July 16, 2024 to August 16, 2024

The FY24 PCRP Data Science Award mechanism supports research where quantitative and analytical approaches, processes, and/or systems are developed and/or used to obtain knowledge and insight from large and/or complex sets of prostate cancer data. If successful, the studies will enable progress toward addressing one or more of the FY24 PCRP Overarching Challenges. It is expected that any resources, tools, or computational processes generated by this award will be openly shared with the prostate cancer research and patient community. This mechanism is intended to fund research built upon the logic, concepts, and methods of one or more of the following research areas as they pertain to prostate cancer: Computational biology Bioinformatics Artificial intelligence and machine learning Epidemiology Analysis of omics data Medical imaging Digital pathology Analysis of other clinically annotated datasetsApplications may combine diverse data types for integrative analysis to increase knowledge about prostate cancer with respect to the FY24 PCRP Overarching Challenges. Applications that propose to develop resources or tools that allow research, clinical care, and patient community access to standardized and harmonized datasets for real-time clinical care applications are of particular interest; however, this award must not be used to support the development of new datasets. Studies utilizing data derived from large patient studies that include long-term health records or repositories with well-annotated and high-quality biospecimens are encouraged.Key Features: Research Approach: Applications may propose development of a new data-science-driven tool or apply an existing tool or method to gather and analyze information from large datasets with the intent of advancing prostate cancer research and patient care relative to the FY24 PCRP Overarching Challenges. Inclusion of preliminary data to support the scientific rationale and feasibility of research approaches is strongly encouraged, but not required. Any preliminary data provided should be from the laboratory of the Principal Investigator(s) (PI[s]) or member(s) of the collaborating team. Applicants are encouraged to include plans for rigorous validation, benchmarking, comparisons, and/or evaluations to assess the quality or utility of the tools and/or approaches that will be used or developed under this award. Any datasets used in the study design must be from established, retrospective databases and be sufficient in size to provide appropriate analytical and statistical power. Prospective recruitment of human subjects and/or clinical trials is not allowed under this funding opportunity. Applicants are expected to provide documentation demonstrating access to the appropriate datasets and/or patient samples in numbers sufficient to achieve robust results. Impact: Applications are required to clearly communicate how the proposed quantitative and/or analytical approaches, processes, and/or systems will address and provide a solution to one or more of the FY24 PCRP Overarching Challenges. The potential impact of the research, both short- and long-term, should be clearly described, including how the anticipated outcomes or products are distinct from existing research efforts in this area and/or how they will significantly outperform current approaches in this area. High-impact research will, if successful, significantly advance prostate cancer research and/or patient care. Data and Resource Sharing Plan: It is expected that any resources, tools, and computational processes that are developed under this award will be openly shared with the prostate cancer research and patient community. Plans must be provided for how additional data generated by future studies will be incorporated to further inform and refine the data science tools, processes, and/or methods generated and/or used in this study. Refer to the CDMRPs Policy on Data Resource Sharing located on the Electronic Biomedical Research Application Portal (eBRAP) Funding Opportunities Forms web page https://ebrap.org/eBRAP/public/Program.htm for more information about the CDMRPs expectations for making data and research resources publicly available.Partnering PI Option: The FY24 PCRP Data Science Award encourages applications that include meaningful and productive collaborations between investigators. The PIs may have expertise in similar or disparate scientific disciplines, but each PI is expected to bring distinct contributions to the application; collaborations between data scientists and clinicians are highly encouraged. The Partnering PI Option is structured to accommodate two PIs. One PI will be identified as the Initiating PI and will be responsible for the majority of the administrative tasks associated with application submission. The other PI will be identified as a Partnering PI. Both PIs should contribute significantly to the development and execution of the proposed research project, including the Project Narrative, Statement of Work (SOW) and other required components. If recommended for funding, each PI will be named on separate awards to the recipient organization. Each award will be subject to separate reporting, regulatory, and administrative requirements. For individual submission requirements for the Initiating and Partnering PI, refer to Section II.D.2, Content and Form of the Application Submission.A congressionally mandated Metastatic Cancer Task Force was formed with the purpose of identifying ways to help accelerate clinical and translational research aimed at extending the lives of advanced state and recurrent patients. As a member of the Metastatic Cancer Task Force, the CDMRP encourages applicants to review the recommendations (https://health.mil/Reference-Center/Congressional-Testimonies/2018/05/03/Metastatic-Cancer-Research) and submit research ideas to address these recommendations provided they are within the limitations of this funding opportunity and fit within the FY24 PCRP priorities.Innovative research involving nuclear medicine and related techniques to support early diagnosis, more-effective treatment, and improved health outcomes of active-duty Service Members and their Families is encouraged. Such research could improve diagnostic and targeted treatment capabilities through noninvasive techniques and may drive the development of precision imaging and advanced targeted therapies.Applications from investigators within the military services and applications involving multidisciplinary collaborations among academia, industry, the military services, the U.S. Department of Veterans Affairs (VA), and other federal government agencies are highly encouraged. These relationships can leverage knowledge, infrastructure, and access to unique clinical populations that the collaborators bring to the research effort, ultimately advancing research that is of significance to Service Members, Veterans, and/or their Families. If the proposed research relies on access to unique resources or databases, the application must describe the access at the time of submission and include a plan for maintaining access as needed throughout the proposed research.All projects should adhere to a core set of standards for rigorous study design and reporting to maximize the reproducibility and translational potential of clinical and preclinical research. The standards are described in SC Landis et al., 2012, A call for transparent reporting to optimize the predictive value of preclinical research, Nature 490:187-191 (http://www.nature.com/ nature/journal/v490/n7419/full/nature11556.html). While these standards are written for preclinical studies, the basic principles of randomization, blinding, sample-size estimation, and data handling derive from well-established best practices in clinical studies.Clinical trials are not allowed. A clinical trial is defined in the Code of Federal Regulations, Title 45, Part 46.102 (45 CFR 46.102) as a research study in which one or more human subjects are prospectively assigned to one or more interventions (which may include a placebo or another control) to evaluate the effects of the interventions on biomedical or behavioral health-related outcomes.Studies that do not seek to measure safety, effectiveness, and/or efficacy outcome(s) of an intervention are not considered clinical trials.For the purposes of this funding opportunity, research that meets the definition of a clinical trial is distinct from clinical research. Clinical research encompasses research with human data, human specimens, and/or interaction with human subjects. Clinical research is observational in nature and includes:(1) Research conducted with human subjects and/or material of human origin such as data, specimens, and cognitive phenomena for which an investigator (or co-investigator) does not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention. Research meeting this definition may include but is not limited to: (a) mechanisms of human disease, (b) diagnostic or detection studies (e.g., biomarker or imaging), (c) health disparity studies, and (d) development of new technologies.(2) Epidemiologic and behavioral studies that do not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention.(3) Outcomes research and health services research that do not fit under the definition of clinical trial.Excluded from the definition of clinical research are in vitro studies that utilize human data or specimens that cannot be linked to a living individual and meet the requirements for exemption under 46.104(d)(4) of the Common Rule.The funding instrument for awards made under the program announcement will be grants (31 USC 6304).The anticipated direct costs budgeted for the entire period of performance for an FY24 PCRP Data Science Award should not exceed $1.0M. Refer to Section II.D.5, Funding Restrictions, for detailed funding information.Awards supported with FY24 funds will be made no later than September 30, 2025.The CDMRP expects to allot approximately $11.2M to fund approximately seven Data Science Award applications. Funding of applications received is contingent upon the availability of federal funds for this program, the number of applications received, the quality and merit of the applications as evaluated by peer and programmatic review, and the requirements of the government. Funds to be obligated on any award resulting from this funding opportunity will be available for use for a limited time period based on the fiscal year of the funds. It is anticipated that awards made from this FY24 funding opportunity will be funded with FY24 funds, which will expire for use on September 30, 2030.

This funding opportunity seeks to partner with a variety of organizations to enhance justice, protect human rights, and promote security initiatives globally.

This funding opportunity provides financial support to organizations that mentor at-risk youth, helping them reduce delinquency and improve their life outcomes through training, resources, and technical assistance.

The U.S. Department of State, Bureau of Democracy, Human Rights and Labor announces an open competition for organizations interested in submitting applications for a project to address the ethnic marginalization across Coastal West Africa. The U.S. Department of State, Bureau of Democracy, Human Rights and Labor (DRL) announces an open competition for organizations interested in submitting applications for a project to address the ethnic marginalization across Coastal West Africa. The consolidation of power, poor governance, and rise of violent extremism in some Coastal West African countries have contributed to the exclusion and discrimination of certain ethnic groups in politics and everyday life. While certain ethnic groups are not legally excluded from civic and political participation, their full engagement in decision-making roles remains limited. Certain ethnic groups are particularly marginalized in the government, the civil service, and the armed forces. Some ethnic groups also experience discrimination in employment and access to credit, health care, and education. Hundreds of thousands of individuals, including migrants and rural-based members of society, lack documentation to obtain citizenship or access public resources despite protections under the law. In addition, certain ethnic groups face societal discrimination, including stigmatization, harassment, and attacks. Militant groups have exploited the marginalization of certain ethnic groups by playing on grievances and amplifying 2 feelings of distrust in government to recruit members. For example, the targeting of Fulbe communities—based on the belief that they all support jihadi insurgents—has perpetuated conflict, facilitated jihadi recruitment, and risks spreading the violence into new areas. The property and land rights systems across Coastal West Africa has disenfranchised certain ethnic groups historically, causing violence to erupt at times. For example, pastoralist communities who have lived in certain areas for decades have faced the encroachment of agriculturalists on land that they typically use for grazing. In addition, governments across the region have introduced new laws and policies that limit pastoralists’ way of life. Further problematic is that the agencies in charge of developing new land rights policies and programs do not include members of the ethnic groups that would be heavily impacted by the changes. To respond to these challenges, DRL is seeking proposals with the goal of supporting members of marginalized communities in Coastal West Africa—specifically Ghana, Cote d’Ivoire, Benin, and /or Togo—to improve respect for their political rights and civil liberties. Proposals may focus on individual countries or multiple countries, but approaches must be led by, or have strong support from and participation by, groups and individuals representing marginalized ethnic groups. Proposals may include but do not need to support members of pastoralist communities. DRL recognizes that there are numerous other ethnic groups in the region that do not fully enjoy the rights enumerated by law. Applicants are encouraged to complement and deconflict with existing programs that address ethnic marginalization in the region. DRL seeks proposals for programming that are ambitious but also targeted and achievable. DRL will consider proposals that address the goal reflected above but include different, though similar and related, objectives. While proposals may include additional objectives, inclusion of additional objectives will not make a proposal more competitive.

This funding opportunity is designed to improve access to quality health services for women and children in five provinces of Afghanistan, focusing on critical health issues such as maternal and newborn health, family planning, and nutrition.

The U.S. Department of State, Bureau of Democracy, Human Rights, and Labor (DRL) announces an open competition for organizations interested in submitting applications for projects that increase protections against gender-based violence (GBV) and other types of hate-based crimes in Bulgaria, Czechia, Romania, and Slovakia, including against marginalized communities.

The U.S. Department of State, Bureau of Democracy, Human Rights, and Labor (DRL) announces an open competition for organizations interested in submitting applications for projects that support the sustainability of independent media in Ukraine.

Amendment 1 (June 25, 2024): The purpose of this Amendment 1 is to: 1) make administrative updates to Section 1.1, 1.2, 2.1.2, 3.1, 3.2 and 5.2.6; 2) replace Section 2.1.1 with new language pertaining to Federally Funded Research and Development Centers (FFRDCs) and Government Entities. Additionally, Section 4.2, Evaluation Criteria #2 is updated to remove the reference to Government Entities (removal is not highlighted in yellow); 3) change references from Abstract to Solution Summaries (intent behind the document is unchanged); 4) update proposal submission instructions in Section 3.2; and 5) update Section 5.1 to remove the Stage 2 Notification Letter. All changes are highlighted in yellow.Also, please note that the title of this opportunity has bee revised to eliminate confusion. The opportunity should have been titled, "Master Announcement Instruction (MAI)" instead of "ARPA-H BDF Tool Box".The Master Announcement Instructions (MAI) is a new ARPA-H announcement that aims to create standard tiered proposal submission requirements, so the amount of work required to write a proposal is commensurate with the size of the proposed effort. It also aims to reduce the up-front work required to submit cost information to reduce the barrier to entry for non-traditional performers. Module announcements that link to this MAI will provide more specific instructions about how the proposal requirements vary across tiers of effort.All responsible sources capable of satisfying the Governments needs may submit a proposal to a Module Announcement. Specifically, universities, non-profit organizations, small businesses and other than small businesses are eligible and encouraged to propose to Module Announcements.NOTE: Proposals shall NOT be submitted against the MAI. Proposals shall only be submitted against a Module Announcement.

This funding opportunity provides financial support to a wide range of organizations for improving public health surveillance and treatment practices for inherited bleeding disorders, ultimately aiming to enhance health outcomes for affected individuals.

The purpose of the Delta Health Systems Implementation Program (DSIP) is to improve healthcare delivery in rural areas by implementing projects that will improve the financial sustainability of hospitals and allow for increased access to care in rural communities. These projects focus on financial and operational improvement, quality improvement, telehealth, and workforce development in hospitals in the in the rural counties and parishes of the Delta region. This program supports HRSA's collaboration with the Delta Regional Authority.

The DoD Reconstructive Transplant, Qualitative Research Validation and Implementation Award aims to fund further research and development of resources for the Vascularized Composite Allograft (VCA) community, which were initially created through RTRP-funded qualitative research studies, to enhance their readiness for clinical and community use, with a focus on improving patient outcomes and benefiting population health.

The U.S. Department of State announces an open competition for organizations to submit applications to facilitate the launch of the Marine and Blue Economy Hackathon. Please follow all instructions in the "Marine and Blue Economy Hackathon NOFO Full Instructions" document under the Related Documents tab. Priority Region: Lagos, Nigeria Overview and Purpose Inadequate technological solutions and lack of coordination across Nigerias marine and blue economy-related sectors have led to untapped economic opportunities, unsustainable fishing practices, plastic pollution, and environmental damage. To implement the Partnership for Atlantic Cooperation Plan of Action and to bolster U.S.-Nigeria relations, a selected implementing partner, in consultation with the U.S. Mission Nigeria, will launch the Marine and Blue Economy Hackathon. This two- to three-day event will bring together approximately 60 working-level government officials, private sector experts, academics, entrepreneurs, and students to crowdsource innovative technical solutions to marine and blue economy-related problems. Defining Problem Statements, Crowdsourcing Solutions, and Measuring Results The selected implementing partner, in consultation with the U.S. Mission in Nigeria, will define three marine and blue economy-focused problem statements. Problem statements should reflect local needs and the priorities established by the Partnership for Atlantic Cooperation member countries including sustainable fisheries management, plastic pollution prevention, coastal community resilience, marine conservation, sustainable aquaculture management, ghost gear solutions, aquatic food technology advancement, ocean data and information gathering and analysis, and marine spatial planning implementation. During the hackathon, participants will: (a) translate multifaceted problems into succinct technical specifications and statements recognizable to software and technology designers; and (b) form teams to generate actionable and innovative technical solutions to the shared problem statement(s). At the end of the hackathon, a winner will be selected by a board of American and Nigerian judges for the most innovative and impactful solution developed, and a prize will be offered. After the hackathon, participants will then deploy the solutions they collaboratively design, leverage partnerships established with their counterparts across the sector, and closely coordinate with one another to ensure the solutions address the identified problems. Hackathon results can be measured by number and quality of targeted small-group sessions, the introduction of new tools and technologies, and creation of prototypes that address the problems hackathon participants tackle. In order to be considered, implementing partner applicants must demonstrate a clear commitment to inclusive participation. The selected implementing partner must reach out to potential participants from marginalized populations and communities, ensure balance among hackathon participants, and provide accessibility accommodations as needed. Participants and Audiences This two- to three-day event will bring together approximately 60 working-level government officials, private sector experts, academics, entrepreneurs, and students to crowdsource innovative technical solutions to marine and blue economy-related problems.

With this solicitation, BJA seeks to support the families of fallen and catastrophically injured law enforcement officers, firefighters, and other first responders by providing assistance with filing applications for federal benefits for line-of-duty deaths and catastrophic injuries. This program also provides survivor peer support, counseling services, and resources to survivors of fallen law enforcement officers, firefighters, and other first responders nationwide. Additionally, the program recognizes families and fallen officers at memorial events.

The intent of the FY24 LCRP Concept Award is to support innovative, non-incremental, high-risk/potentially high-reward research that will provide new insights, paradigms, technologies, or applications in lung cancer. Studies supported by this award are expected to lay the groundwork for future avenues of scientific investigation. The proposed research project should include a well-formulated, testable hypothesis based on a sound scientific rationale and study design. Research applications only in the area of mesothelioma will not be accepted.Inclusion of preliminary data is not required but is allowed. The strength of the proposed research should be based on sound scientific rationale and logical reasoning. The presentation of substantial preliminary data suggests that the proposed research project would be more appropriately submitted to a different FY24 LCRP funding opportunity. The outcome of research supported by this award should be the generation of robust preliminary data that can be used as a foundation for future research projects. Absence of preliminary data will not negatively affect scientific or programmatic review of the application.Care Delivery and Health Disparity Option: The FY24 LCRP Concept Award mechanism encourages applications that specifically address the comprehensive lung cancer care and/or health disparities FY24 LCRP Areas of Emphasis by offering a Care Delivery and Health Disparity option. Applications from the Care Delivery and Health Disparity option will be peer and programmatically reviewed separately from applications submitted to the Cancer Research Continuum option.Relevance to Military Health: The LCRP seeks to support research that is relevant to the healthcare needs of military Service Members, Veterans, and their Families. Relevance to military health will be considered in determining relevance to the mission of the Defense Health Program (DHP) and FY24 LCRP during programmatic review. Investigators are strongly encouraged to consider the following characteristics as examples of how a project may demonstrate relevance to military health:Use of military or Veteran populations, biospecimens, data/databases, or programs in the proposed research Collaboration with Department of Defense (DOD) or Department of Veterans Affairs (VA) investigatorsExplanation of how the project addresses an aspect of lung cancer that has relevance or is unique to the military, Veterans, other Military Health System (MHS) beneficiaries, or Family readiness of Service Members, including environmental exposures other than tobacco.All investigators applying to FY24 LCRP funding opportunities are encouraged to consider leveraging resources from the LCRP-funded Lung Cancer Biospecimen Resource Network (LCBRN) if retrospectively collected human anatomical substances and correlated clinical data are relevant to the proposed studies. Samples from the LCBRN are currently available through the Cooperative Human Tissue Network (CHTN). To request LCBRN samples, contact the Division Coordinator for the CHTN Mid-Atlantic division (email: [email protected]) located at the University of Virginia.A congressionally mandated Metastatic Cancer Task Force was formed with the purpose of identifying ways to help accelerate clinical and translational research aimed at extending the lives of advanced state and recurrent patients. As a member of the Metastatic Cancer Task Force, the CDMRP encourages applicants to review the recommendations (https://health.mil/Reference-Center/Congressional-Testimonies/2018/05/03/Metastatic-Cancer-Research) and submit research ideas to address these recommendations provided they are within the limitations of this funding opportunity and fit within the FY24 LCRP priorities.Applications from investigators within the military services and applications involving multidisciplinary collaborations among academia, industry, the military services, the VA, and other federal government agencies are highly encouraged. These relationships can leverage knowledge, infrastructure, and access to unique clinical populations that the collaborators bring to the research effort, ultimately advancing research that is of significance to Service Members, Veterans, and/or their Families. If the proposed research relies on access to unique resources or databases, the application must describe the access at the time of submission and include a plan for maintaining access as needed throughout the proposed research.

The FY24 ARP Idea Development Award supports the development of innovative, high-risk/high-reward research that could lead to critical discoveries or major advancements that will accelerate progress in improving outcomes for Autistic individuals. Applications are strongly encouraged to address one of the FY24 ARP Idea Development Award Areas of Interest or provide justification that the proposed research addresses a critical problem, question, or need in ASD. This award mechanism is designed to support innovative ideas with the potential to yield impactful data and new avenues of investigation.Research funded by the FY24 ARP should be responsive to the needs of people with ASD, their families, and/or caregivers. Researchers are therefore encouraged to establish and utilize effective collaborations and partnerships with community members to maximize the translational and impact potential of the proposed research.CDMRP encourages research on health areas and conditions that affect women uniquely, disproportionately, or differently from men, including studies analyzing sex as a biological variable. Such research should relate anticipated project findings to improvements in womens health outcomes and/or advancing knowledge for womens health.

The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The overarching goal of this NHGRI R25 program is to support educational activities that encourage undergraduates from diverse backgrounds, including those from groups underrepresented in the biomedical workforce, to pursue further training and careers in the scientific, medical, ethical, social and/or legal areas of genomics research. To accomplish the stated over-arching goal, this FOA will support creative educational activities with a primary focus on: Research Experiences Courses for Skills Development This Genome Research Experiences to Attract Talented Undergraduates into the Genomic Field to Promote Diversity (GREAT) Program will support collaborative institutional partnerships that provide research education programs for undergraduates enrolled at minority-serving institutions (MSIs) or Institutional Development Award (IDeA)-eligible institutions. A partnership will include a MSI or IDeA-eligible institution, and one or more research-intensive institutions or organizations with a suitable research base for graduate-level training in scientific areas of interest to NHGRI.

This funding opportunity is designed to enhance health services by engaging the private sector to improve family planning, maternal and child health, and control infectious diseases in various communities.

This grant provides funding to small businesses and startups that have previously received NSF Phase I awards, helping them advance their innovative research into market-ready products and services.