Grants for For profit organizations other than small businesses - Federal

The U.S. Embassy Dushanbe, Tajikistan announces an open competition opportunity to implement the English Without Borders (EWB) project in Tajikistan. The EWB project has a number of components and objectives highlighted in this funding opportunity to support English teachers through (1) providing professional development and peer- to- peer engagement and networking; (2) equipping secondary school teachers with modern teaching methodologies, and (3) utilizing the newly designed and published English textbooks. The implementer must be a legally recognized non-governmental organization, that meets U.S. and Tajikistan technical and legal requirements to develop and implement Public Diplomacy Programs as specified in Section C. Background: English Without Borders (EWB) is a project funded by the U.S. Embassy in Tajikistan and implemented since 2021, providing support to English teachers across all regions in Tajikistan. The current EWB project will conclude December 2024; this year PDS seeks to consolidate some English Language Programs under one umbrellanamely continuing EWB networking-type activities, but also providing more targeted support for secondary school (high school) English teachers to use modern teaching methods as well as the new English language textbook. EWB unites English language teachers and students at all levels, supporting them through peer-to-peer networking, the development of pedagogical materials, online and in-person training sessions, and train-the-trainer programs. These online and in-person activities develop teachers capacity to employ modern, student-centric methodologies and design supplementary materials. The U.S. Embassy in Dushanbe has an ambitious slate of English language projects, many in cooperation with the Ministry of Education and Science. These efforts support Tajikistans strategy on improving English language learning by 2030 and President Rahmons 2024 statement on learning foreign languages, including English. While the number of students interested in learning English is on the rise, the number of teachers qualified and prepared to teach them is not. This is due to the relatively sudden increase in the number of classes offered, the relatively recent emergence of English as a foreign language -- resulting in few professional teachers with a specialization in English -- and an insufficient number of English teachers. U.S. Embassy English language programs range from secondary school teacher training programs and providing English language textbooks to English Access Scholarship programs and supporting universities with English Resource Centers and English Language Fellows. In its new iteration, EWB should continue to complement and expand their collaboration with other PDS-funded projects and their participants. Due to the demand for the U.S. Embassy Dushanbes English language programs, the EWB network should continue to utilize its platforms to reach teachers across the country. EWB should continue to expand its partnership with other governmental, non-governmental, private, and international organizations to support a sustainable network for English teachers and students and provide access to learning resources, including collaboration with TESOL International Association, the English-Speaking Nation Project in Uzbekistan, and English Teachers Associations in Dushanbe and across Central Asia. The expected date range for implementation of project is December 1, 2024, to December 1, 2026. Please follow the instructions below for the application. Project Goal: Develop a network of English language educators and educational institutions across Tajikistan to deliver high-quality and effective English language instruction. Project Audience(s): Direct Audience Approximately 4,000 secondary school English teachers of Tajikistan Teachers at higher education institutions teaching in English (English language and other subjects) Tajikistan English Teachers Association members USG English-language program alumni (Fulbright TEA, FLTA, ETM, OPEN online course, SUSI, Access Scholarship programs) Institute of Professional Development members EWB members Project Objectives: Objectives: Objective 1: Increase participation of English language educators from educational institutions, particularly secondary schools, in rural areas of the DRS, Gorno-Badakhshan, Khatlon, and Sughd regions by 10% each year. Objective 2: Increase the ability of secondary school teachers from rural areas (DRS, Gorno Badakhshan, Khatlon, Sughd regions) to use modern teaching methods with the new English language textbook through comprehensive training conducted by EWB regional trainers and mini grants. Objective 3: Increase the number of EWB initiatives implemented at schools, universities and institutions, and local communities in urban and rural areas through .... Objective 4: Increase knowledge sharing between USG English language program alumni and non-alumni English language educators through mentorship programs. Objective 5: Strengthen collaboration and knowledge sharing practices between English teacher associations and English teacher networks in Central Asian countries, including Tajikistan, Kyrgyz Republic, Kazakhstan, Uzbekistan and Turkmenistan. Objective 6: Identify avenues for collaboration with the Ministry of Education and Sciences Institute of Professional Development (IPD), such as joint research, curriculum, or teacher training programs. Activities: Hold an annual leadership development program to support proactive English teachers in the regions to take on new initiatives and cooperate with the EWB regional representatives in promoting EWB activities at schools and in local communities. Create a team of EWB leaders/ambassadors in each of the four regions to hold weekly professional development and capacity building events and organize annual regional meetings. Strengthen the community of USG English language alumni in the regions (Fulbright TEA, FLTA, ETM, OPEN online course, SUSI, FLEX, Access Scholarship programs) and develop mentorship programs in each region to engage the alumni in different EWB activities and events, and to act as mentors to other (non-alumni) English teachers. Sustain dynamic work and explore new avenues for collaboration with the Institute of Professional Development (IPD) under the Ministry of Education and Science. Strengthen and expand upon our partnership with English teacher associations and English teachers networks in Central Asian countries through national and international online collaborative events and activities. Train teachers to use the new English language textbooks, for example through the EWB regional trainers activities and EWB mini grant.

The "Genetic Architecture of Mental Disorders in Ancestrally Diverse Populations II" grant aims to expand the existing mental health research network to include larger studies, provide guidance to the scientific community, and support career development for researchers from low-resource settings worldwide.

This funding opportunity supports educational programs that engage middle and high school students, as well as undergraduates from diverse and underrepresented backgrounds, in cancer research to inspire future careers in biomedical sciences.

This Notice of Funding Opportunity (NOFO) is the second issued under the Public Wireless Supply Chain Innovation Fund (Innovation Fund). The Innovation Fund is an NTIA-administered competitive grant program that seeks to accelerate the development, deployment, and adoption of open and interoperable radio access networks (RAN). In this second NOFO, NTIA aims to advance open radio unit (RU) commercialization and innovation by funding activities that 1) accelerate the development of open RU products to the point where they meet carrier needs and are ready for commercial trials, and 2) improve the overall performance and capabilities of open RUs through targeted research and development. The RU is the largest part of the carrier network and an easy entry point to the network, offering a low-risk deployment option to Mobile Network Operators (MNOs) interested in Open RAN. Investing in the commercialization and innovation of these components in the Innovation Funds second funding opportunity can spur MNO adoption of open RUs during upcoming equipment buying cycles, generating momentum toward greater MNO adoption of the broader suite of open and interoperable RAN components. The transition to open and interoperable wireless networks becomes a more feasible and attractive proposition in the wireless market when there is broad deployment of open RUs that meet or exceed MNO requirements, and components are available from suppliers at scale.

This announcement is designed to accompany PRMs General NGO Guidelines, which contain additional information on PRMs priorities and NGO funding strategy with which selected organizations must comply, unless otherwise specified in this notice of funding opportunity. Please use both the General NGO Guidelines and this announcement to ensure that your submission is in full compliance with PRM requirements and that the proposed activities are in line with PRMs priorities. Submissions that do not reflect the requirements outlined in these guidelines will not be considered. Where there is differing guidance, instructions in this NOFO announcement supersede any divergent guidance in the NGO Guidelines. The Bureau of Population, Refugees, and Migration is seeking proposals from organizations from North, Central and South America as well as the Caribbean to create a technical secretariat to support the implementation of the Los Angeles Declaration on Migration and Protection, a hemispheric international forum that promotes safe, orderly, and humane migration and access to protection in the Western Hemisphere. Implementation includes supporting meetings of the Declaration and working groups (known as Action Package Committees), tracking work completed on governments commitments, advancing work with key stakeholders, and other work as defined below.

The U.S. Embassy to Angola and Sao Tome e Principe in Luanda is pleased to announce the availability of an open competition funding opportunity to carry out a project to empower lawyers, legal professionals, and human rights defenders to advocate for access to justice for vulnerable populations and provide adequate defense in cases of human rights violations, particularly in cases related to freedom of speech and assembly and arbitrary detention of human rights defenders. The project aims to create a unified vision for the legal defense of human rights in Angola. While the law states that all detainees have a right to legal counsel, either chosen by them or appointed by the government on a pro bono basis, legal professionals report that there are an insufficient number of lawyers to handle the volume of criminal cases. This situation is exacerbated for vulnerable populations (women, youth, underrepresented ethnic groups), detainees outside of Luanda, and cases involving sensitive human rights issues. This project should complement and build upon prior and ongoing work in these areas by international organizations, or non-governmental organizations (NGOs), but ideally would seek to meet challenges not currently being addressed by other projects.

NISTs Standards Coordination Office is seeking applications from eligible applicants for activities to establish and maintain a Standardization Center of Excellence (SCoE) to support U.S. engagement in international standardization for critical and emerging technologies (CETs) that are essential to U.S. economic competitiveness and national security. The scope of this institutional award, as described in the Department of Commerce Grants and Cooperative Agreements Manual, Chapter 6.A.2 (20 April 2021), encompasses all critical areas of standardization such as pre-standardization engagement, measurement standards, reference standards, documentary standards, conformity assessment, and management systems.

The Federal Transit Administration (FTA) announces the opportunity to apply for a total of $1,936,000 in Fiscal Year (FY) 2023 Public Transportation Innovation funds in competitive cooperative agreement awards for projects that enhance mobility innovations for transit. Funds will be awarded for projects that advance emerging technologies, strategies, and innovations in traveler-centered mobility in two distinct areas. Of the total available funds, $968,000 is available for projects to accelerate innovations that improve mobility and enhance the rider experience with a focus on innovative service delivery models, creative financing, novel partnerships, and integrated payment solutions. Another $968,000 is available for projects to develop software solutions that facilitate the provision of integrated demand-response public transportation service that dispatches public transportation fleet vehicles through riders mobile devices or other means.

This notice announces the opportunity to apply for funding under the Technology-enabled Collaborative Learning Program (TCLP). The purpose of this program is to improve retention of health care providers and increase access to health care services, such as those to address chronic diseases and conditions (including Alzheimers disease), infectious diseases, mental health and substance use disorders, prenatal and maternal health, pediatric care, pain management, palliative care, and other specialty care in rural areas, frontier areas, health professional shortage areas, or medically underserved areas and for medically underserved populations or Native Americans. Recipients will evaluate, develop, and, as appropriate, expand the use of technology-enabled collaborative learning and capacity building models. In this NOFO, the term "technology-enabled collaborative learning and capacity building model" means a distance health education model that connects health care professionals, and particularly specialists, with multiple other health care professionals through simultaneous interactive videoconferencing for the purpose of facilitating case-based learning, disseminating best practices, and evaluating outcomes. This cooperative agreement aligns with HRSAs goals of promoting a health care workforce to address current and emerging needs, improving access to quality health services, achieving health equity, and enhancing population health. The development and acquisition of instructional programming by the TCLP will increase access to quality care using telehealth and innovative technology solutions. The TCLP will also provide training for health care providers and other professionals that provide or assist in the provision of services, including training on best practices for data collection and evaluation activities to study the impact on patient outcomes and health care providers.

USAID/Senegals Sahel Regional Office (USAID/Senegal/SRO) ADDENDUM #1 - CALL FOR CONCEPT PAPERS USAID Strengthening Information Integrity and Resilience (IIR) in the Sahel USAID Sahel Information Integrity Annual Program Statement No. 72068524APS00003 Issuance Date: June 28, 2024 Closing Date: July 30, 2024 Questions Due Date for this APS Addendum: July 9, 2025 Dear Prospective Applicants: This is an Addendum to the USAID Sahel Information Integrity Annual Program Statement (APS) (No.72068524APS00003). All interested organizations should carefully review both this Addendum AND the full APS, which can be found here in grants.gov . Important information contained in the APS announcement is not necessarily repeated in this specific Addendum. This activity is authorized under the Foreign Assistance Act of 1961, as amended. Through this Addendum #1 to APS No. 72068524APS00003, USAID/Senegal/SRO is requesting the submission of concept papers focused on Strengthening Information Integrity and Resilience (IIR) in the Sahel. Concept papers should describe a nimble and adaptive approach for supporting key actors in local and regional information ecosystems to be more effective in advancing information integrity and resilience in their local and regional systems. TARGET COUNTRIES: All three objectives of this activity (as outlined under technical focus below) must be addressed in all of the following countries, which fall under the management authority of USAID/Senegal/SRO: Burkina Faso Chad Mauritania Objective 2 under this APS (which relates to strengthening regional networks) may also create opportunities for partner organizations in Cabo Verde, The Gambia, Guinea-Bissau, Mali, Niger, and Senegal based on prior approval from USAID. Under this Addendum, subject to the availability of funds, USAID anticipates making one award. USAID also reserves the right to make no awards. The total USAID funds anticipated is $15,000,000. USAID contemplates a start date for the award beginning on or about December 1, 2024, with a period of performance of up to five years. Applicants should send general questions about the below information by email to USAID primary and secondary points of contact, Ms. Aminata Diallo, at [email protected] and Robert Almosd at [email protected], respectively. See " related Documents" Tab for the full Addendum Thank you for your interest in USAID Programs. Sincerely,

The purpose of CIG is to stimulate the development and adoption of innovative conservation approaches and technologies in conjunction with agricultural production in the United States and its territories. CIG projects are expected to lead to the transfer of conservation technologies, management systems, and innovative approaches (such as market-based systems) to agricultural producers, into government technical manuals and guides, or to the private sector. CIG generally funds pilot projects, field demonstrations, and on-farm conservation research. On-farm conservation research is defined as an investigation conducted to answer a specific applied conservation question using a statistically valid design while employing farm-scale equipment on farms, ranches or private forest lands. The CIG program is not a NRCS producer financial assistance program. Project outcomes should benefit a region of a state or the entire state and not just benefit one farm. NRCS will prioritize projects that will implement climate-smart agriculture conservation activities which are targeted to assist agricultural producers and nonindustrial private forestland owners in directly improving soil carbon, reducing nitrogen losses, or reducing, capturing, avoiding, or sequestering carbon dioxide, methane, or nitrous oxide emissions, associated with agricultural production. All CIG projects must involve EQIP-eligible producers that meet EQIPs eligibility requirements listed in 7 CFR 1466.6(b)(1) through (3).

With this solicitation, OJJDP seeks to support a National Community and Schools Youth Drug Prevention Program for the purpose of delivering substance use prevention programs in schools in partnership with local law enforcement and community coalitions. The successful national organization will provide funding and training and technical assistance (TTA) to local non-profits who will be required to build community coalitions in partnership with law enforcement to educate youth in schools and in extracurricular programming on drug prevention. Community coalitions consist of community leaders that organize to meet the local prevention needs of the youth and families in their communities. Partnerships among non-profit organizations, community coalitions and law enforcement ensure that communities implement comprehensive approaches to prevent youth substance use.

The "Facilitating Preclinical and Early Phase Human Studies for New Therapeutics" grant aims to fund research that advances new treatments from preclinical stages to first-in-human trials for aging-related conditions, excluding neurodegenerative and Alzheimer's diseases, with a focus on improving injury repair in older adults and defining clear milestones for progress monitoring.

The DoD Reconstructive Transplant Research Investigator-Initiated Research Award is a funding opportunity aimed at supporting innovative and impactful research projects that contribute to reconstructive transplant science, improve patient care, and enhance the quality of life, with a particular focus on addressing the healthcare needs of military service members, veterans, and their families.

Through this Notice of Funding Opportunity (NOFO), GCJ seeks applications to support accountability processes for alleged atrocity crimes committed globally by members of the Wagner Group and analogous Kremlin-backed paramilitaries, including tracking enablers of these entities, which include corporate actors and financial services firms. Accountability processes can include investigations being pursued by national authorities, including by Ukraines Office of the Prosecutor General (OPG), or other domestic authorities, including where national systems may exercise extraterritorial jurisdiction; cases before international and hybrid courts; efforts to achieve corporate accountability through corporate governance, civil, or administrative proceedings; and proceedings before human rights mechanisms.

This funding opportunity provides up to $1 million to research centers focused on improving the diagnosis, treatment, and prevention of intellectual and developmental disabilities through collaborative and innovative research.

The DoD Reconstructive Transplant, Idea Discovery Award is a funding opportunity aimed at supporting innovative, high-risk/high-reward research projects related to reconstructive transplant, with a focus on generating robust data, addressing military health care needs, advancing women's health research, and adhering to rigorous experimental design, with a total budget not exceeding $500,000.

This grant provides funding for innovative research proposals from universities, non-profits, and businesses to develop disruptive technologies that enhance the U.S. Army's capabilities for future operations.

The "Individually Measured Phenotypes to Advance Computational Translation in Mental Health (IMPACT-MH)" grant aims to support research that develops new behavioral measures and data infrastructure to improve the diagnosis, prognosis, and treatment of mental disorders.

The Academy of Kidney Cancer Investigators (AKCI) is a unique, interactive virtual academy that provides, intensive mentoring, national networking, and a peer group for scientist and clinician junior faculty. The KCRP created the Academy of Kidney Cancer Investigators in FY19 to align with several program priorities, which include to build research capacity in kidney cancer; increase collaborations to advance kidney cancer research, and support innovative research conducted by the next generation of kidney cancer scientists and clinicians. The overarching goal of the AKCI is to increase research capacity in kidney cancer through the development of successful, highly productive kidney cancer researchers in a collaborative research and training environment. The AKCI is a virtual career development and research training platform that currently consists of 11 Early-Career Scholars (ECS)/Designated Mentor pairs from different institutions, and one Academy Director. It is expected that six Early-Career Scholars will graduate by the fall of 2025 and four FY23 AKCI Early-Career Scholars/Designated Mentor awards will be made by September 2024. In addition, Academy graduates will continue to participate in the annual Academy meetings. Information about the Academy is available on the KCRP webpage and in the Kidney Cancer Program Booklet at https://cdmrp.health.mil/kcrp. The AKCI leadership team will identify opportunities for engagement with KCRP AKCI Scholars-Designated Mentors and KCRP FY25 (and subsequent year awardees) Postdoctoral and Clinical Fellowship Awardees. The Academy Director and Deputy Director catalyze the growth and professional development of the Early-Career Scholars in collaboration with their Designated Mentors, assess the progress of the ECSs, and facilitate communication and collaboration among all of the Academy members. The AKCI leadership team will also identify and offer opportunities for engagement (e.g., invitations to seminar series and in-person meetings) with FY24 Postdoctoral and Clinical Fellowship Awardees with FY24 KCRP AKCI-ECS-Designated Mentors (and subsequent year awardees). This FY24 funding opportunity is soliciting applications for an Academy Director (Principal Investigator [PI]) and Deputy Director (Partnering PI) to lead the AKCI. The newly selected FY24 Academy Director and Deputy Director will initiate their responsibilities no later than October 2025. The Academy Director and Deputy Director (hereafter referred to as Academy Leadership) must be established kidney cancer researchers and can be at different institutions. The Academy Leadership must demonstrate a strong record of mentoring and training early career investigators, a commitment to leadership, the ability to articulate methods toward research collaborations, and the ability to objectively assess the progress of all Scholars with their Designated Mentors in the AKCI. Other objectives will include execution of research that will engage AKCI FY24 Scholars (including subsequent-year Scholars), develop tools for Scholars to enable success, and provide opportunities to broaden their knowledge in kidney and renal pelvis cancers. The leadership team will identify and offer occasion(s) for the AKCI to network with KCRP FY24 Postdoctoral and Clinical Fellowship Awardees (and subsequent year awardees). Designated Mentors on FY24 KCRP AKCI Early-Career Scholar Award applications and Designated Mentors on open FY19 through FY23 KCRP AKCI Early-Career Scholar Awards (with the exception of those graduating in 2024) are not eligible to apply for this award. Note: An invited oral presentation is a requirement for application review of the KCRP AKCI LA, as described in Section II.D.2.b.iv, Additional Application Components. Responsibilities of the Academy Leadership include, but are not limited to: Act as a resource for all Scholars and Designated Mentors in the Academy over the Scholars 4-year period of performance. Facilitate communication and collaboration among all Scholars and Designated Mentors (including periodic interactive communication among all Academy members). Develop assessment criteria to evaluate the research progress made by all Scholars, as well as their career progression and sustainment as independent investigators in kidney cancer research. Conduct collaborative kidney cancer pilot project(s) that include Academy Scholars. These pilot projects should have the potential to improve collaboration within the Academy, as well as impact kidney cancer research and/or kidney cancer patients/survivors. o Examples of pilot research projects may include but are not limited to (a) funding an extended statistical or bioinformatics analysis with AKCI Scholars, (b) performing a large-scale meta-analysis of human or animal datasets with AKCI scholars, (c) provide access to critical biorepositories or animal models to expand AKCI investigator analyses or increase study rigor. Provide constructive critiques with the goal of advancing the research and professional careers of the Scholars and strengthening the mentorship of the Designated Mentors. Provide avenues to increase the promotion of the Academy and visibility of Scholars within kidney cancer research and advocacy communities (e.g., peer review, conferences, editorial boards). Support the professional development, to include laboratory management skills, of the Scholars into leading researchers through invited presentations by experts outside of the AKCI LA. Plan and host an annual 1-day workshop and, biennially, a multi-day workshop for all Scholars/Designated Mentor pairs as well as Academy graduates to present their research, share knowledge, and develop collaborative efforts within the AKCI. Scholars will be responsible for their own travel costs to in-person Academy meetings. Include KCRP FY24 Postdoctoral and Clinical Fellowship Awardees in at least one meeting of the FY24 AKCI. These investigators will be responsible for their own travel costs, funds for which are included in their research awards. Establish a panel of patient advocates and Veteran(s) (i.e., the Patient Advocacy Panel) to inform the AKCI on the needs of the patient community. Establish the Designated Mentor Panel to facilitate collaborations among the AKCI participants including the Scholars, Academy Director/Deputy Director, and the Designated Mentors. The Academy of Kidney Cancer Investigators Leadership Award is structured to support two PIs. The Academy Director will be identified as the Initiating PI and will be responsible for the majority of the administrative tasks associated with application submission. The Deputy Director will be identified as the Partnering PI. The collaboration between the Academy Director and the Deputy Director should be supported by complementary expertise and experience. Initiating and Partnering PIs each have different submission requirements, as described in Section II.D.2, Content and Form of the Application Submission; however, both PIs should contribute significantly to the development of the proposed research project. The application should clearly demonstrate that both PIs have equal levels of input on the proposed Academy Leadership and clearly define the components to be addressed by each to support the success of the Scholars. While it is up to the Academy Director and the Deputy Director to define their roles, both Academy Leaders should have interactions with each Scholar-Designated Mentor pair, (and the Scholars Designated Mentors); acting as administrative support does not fulfill the intent of the Director and Deputy Director. If recommended for funding, each PI will be named on separate awards to the recipient organization(s). Each award will be subject to separate reporting, regulatory, and administrative requirements. For individual submission requirements for the Initiating and Partnering PI(s), refer to Section II.D.2, Content and Form of the Application Submission. Organizational-Level Emphasis: The following areas of emphasis are broadly applicable to many CDMRP programs, not just the KCRP. Investigators are encouraged to consider addressing these areas in their applications if doing so is appropriate for their line of research, addresses the FY24 KCRP strategic priorities and/focus areas described in Section II.A.1 and Section II.A.2. Nuclear Medicine: Innovative research involving nuclear medicine and related techniques to support early diagnosis, more effective treatment, and improved health outcomes of active-duty Service Members and their Families is encouraged. Such research could improve diagnostic and targeted treatment capabilities through noninvasive techniques and may drive the development of precision imaging and advanced targeted therapies. Womens Health: CDMRP encourages research on health areas and conditions that affect women uniquely, disproportionately, or differently from men, including studies analyzing sex as a biological variable. Such research should relate anticipated project findings to improvements in womens health outcomes and/or advancing knowledge for womens health. Metastatic Cancer Task Force: A congressionally mandated Metastatic Cancer Task Force was formed with the purpose of identifying ways to help accelerate clinical and translational research aimed at extending the lives of advanced state and recurrent patients. As a member of the Metastatic Cancer Task Force, CDMRP encourages applicants to review the recommendations (https://health.mil/Reference-Center/Congressional-Testimonies/2018/05/03/Metastatic-Cancer-Research) and submit research ideas to address these recommendations provided they are within the limitations of this funding opportunity and fit within the FY24 KCRP priorities. Rigorous Study Design: All projects should adhere to a core set of standards for rigorous study design and reporting to maximize the reproducibility and translational potential of clinical and preclinical research. The standards are described in SC Landis et al., 2012, A call for transparent reporting to optimize the predictive value of preclinical research, Nature 490:187-191 (https://www.nature.com/nature/journal/v490/n7419/full/nature11556.html). While these standards are written for preclinical studies, the basic principles of randomization, blinding, sample-size estimation, and data handling derive from well-established best practices in clinical studies. Military Service Involvement: Applications from investigators within the military services and applications involving multidisciplinary collaborations among academia, industry, the military services, the U.S. Department of Veterans Affairs (VA), and other federal government agencies are highly encouraged. These relationships can leverage knowledge, infrastructure, and access to unique clinical populations that the collaborators bring to the research effort, ultimately advancing research that is of significance to Service Members, Veterans, and/or their Families. If the proposed research relies on access to unique resources or databases, the application must describe the access at the time of submission and include a plan for maintaining access as needed throughout the proposed research. Clinical trials are not allowed under this funding opportunity. A clinical trial is defined in the Code of Federal Regulations, Title 45, Part 46.102 (45 CFR 46.102) as a research study in which one or more human subjects are prospectively assigned to one or more interventions (which may include a placebo or another control) to evaluate the effects of the interventions on biomedical or behavioral health-related outcomes. Studies that do not seek to measure safety, effectiveness, and/or efficacy outcome(s) of an intervention are not considered clinical trials. For the purposes of this funding opportunity, research that meets the definition of a clinical trial is distinct from clinical research. Clinical research encompasses research with human data, human specimens, and/or interaction with human subjects. Clinical research is observational in nature and includes: (1) Research conducted with human subjects and/or material of human origin such as data, specimens, and cognitive phenomena for which an investigator (or co-investigator) does not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention. Research meeting this definition may include but is not limited to: (a) mechanisms of human disease, (b) diagnostic or detection studies (e.g., biomarker or imaging), (c) health disparity studies, and (d) development of new technologies. (2) Epidemiologic and behavioral studies that do not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention. (3) Outcomes research and health services research that do not fit under the definition of clinical trial. Excluded from the definition of clinical research are in vitro studies that utilize human data or specimens that cannot be linked to a living individual and meet the requirements for exemption under 46.104(d)(4) of the Common Rule. The funding instrument for awards made under the program announcement will be cooperative agreements (31 USC 6305). Substantial CDMRP programmatic involvement with recipients is anticipated during the performance of award activities. Substantial involvement means that, after award, CDMRP staff will assist, guide, coordinate, or participate in project activities including but not limited to: Participating in the Steering Committee that oversees study conduct. Make recommendations for continued funding based on (a) overall study progress, including sufficient patient and/or data accrual; (b) cooperation in carrying out the research (e.g., attendance at Steering Committee meetings, implementation of group decisions, compliance with the terms of award and reporting requirements); and/or (c) maintenance of a high quality of research. The anticipated combined direct costs budgeted for the entire period of performance for a FY24 KCRP AKCI LA should not exceed $1,500,000. Refer to Section II.D.5, Funding Restrictions, for detailed funding information. Awards supported with FY24 funds will be made no later than September 30, 2025. The CDMRP expects to allot approximately $2.4M to fund approximately one KCRP Academy of Kidney Cancer Investigator Leadership Award application (consisting of an Initiating PI application and a Partnering PI application). Funding of applications received is contingent upon the availability of federal funds for this program, the number of applications received, the quality and merit of the applications as evaluated by peer and programmatic review, and the requirements of the government. Funds to be obligated on any award resulting from this funding opportunity will be available for use for a limited time period based on the fiscal year of the funds. It is anticipated that awards made from this FY24 funding opportunity will be funded with FY24 and FY26 funds, which will expire for use on September 30, 2030, and September 30, 2032, respectively.