Grants for Public and State controlled institutions of higher education - Federal

The purpose of this Notice of Funding Opportunity (NOFO) is to support the development of clinical research platforms that will enable future clinical trials to determine whether combinations of HIV cure strategies can be effective when optimally tailored to the participants. The ultimate goal is for the results of such proof-of-concept clinical studies to inform the development and prioritization of more broad-based curative strategies that will be effective in all people living with HIV. This NOFO will support multidisciplinary teams to conduct coordinated basic and pre-clinical research to profile participants intact, rebound-competent HIV reservoirs and immunologic backgrounds and use that information to develop and test combinations of HIV curative approaches that are specifically tailored to those participants.

Modified release (MR) oral drug products are considered to have a high risk for alcohol dose dumping (ADD) because they contain large quantities of drug(s), designed to release over a prolonged period of time. Accidental exposure of these products to alcohol can result in the relatively rapid release of large quantities of drug with severe side effects, including death. To mitigate this risk, the FDA recommends conducting an in vitro alcohol dose dumping assessment in 0%, 5%, 20%, and 40% alcoholic dissolution media for all prospective generic versions of MR oral drug products. To date, ADD assessments have not been harmonized globally. For instance, the U.S. FDA recommends testing up to 40% alcoholic media while the European Medicines Agency recommends testing up to 20% alcoholic media. This type of difference can present a challenge for formulators designing products for multiple markets, as historical data has shown release from MR oral products do not always follow a linear response (either increasing or decreasing) to increasing alcohol concentrations. In addition, interpretation of an ADD assessment may be limited by the inability of the test to predict in vivo behavior. The purpose of this research is to develop tools that 1) facilitate the development of MR generic drug products that have a low potential for ADD, 2) support regulatory decision making during the assessment of such products, and 3) provide evidence that enables FDA to develop more specific recommendations for efficiently demonstrating a low or comparative potential of alcohol dose dumping for MR oral drug products containing high risk drugs.

The FY24 DMDRP IDA promotes new ideas that are still in the early stages of development and have the potential to yield impactful data and new avenues of investigation. This award supports conceptually innovative, high-risk/high-reward research that could lead to critical discoveries or major advancements that will accelerate progress in improving outcomes for individuals with DMD. Applications should include a well-formulated, testable hypothesis based on strong scientific rationale.New Investigators: The FY24 DMDRP IDA mechanism encourages applications from independent investigators in the early stages of their careers (i.e., within 10 years of their first faculty appointment or equivalent) or applications from established investigators new to DMD research.The New Investigator Early Stage category is designed to allow applicants early in their faculty appointments to compete for funding separately from established investigators.The New Investigator Transitioning category is designed to allow investigators in an area other than muscular dystrophy, at or above the level of Assistant Professor, seeking to transition to a career in DMD, thereby bringing their expertise to the field.Applications from New Investigators and Established Investigators will be peer and programmatically reviewed separately. Principal Investigators (PIs) using the New Investigator Early Stage category or New Investigator Transitioning category are strongly encouraged to strengthen their applications by collaborating with investigators experienced in DMD research and/or possessing other relevant expertise. It is the responsibility of the applicant to describe how the included collaboration will augment the PIs expertise to best address the research question. All applicants for the New Investigator categories must meet the specific eligibility criteria described in Section II.C, Eligibility Information.Preliminary data relevant to DMD that supports the feasibility of the research hypotheses and research approaches are required. Preliminary data may include unpublished results from the laboratory of the PI, research team or collaborators named on the application.Key elements of this award are as follows:Innovation: Research deemed innovative may introduce a new paradigm, challenge current paradigms, look at existing problems from new perspectives, or exhibit other uniquely creative qualities.Impact: Research that has high potential impact may lead to major advancements and significantly accelerate progress toward improving outcomes for individuals with DMD.It is the responsibility of the PI to clearly and explicitly articulate the projects innovation and its potential impact on DMD. The projects impact to both DMD research and to individuals with DMD should be articulated, even if clinical impact is not an immediate outcome. Applications that demonstrate exceptional scientific merit but lack innovation and high potential impact do not meet the intent of the IDA.Clinical trials are not allowed under this funding opportunity.A clinical trial is defined in 45 CFR 46.102 as a research study in which one or more human subjects are prospectively assigned to one or more interventions (which may include a placebo or another control) to evaluate the effects of the interventions on biomedical or behavioral health-related outcomes.Studies that do not seek to measure safety, effectiveness, and/or efficacy outcome(s) of an intervention are not considered clinical trials.For the purposes of this funding opportunity, research that meets the definition of a clinical trial is distinct from clinical research. Clinical research encompasses research with human data, human specimens, and/or interaction with human subjects. Clinical research is observational in nature and includes:(1) Research conducted with human subjects and/or material of human origin such as data, specimens, and cognitive phenomena for which an investigator (or co-investigator) does not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention. Research meeting this definition may include but is not limited to: (a) mechanisms of human disease, (b) diagnostic or detection studies (e.g., biomarker or imaging), (c) health disparity studies, and (d) development of new technologies.(2) Epidemiologic and behavioral studies that do not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention.(3) Outcomes research and health services research that do not fit under the definition of clinical trial.Excluded from the definition of clinical research are in vitro studies that utilize human data or specimens that cannot be linked to a living individual and meet the requirements for exemption under 46.104(d)(4) of the Common Rule.

This funding opportunity supports organizations that empower women in El Salvador by providing professional development programs to enhance their business skills and promote economic growth.

This funding opportunity supports small-scale brain imaging research related to substance use and addiction, aimed at helping both new and established researchers develop innovative studies that enhance our understanding of neurobiological mechanisms in these areas.

This grant provides funding for academic training programs to develop skilled professionals in vocational rehabilitation, specifically targeting individuals who will support people with disabilities.

The "Model Intercomparison and Improvement for Carbon Sequestration and Greenhouse Gas Emission Estimation from Agriculture" grant is a $1.9 million funding opportunity from the U.S. Department of Agriculture aimed at supporting the coordination, implementation, and management of studies comparing different models of carbon sequestration and greenhouse gas emissions in agricultural systems, with a focus on soil carbon sequestration and emissions in cropland and grassland systems.

The Global Engagement Center seeks to support a third-party implementer to conduct a three-phase project to mitigate foreign influence efforts in Indonesia. The project implementer is expected to share findings through a publicly available report, partnered media reporting, and a series of briefings that integrate findings and propose actionable recommendations, with translation of published materials and public events into Indonesian.

This funding opportunity provides financial support to organizations and governments focused on implementing community-based restorative practices to address domestic violence, sexual assault, and stalking, promoting victim safety and accountability outside traditional legal systems.

This funding opportunity supports research teams from various sectors to explore how sex differences influence the biological factors related to Alzheimer’s disease and its treatment, aiming to enhance understanding and improve precision medicine approaches.

The U.S. Embassy Argentina Public Affairs Section (PAS) of the U.S. Department of State is pleased to announce its Public Diplomacy Annual Call for Strategic Programs. PAS will evaluate those proposals that focus exclusively on the development of one or more of the following strategic programs: A) International Visitor Leadership Program (IVLP) On Demand. B) Empowering Women Leaders in Congress and Local Legislatures C) Empowering Women Leaders in Argentine Labor Unions D) Academy of Women Entrepreneurs (AWE) E) Alumni Groups Meeting and Networking Event F) Argentina TESOL Annual Convention G) Empowering Youth program H) Promote Democracy Among Youth I) Study of the United States Program J) Bilingual Science Camp To apply, please read carefully the additional information contained in the documents attached.

ROGRAM DESCRIPTIONThe U.S. Embassy Nairobi, Public Diplomacy Section (PDS) of the U.S. Department of State is pleased to announce that funding is available through its Public Diplomacy Small Grants Program. This is an Annual Program Statement, outlining funding priorities, focus themes, and the procedures for submitting requests for funding. Please carefully follow all instructions below.Purpose of Small Grants: PDS Nairobi invites proposals for programs that strengthen ties between the United States and Kenya and promote bilateral cooperation. All programs must advance a U.S. linkage including for example a connection with American expert/s, organization/s, or institution/s in a specific field that will promote increased understanding of U.S. policies, economic models, and perspectives on U.S.-Kenya partnership.Priority Program Areas: Proposals must address one of the following key program areas:1. Economic Prosperity Advances the prosperity of the United States and Kenya through a fair and reciprocal economic partnership, the strengthening of Kenyas business climate, support for its startup ecosystem, clean energy solutions and climate change resiliency, and education that skills the next generation of workers. 2. Democracy and Governance Deepens the bilateral relationship on a broad range of common interests including the respect for human rights, safeguarding civic space, rule of law, public accountability, anti-corruption efforts, shared democratic values, and protection of fundamental freedoms.3. Celebrating 60 Years of U.S.-Kenya Partnership 2024 is the 60th anniversary of U.S.-Kenya ties, a milestone to celebrate as well as build upon. Amplify what the United States and Kenya are accomplishing together across various fields, including but not limited to the trade and investment partnership, climate action and renewable energy, public health advancements, education, shared values, and security cooperation. Participants and Audiences:Kenyans who may be in any of the following categories; Kenyans between the ages of 16 and 35, including students, civil society leaders and social influencers; Business leaders and rising entrepreneurs; Established opinion leaders, including cultural influencers and academic institution leadership.

The Administration for Children and Families (ACF) is soliciting applications for Secondary Analyses of Head Start Data awards. These awards aim to support researchers conducting secondary analyses of data of relevance to Head Start (HS) programs and policies. This includes research of relevance to HS programs serving families with children 3 to 5 years old, Early HS programs serving pregnant women and families with infants and toddlers, American Indian Alaska Native (AI/AN) HS programs serving families in tribal communities, and Migrant and Seasonal HS programs serving families engaged in migrant and seasonal farm work. The goals of the awards are to: 1) Address topics of current relevance to the goals and outcomes of HS programs; 2) Encourage active communication, networking, and collaboration among prominent HS researchers and policymakers; and 3) Increase the capacity of HS researchers to analyze existing data sets and disseminate their findings to multiple audiences. Topics and data sets of particular interest will be identified in the Notice of Funding Opportunity. Findings from these awards are intended to inform policy, program administration, and future research. If you are interested in this funding opportunity, please register at Grants.gov and subscribe to this forecast to receive update notifications.

This grant provides funding for innovative and high-risk technology development projects in biomedical research that are in the early exploratory stages and have not yet been proven feasible.

This funding opportunity provides financial support for research projects that aim to improve healthcare access and outcomes for individuals with disabilities by addressing the barriers they face in receiving necessary services.

The U.S. Department of Energys (DOE) Office of Energy Efficiency and Renewable Energy (EERE) Building Technologies Office (BTO) is issuing this Funding Opportunity Announcement (FOA) titled Bipartisan Infrastructure Law (BIL): Resilient and Efficient Codes Implementation (RECI). The current FOA represents the second installment in the RECI initiative, which maintains the same broad format, flexibility, and crosscutting areas of interest, while emphasizing and prioritizing specific gaps, needs, and opportunities to support building energy codes identified as focal points through the first RECI FOA and continued stakeholder engagement. The activities to be funded under the FOA support the BIL, as well as a broader government-wide approach to advance building codes and support their successful implementation. The primary focus centers around updating to more efficient building energy codes that save money for American homes and businesses, reduce greenhouse gas (GHG) emissions, and encourage more resilient buildings. This FOA includes one topic area broadly focused on the cost-effective implementation of updated energy codes.

This grant provides funding for state geological surveys to create detailed geologic maps that support economic development, environmental protection, and hazard mitigation across the nation.

This grant provides funding for innovative and high-risk research projects in biomedical, behavioral, or clinical fields, aimed at early-stage ideas that could lead to significant advancements.

This grant provides funding for nonprofit organizations and higher education institutions to create hands-on research projects that engage public health students in studying and addressing drug control policies and trends.

This funding opportunity supports researchers in discovering and validating new targets for developing safe and effective pain treatments with minimal side effects and low addiction risk.