Grants for Public and State controlled institutions of higher education - Federal

Reissue of RFA-NS-18-019: Understanding the dynamic activity of neural circuits is central to the NIH BRAIN Initiative. The invention, proof-of-concept investigation, and optimization of new technologies through iterative feedback from end users are key components of the BRAIN Initiative. This FOA seeks applications to optimize existing or emerging technologies through iterative testing with end users. The technologies and approaches should have potential to address major challenges associated with recording and modulation (including various modalities for stimulation/activation, inhibition and manipulation) of cells (i.e., neuronal and non-neuronal) and networks to enable transformative understanding of dynamic signaling in the central nervous system (CNS). These technologies and approaches should have previously demonstrated their transformative potential through initial proof-of-concept testing and are now ready for accelerated refinement. In conjunction, the manufacturing techniques should be scalable towards sustainable, broad dissemination and user-friendly incorporation into regular neuroscience research.Proposed technologies should be compatible with experiments in behaving animals, validated under in vivo experimental conditions, and capable of reducing major barriers to conducting neurobiological experiments and making new discoveries about the CNS. Technologies may engage diverse types of signaling beyond neuronal electrical activity such as optical, electrical, magnetic, acoustic or genetic recording/manipulation. Applications that seek to integrate multiple approaches are encouraged. If suitable, applications are expected to integrate appropriate domains of expertise, including biological, chemical and physical sciences, engineering, computational modeling and statistical analysis.

The "Clinical Studies of Orphan Products Addressing Unmet Needs of Rare Diseases (R01) Clinical Trials Required" grant aims to fund clinical trials that test the effectiveness and safety of new treatments for rare diseases, with the goal of increasing the number of approved treatments for these conditions.

Program Objectives: The program is meant to celebrate and support the bilateral MOU on cultural heritage protection agreement between the United States and Algeria (2024-2029). From October 2024 to March 2026, the grant should cover all costs associated with arranging of the visa, international and local travel, lodging, per diem, honoraria and events setting of a minimum of six experts priorly approved and or selected by the US Embassy in Algiers to visit Algeria for a minimum of a two days stay during which they will perform activities such as listed below but not limited to:o Conference about cultural heritage preservation best practiceso Algerian museums and cultural heritage site visitso Press conferenceso Pubic and digital outreach campaign Suggested time for travel: between 18 April 2025 - 18 May 2025 as it is Algerian Cultural Heritage Month Please note that funds transfer is not possible to Algerian officials nor to Algerian institutions. Participants and Audiences: Exchange participants should include American and foreign cultural heritage experts, community leaders, museums curators, researchers and scholars in the field. The intended target audiences are: Algerian government officials, Algerian cultural heritage experts, local community leaders, and Algerian public.B. FEDERAL AWARD INFORMATION Length of performance period: Up to 12 months Number of awards anticipated: 1 award Award amounts: $50,000 Total available funding: $50,000 Type of Funding: Smith-Mundt FY2024 Public Diplomacy funding Anticipated program start date: Fall 2024 This notice is subject to availability of funding. Funding Instrument Type: Grant or Cooperative Agreement Program Performance Period: Proposed programs should be completed in 12 months. C. ELIGILIBITY INFORMATION1. Eligible Applicants The following organizations are eligible to apply:Algerian U.S. and Foreign Institution of Higher EducationAlgerian U.S. and Foreign -based non-profit organizations/nongovernment organizations including think tanks and civil society and Social enterprises.Algerian and Foreign Public Entity, where permitted. U.S. and other countries public and private educational institutions. Individuals specialized in the field with required authorizations.2. Cost Sharing or Matching Cost sharing is not required.3. Other Eligibility Requirements In order to be eligible to receive an award, all organizations must have a Unique Entity Identifier (UEI) number issued via www.SAM.gov as well as a valid registration on www.SAM.gov. Please see Section D.3 for more information. Individuals are not required to have a UEI or be registered in SAM.gov. Organization are responsible to have or get all required authorizations to work in Algeria from local authorities and obtain authorization to work on the project for the execution phase.D. APPLICATION AND SUBMISSION INFORMATION1. Address to Request Application Package Application forms required below are available at https://dz.usembassy.gov/funding-opportunities_2024/ and Grnats.gov.2. Content and Form of Application Submission Please follow all instructions below carefully. Proposals that do not meet the requirements of this announcement or fail to comply with the stated requirements will be ineligible. Content of Application Please ensure: The proposal clearly addresses the goals and objectives of this funding opportunity All documents are in English All budgets are in U.S. dollars All documents are formatted to 8 x 11 paper, and All Microsoft Word documents are single-spaced, 12 point Calibri font, with a minimum of 1-inch margins. The following documents are required: 1. Mandatory application forms SF-424 (Application for Federal Assistance organizations), Instructions or SF-424-I , Instructions SF424A (Budget Information for Non-Construction programs), Instructions SF424B (Assurances for Non-Construction programs), Instructions2. Summary Page: Cover sheet stating the applicants name and organization, proposal date, program title, program period proposed start and end date, and brief purpose of the program.3. Proposal (3 pages maximum): The proposal should contain sufficient information that anyone not familiar with it would understand exactly what the applicant wants to do. You may use your own proposal format, but it must include all the items below. Proposal Summary: Short narrative that outlines the proposed program, including program objectives and anticipated impact. Introduction to the Organization or Individual applying: A description of past and present operations, showing ability to carry out the program, including information on all previous grants from the U.S. Embassy and/or U.S. government agencies. Problem Statement: Clear, concise and well-supported statement of the problem to be addressed and why the proposed program is needed Program Goals and Objectives: The goals describe what the program is intended to achieve. The objectives refer to the intermediate accomplishments on the way to the goals. These should be achievable and measurable.Program Activities: Describe the program activities and how they will help achieve the objectives. Program Methods and Design: A description of how the program is expected to work to solve the stated problem and achieve the goal. Include a logic model as appropriate. Proposed Program Schedule and Timeline: The proposed timeline for the program activities. Include the dates, times, and locations of planned activities and events. Key Personnel: Names, titles, roles and experience/qualifications of key personnel involved in the program. What proportion of their time will be used in support of this program? Program Partners: List the names and type of involvement of key partner organizations and sub-awardees. Program Monitoring and Evaluation Plan: This is an important part of successful grants. Throughout the time-frame of the grant, how will the activities be monitored to ensure they are happening in a timely manner, and how will the program be evaluated to make sure it is meeting the goals of the grant Future Funding or Sustainability Applicants plan for continuing the program beyond the grant period, or the availability of other resources, if applicable.4. Budget Justification Narrative: After filling out the SF-424A Budget (above), use a separate file to describe each of the budget expenses in detail.See section H. Other Information: Guidelines for Budget Submissions below for further information.5. Attachments: 1-page CV or resume of key personnel who are proposed for the program Letters of support from program partners describing the roles and responsibilities of each partner If your organization has a Negotiated Indirect Cost Rate Agreement (NICRA) and includes NICRA charges in the budget, your latest NICRA should be included as a PDF file.3. Unique Entity Identifier and System for Award Management (SAM.gov)

This grant provides funding for collaborative research teams to develop and test strategies that address and reduce racial and ethnic disparities in substance use and addiction, prioritizing community-driven issues.

The RFSP supports partnerships that connect public and private resources to plan and develop local or regional food systems. The RFSP focuses on building and strengthening local or regional food economy viability and resilience, and this includes pandemic response and recovery. Applicants will work with their partners to catalyze the development of local or regional food systems. Applicants will coordinate efforts within the partnership to set priorities, connect resources and services, and measure progress towards common goals. Partnerships are authorized to:Determine the size and scope of the local or regional food system in which the projects goals, outreach objectives, and eligible activities are to be carried out,Coordinate with AMS to receive technical assistance, andConduct outreach and education for potential participation in the partnership agreement and eligible activities.Partnerships must bring a variety of financial and technical capabilities, demonstrate experience or readiness to work effectively and collaboratively with public and private entities across sectors, and present innovative, sustainable, and measurable approaches to achieving the projects goals. RFSP grant recipients may apply for other LAMP programs on behalf of producers or eligible entities that desire to participate in eligible activities under the partnership agreement.

This grant provides funding for innovative researchers from various scientific fields to develop groundbreaking technologies for recording and manipulating neural activity in the nervous system.

The purpose of this funding opportunity is to support projects which enhance the quality, effectiveness and proven outcomes of nutrition services programs within the aging services network. The Older Americans Act (OAA) provides funding to States and Tribal Organizations to support a broad array of services that enable older adults to remain in their homes and communities and assist family and informal caregivers to care for their loved ones for as long as possible. More information is located here: https://acl.gov/programs/health-wellness/nutrition-services. Through this program, funds will be used to foster the development, testing and replication of innovative service delivery models, policies and partnerships that improve collaboration and coordination between OAA nutrition programs and multi-purpose senior centers. Projects proposed under this grant program must have the potential for broad implementation throughout the aging services network.

This funding opportunity provides financial support to non-profit organizations, educational institutions, and civil society groups in the U.S. and Argentina for projects that promote economic growth, good governance, and democratic principles in Argentina.

Grant Title: Towards a Better Understanding of the Neurological Effects of Infection-Associated Chronic Illnesses (R01 - Clinical Trial Optional) aims to support research on the neurological and mental health impacts of chronic illnesses triggered by infections, such as post-COVID conditions and myalgic encephalomyelitis, focusing on their underlying mechanisms and potential treatments.

As people harmed by domestic violence, dating violence, sexual assault, and stalking seek expanded options to address the harm they have experienced, communities have continued to strengthen and improve their responses, approaches, and services. One such approach is restorative practices. Restorative practices incorporate an understanding of trauma and are intended to repair and address the harm experienced while providing meaningful accountability for the harm-doer. An effective restorative practices program is completely voluntary for the person harmed, promotes their autonomy, and prioritizes their safety, while promoting meaningful justice, accountability, and community safety. The Violence Against Women Act Reauthorization Act of 2022, 34 U.S.C. 12514, authorizes funding to eligible entities to develop and implement a program, or to assess best practices for: 1) restorative practices to prevent or address domestic violence, dating violence, sexual assault, or stalking; 2) training by eligible entities, or for eligible entities, courts or prosecutors, on restorative practices and program implementation; and 3) evaluations of a restorative practice, as defined within the statute. Accordingly, OVW is launching the Restorative Practices Pilot Program in three (3) phases: 1) Training and Technical Assistance; 2) Evaluation; and 3) Pilot Sites. Phase 1: Training and Technical Assistance OVW issued the FY 2023 Restorative Practices Technical Assistance Pilot Program Call for Concept Papers in March 2023 to identify organizations with the requisite experience and capacity to provide Training and Technical Assistance (TTA) to recipients, subrecipients, and potential recipients and subrecipients of this program. Following an intensive review of responses to the Call for Concept Papers, OVW invited five entities to submit full applications. OVW issued awards to three of those applicants in March 2024 for five-year TTA projects that will run from April 2024 through March 2029 and will involve a planning phase. In addition to providing TTA to the pilot sites, the TTA providers will participate in evaluation efforts funded through the FY 2024 Restorative Practices Pilot Program Evaluation Solicitation. The TTA providers are funded under a separate funding announcement. This solicitation is exclusively intended to fund pilot sites of the Restorative Practices Pilot Sites Program. Phase 2: Evaluation In March 2024, OVW released the Restorative Practices Pilot Program Evaluation Solicitation to invite applications to conduct research and evaluation on restorative practices in collaboration with TTA providers and pilot sites. While pilot sites funded through this Restorative Practices Pilot Sites Program Solicitation will be required to provide funding for and designate an on-site Evaluation Liaison to work with evaluator(s) and participate in the community-tailored evaluation, the comprehensive evaluation will be funded under that separate funding announcement. This solicitation is exclusively intended to fund pilot sites of the Restorative Practices Pilot Sites Program. Phase 3: Pilot Sites (this solicitation) This Restorative Practices Pilot Sites Program is a 60-month funding opportunity seeking to support, strengthen, enhance, and expand existing restorative practice programs that prevent or address domestic violence, dating violence, sexual assault, or stalking, in accordance with the restorative practices definition at 34 U.S.C. 12514(a)(3), and build evidence for victim-centered, trauma-informed, and culturally responsive restorative practices addressing these harms. OVW will award cooperative agreements to eligible entities that form a partnership of two or more entities that have (1) a demonstrated history of comprehensive training and experience in working with victims of domestic violence, dating violence, sexual assault, or stalking; and (2) demonstrated experience in implementing restorative practices. OVW is interested in supporting communities to enhance or expand current efforts, including an evaluation of the intersection of domestic violence, dating violence, sexual assault, stalking and restorative practices. In addition, OVW seeks to fund a range of pilot sites, including sites in various geographic locations with different demographic characteristics; culturally specific, and/or underserved populations; and different VAWA subject areas to be addressed (i.e., domestic violence, dating violence, sexual assault, and/or stalking). OVW is interested in supporting projects that implement a diverse range of restorative practices, including projects that may have a connection to the criminal justice system, as long as the program is not housed within or administered by a court, prosecutors office, law enforcement agency, or any other component of the civil or criminal justice system. Recipients under this program will receive TTA for the duration of their awards that is tailored to the recipients distinct approach to restorative practices in domestic violence, dating violence, sexual assault, and stalking cases. Recipients will be required to collaborate with the evaluator(s) to help develop an understanding of establishing, implementing, and using restorative practices to redress the harm caused by domestic violence, dating violence, sexual assault, and stalking. The terms used throughout this solicitation may vary from people harmed, people who caused harm, harm-doers, victim, survivor, and offender, which reflects terminology used by practitioners and the statutory language that authorizes this program, 34 U.S.C. 12514.

This funding opportunity supports not-for-profit organizations, educational institutions, and individuals in fostering cultural, educational, and scientific collaborations between the United States and Oman.

This funding opportunity supports research into the biology and mechanisms of bladder cancer, encouraging multidisciplinary teams to explore both normal bladder functions and cancer processes using clinical specimens.

The OIA Technical Assistance Program 2025 provides funding for short-term projects that address immediate needs in U.S. insular areas, focusing on priorities like disaster response, climate change adaptation, and economic development, with awards ranging from $0 to $400,000.

To obtain a copy of the Funding Opportunity Announcement (FOA) please go to the ARPA-E website at https://arpa-e-foa.energy.gov. To apply to this FOA, Applicants must register with and submit application materials through ARPA-E eXCHANGE (https://arpa-e-foa.energy.gov/Registration.aspx). For detailed guidance on using ARPA-E eXCHANGE, please refer to the ARPA-E eXCHANGE User Guide (https://arpa-e-foa.energy.gov/Manuals.aspx). ARPA-E will not review or consider concept papers submitted through other means. For problems with ARPA-E eXCHANGE, email [email protected] (with FOA name and number in the subject line). Questions about this FOA? Check the Frequently Asked Questions available at http://arpa-e.energy.gov/faq. For questions that have not already been answered, email [email protected]. Agency Overview: The Advanced Research Projects Agency Energy (ARPA-E), an organization within the Department of Energy (DOE), is chartered by Congress in the America COMPETES Act of 2007 (P.L. 110-69), as amended by the America COMPETES Reauthorization Act of 2010 (P.L. 111-358), as further amended by the Energy Act of 2020 (P.L. 116-260) to: (A) to enhance the economic and energy security of the United States through the development of energy technologies that (i) reduce imports of energy from foreign sources; (ii) reduce energy-related emissions, including greenhouse gases; (iii) improve the energy efficiency of all economic sectors; (iv) provide transformative solutions to improve the management, clean-up, and disposal of radioactive waste and spent nuclear fuel; and (v) improve the resilience, reliability, and security of infrastructure to produce, deliver, and store energy; and (B) to ensure that the United States maintains a technological lead in developing and deploying advanced energy technologies. ARPA-E issues this Funding Opportunity Announcement (FOA) under its authorizing statute codified at 42 U.S.C. 16538. The FOA and any awards made under this FOA are subject to 2 C.F.R. Part 200 as supplemented by 2 C.F.R. Part 910. ARPA-E funds research on and the development of transformative science and technology solutions to address the energy and environmental missions of the Department. The agency focuses on technologies that can be meaningfully advanced with a modest investment over a defined period of time in order to catalyze the translation from scientific discovery to early-stage technology. For the latest news and information about ARPA-E, its programs and the research projects currently supported, see: http://arpa-e.energy.gov/. ARPA-E funds transformational research. Existing energy technologies generally progress on established learning curves where refinements to a technology and the economies of scale that accrue as manufacturing and distribution develop drive down the cost/performance metric in a gradual fashion. This continual improvement of a technology is important to its increased commercial deployment and is appropriately the focus of the private sector or the applied technology offices within DOE. By contrast, ARPA-E supports transformative research that has the potential to create fundamentally new learning curves. ARPA-E technology projects typically start with cost/performance estimates well above the level of an incumbent technology. Given the high risk inherent in these projects, many will fail to progress, but some may succeed in generating a new learning curve with a projected cost/performance metric that is significantly lower than that of the incumbent technology. ARPA-E funds technology with the potential to be disruptive in the marketplace. The mere creation of a new learning curve does not ensure market penetration. Rather, the ultimate value of a technology is determined by the marketplace, and impactful technologies ultimately become disruptive that is, they are widely adopted and displace existing technologies from the marketplace or create entirely new markets. ARPA-E understands that definitive proof of market disruption takes time, particularly for energy technologies. Therefore, ARPA-E funds the development of technologies that, if technically successful, have clear disruptive potential, e.g., by demonstrating capability for manufacturing at competitive cost and deployment at scale. ARPA-E funds applied research and development. The Office of Management and Budget defines applied research as an original investigation undertaken in order to acquire new knowledgedirected primarily towards a specific practical aim or objective and defines experimental development as creative and systematic work, drawing on knowledge gained from research and practical experience, which is directed at producing new products or processes or improving existing products or processes. (http://science.energy.gov/). Office of Science national scientific user facilities (http://science.energy.gov/user-facilities/) are open to all researchers, including ARPA-E Applicants and awardees. These facilities provide advanced tools of modern science including accelerators, colliders, supercomputers, light sources and neutron sources, as well as facilities for studying the nanoworld, the environment, and the atmosphere. Projects focused on early-stage R for the improvement of technology along defined roadmaps may be more appropriate for support through the DOE applied energy offices including: the Office of Energy Efficiency and Renewable Energy (http://www.eere.energy.gov/), the Office of Fossil Energy (http://fossil.energy.gov/), the Office of Nuclear Energy (http://www.energy.gov/ne/office-nuclear-energy), and the Office of Electricity Delivery and Energy Reliability (http://energy.gov/oe/office-electricity-delivery-and-energy-reliability). Applicants interested in receiving financial assistance for basic research (defined by the Office of Management and Budget as experimental or theoretical work undertaken primarily to acquire new knowledge of the underlying foundations of phenomena and observable facts) should contact the DOEs Office of Science (http://science.energy.gov/). Office of Science national scientific user facilities (http://science.energy.gov/user-facilities/) are open to all researchers, including ARPA-E Applicants and awardees. These facilities provide advanced tools of modern science including accelerators, colliders, supercomputers, light sources and neutron sources, as well as facilities for studying the nanoworld, the environment, and the atmosphere. Projects focused on early-stage R for the improvement of technology along defined roadmaps may be more appropriate for support through the DOE applied energy offices including: the Office of Energy Efficiency and Renewable Energy (http://www.eere.energy.gov/), the Office of Fossil Energy (http://fossil.energy.gov/), the Office of Nuclear Energy (http://www.energy.gov/ne/office-nuclear-energy), and the Office of Electricity Delivery and Energy Reliability (http://energy.gov/oe/office-electricity-delivery-and-energy-reliability). Program Overview: The Creating Hardened And Durable fusion first Wall Incorporating Centralized Knowledge (CHADWICK) program will pursue discovery and testing of novel, first-wall materials that will maintain design performance over the target 40-year design lifetime of a fusion power plant. In most fusion power systems, the fusion reactions are physically contained by the first wall. The first wall bears the mechanical load and protects the components from the extreme heat and highly energetic charged and neutral particles. The safety and structural performance of the first wall are compromised over time by significant exposure to high-energy (;gt;1 million electron volts (MeV)) neutrons and heat flux as much as 10 megawatts per square meter (MW/m2)). As fusion energy advances towards commercial deployment, the lifetime and maintainability of first-wall materials will become a major challenge for the commercial viability of fusion power plants with high neutron flux. Thermal effects on materials are relatively well understood. However, the combination of heat plus an intense neutron environment can generate many nonlinear effects that are difficult to predict. Radiation most commonly damages a material by driving atomic displacements and the transmuting of isotopes within the material structure. Some transmutation events encourage the development of activation product gasses, such as hydrogen and helium, which encourage wall swelling. The combination of stresses caused by atomic dislocations, swelling, and thermal contraction and expansion drive material hardening and embrittlement, ultimately promoting premature cracking and failure. The most common descriptor for radiation damage is displacements per atom (dpa). These displacements can cause irradiation embrittlement leading to the loss of ductility in a material after exposure to radiation. Fusion power plant first-wall materials are anticipated to experience ;gt;50 dpa over the desired 40-year operational period. Radiation damage has been observed to harden and embrittle first-wall materials at levels as low as 5 dpa. The goal of the CHADWICK program is the discovery, development, and production of new materials that can maintain the following metrics in a fusion first-wall environment: Room temperature ductility after 50 dpa of irradiation damage and helium generation; Sufficiently high thermal conductivity to remove up to 10 MW/m2 of heat; Activation below 10,000 Sieverts per hour (Sv/hr) to enable remote handling; Swelling below 1% to maintain dimensional stability; and Tritium retention and plasma erosion lower than current state-of-the-art (SoA) materials. SoA materials under consideration for fusion first-wall applications are currently limited to reduced activation ferritic martensitic (RAFM) steels and tungsten.7 Both materials suffer from irradiation and helium embrittlement issues that make fusion power plants prohibitively expensive to qualify and operate. New materials that are highly resistant or functionally immune to irradiation embrittlement up to 50 dpa can increase the lifetime of the first wall by a factor of 10. These materials are envisioned to be essential to the deployment of sustained and economical fusion energy. To view the FOA in its entirety, please visit https://arpa-e-foa.energy.gov.

This funding opportunity provides financial support for conservation projects aimed at protecting candidate and at-risk species in the U.S., targeting a wide range of eligible applicants including governments, non-profits, and individuals.

The purpose of the NIH Mentored Research Scientist Development Award (K01) is to provide support and protected time (three to five years) for an intensive, supervised career development experience in the biomedical, behavioral, or clinical sciences leading to research independence. Although all of the participating NIH Institutes and Centers (ICs) use this support mechanism to support career development experiences that lead to research independence, some ICs use the K01 award for individuals who propose to train in a new field or for individuals who have had a hiatus in their research career because of illness or pressing family circumstances. Other ICs offer separate K01 FOAs intended to increase research workforce diversity.

This funding opportunity supports innovative, early-stage research involving human participants to advance biomedical and clinical science, targeting a wide range of eligible applicants including universities, nonprofits, and small businesses.

This grant provides funding to support postdoctoral researchers from diverse backgrounds as they transition into independent faculty positions in biomedical research.

The purpose of this research is to systematically evaluate the diastereomeric composition of LEQVIO (Inclisiran), an FDA-approved, N-acetyl galactosamine (GalNAc)-conjugated siRNA drug, and to understand the biological/pharmacological activity of each diastereomer in LEQVIO through stereo chemically controlled synthesis and biological activity assessment using in vitro and animal models. The proposed studies will focus on 1) synthesis of each diastereomer of LEQVIO (Inclisiran) in stereo chemically pure form; 2) assessment of the biological activity of each stereo chemically pure diastereomer in inhibiting PCSK9 activity using in vitro assays and in a transgenic mouse model; 3) development of analytical methods to identify and characterize the stereochemical structure of each diastereomer in LEQVIO; and 4) assessment of the individual contribution of each diastereomer to the overall pharmacological activity of LEQVIO. Tools developed in this research can also be applied to other similar GalNAc-conjugated siRNAs specifically, and other siRNAs in general. Knowledge gained from this research will also contribute to the sameness evaluation of generic siRNAs, and to the quality control of oligonucleotide drugs.

This opportunity seeks input from organizations involved in maternal and child health projects to help improve healthcare quality for the poorest and most vulnerable populations in Indonesia.