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Grants for Small businesses - Federal

Explore 1,549 grant opportunities

High Energy Cost Grants
$3,000,000
U.S. Department of Agriculture (Rural Utilities Service)
Federal

Application Deadline

Feb 28, 2025

Date Added

Dec 30, 2024

This program provides funding to communities facing extremely high energy costs to improve their energy infrastructure and promote renewable energy solutions.

Business and Commerce
State governments
Notice of Intent to Publish a Funding Opportunity Announcement for Precision Medicine for Type 1 Diabetic Nephropathy (U01 Clinical Trial Not Allowed)
$1,300,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Dec 10, 2024

Date Added

Sep 27, 2024

This funding opportunity is designed to support research sites that will enroll patients with Type 1 Diabetes at risk of kidney disease, enabling the study of kidney biopsies to advance understanding and treatment of diabetic nephropathy.

Health
State governments
Infrastructure Investment and Jobs Act (IIJA): Mine of the Future - Proving Ground Initiative
$40,000,000
U.S. Department of Energy (National Energy Technology Laboratory)
Federal

Application Deadline

Jan 30, 2026

Date Added

Nov 17, 2025

This funding opportunity provides financial support for the establishment of national-scale testing facilities for innovative mining technologies, aimed at enhancing the U.S. critical minerals supply chain through collaborative projects among academia, industry, and other stakeholders.

Natural Resources
Public and State controlled institutions of higher education
Private Sector Collaboration Pathway (PSCP) Jordan Addendum
$10,000,000
Agency for International Development (Jordan USAID-Amman)
Federal

Application Deadline

Apr 26, 2025

Date Added

Apr 17, 2024

This initiative provides funding opportunities for private sector entities in Jordan to collaborate with USAID in addressing key development challenges, focusing on economic growth, water security, governance, education, and the empowerment of women and youth.

Business and Commerce
For profit organizations other than small businesses
ClinGen Genomic Curation Expert Panels (U24 Clinical Trial Not Allowed)
$220,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

May 25, 2025

Date Added

Jun 6, 2023

This funding opportunity provides financial support for research organizations to establish expert panels that will evaluate and curate genomic variants linked to important diseases, enhancing clinical understanding and treatment options.

Education
State governments
Solutions to Enable Regional Genomic Medicine eConsult Services (R43/R44 Clinical Trial Optional)
$400,000
HHS-NIH11 (National Institutes of Health)
Federal

Application Deadline

May 30, 2024

Date Added

Jan 9, 2024

This Notice of Funding Opportunity (NOFO) invites applications from eligible small businesses to develop solutions for commercialization that can be used to enable regional clinician-to-clinician genomic medicine eConsult services. Specifically, we seek products, such as technologies or services, that will allow for the development and sustainment of eConsult services. Eligible United States small business concerns (SBCs) may submit Small Business Innovation Research (SBIR) Phase I, Direct to Phase II, and Fast-Track grant applications. Small business applicants interested in submitting a Small Business Technology Transfer (STTR) grant application should submit to the related funding opportunity, PAR-24-107. SBIR and STTR are phased programs. The main objective in SBIR and STTR Phase I is to establish the technical merit and feasibility of the proposed research and development efforts. An SBIR and STTR Phase II continues the R&D efforts to advance the technology toward ultimate commercialization. At the conclusion of an SBIR/STTR Phase II, it is expected that the small business will fully commercialize their product or technology using non-SBIR/STTR funds (either federal or non-federal). Small businesses that are eligible to submit Phase II applications for projects that were supported with a Phase I SBIR or STTR award are expected to submit the regular Phase II application as a "Renewal" application based on the awarded Phase I SBIR or STTR project. Only one Phase II application may be awarded for a specific project supported by a Phase I award. NIH Fast-Track: An NIH SBIR Fast-Track incorporates a submission and review process in which both Phase I and Phase II applications are submitted and reviewed together as one application to reduce or eliminate the funding gap between phases. NIH Direct to Phase II: For small businesses that have already demonstrated scientific and technical merit and feasibility but have not received a Phase I SBIR or STTR for that project, NIH can issue a Direct to Phase II award. The NIH will accept Direct to Phase II applications regardless of the funding source for the proof of principle work on which the proposed Phase II research is based. Direct to Phase II awards should be submitted as “New” applications and not continuations ("Renewal") of Phase I SBIR or STTR projects.

Health
Small businesses
FY2025 Commercial Motor Vehicle Operator Safety Training Program (CMVOST)
$200,000
U.S. Department of Transportation (DOT-Federal Motor Carrier Safety Administration)
Federal

Application Deadline

Jun 20, 2025

Date Added

May 22, 2025

This funding opportunity provides financial support to educational institutions and training providers for training individuals, especially veterans and their families, in the safe operation of commercial motor vehicles to help them obtain their Commercial Driver’s Licenses.

Transportation
State governments
Strengthening comprehensive HIV prevention interventions in Malawi under the President's Emergency Plan for AIDS Relief (PEPFAR)
$5,000,000
U.S. Department of Health & Human Services (Centers for Disease Control-GHC)
Federal

Application Deadline

Feb 18, 2025

Date Added

Jul 18, 2024

This funding opportunity provides financial support to organizations working in Malawi to implement comprehensive HIV prevention strategies, focusing on reducing new infections and improving health outcomes for targeted populations.

Health
State governments
NIAID SBIR Phase II Clinical Trial Implementation Cooperative Agreement (U44 Clinical Trial Required)
Contact for amount
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Nov 17, 2025

Date Added

Jan 30, 2024

This funding opportunity provides financial support for small businesses to conduct innovative clinical trials related to allergy and infectious diseases, focusing on high-risk studies and unlicensed products.

Health
Small businesses
DoD Melanoma, Team Science Award
$2,100,000
U.S. Department of Defense (Dept. of the Army -- U.S.AMRAA)
Federal

Application Deadline

Oct 1, 2025

Date Added

May 27, 2025

This grant provides funding for collaborative research teams of independent investigators to advance innovative solutions in melanoma prevention, treatment, and survivorship, with a focus on improving patient outcomes.

Science and Technology
Nonprofits
Community-led Monitoring of Integrated Primary Health Care Services Activity (INTEG-CLM-PHC) in Togo
$2,400,000
U.S. Agency for International Development (Ghana USAID-Accra)
Federal

Application Deadline

Not specified

Date Added

Aug 22, 2024

This grant provides funding to improve primary health care services in Togo by enhancing their quality and community responsiveness, particularly for vulnerable groups like women, children, and people living with HIV/AIDS.

Health
Individuals
DoD Tick-Borne Disease, Idea Development Award
$3,640,000
U.S. Department of Defense (Dept. of the Army -- U.S.AMRAA)
Federal

Application Deadline

Oct 3, 2024

Date Added

Apr 24, 2024

The DoD Tick-Borne Disease, Idea Development Award is a grant aimed at funding innovative research that could significantly advance the understanding and treatment of Lyme disease and other tick-borne diseases, ultimately improving the lives of military personnel, veterans, their families, and the general public.

Science and Technology
Nonprofits
ROSES 2024: F.9 Citizen Science Seed Funding Program
$700,000
National Aeronautics & Space Administration (NASA Headquarters)
Federal

Application Deadline

Nov 19, 2024

Date Added

Feb 15, 2024

This funding opportunity is designed to support innovative citizen science projects that engage the public in space and Earth science research, encouraging collaboration between scientists and community members.

Science and Technology
Nonprofits
Stimulate Utilization of Plentiful Energy in Rocks through High-temperature Original Technologies SBIR/STTR (SUPERHOT SBIR/STTR)
$4,505,859
U.S. Department of Energy (Advanced Research Projects Agency Energy )
Federal

Application Deadline

Mar 5, 2026

Date Added

Jan 29, 2026

This funding opportunity provides financial support to small businesses developing innovative technologies to harness superhot geothermal energy, aiming to create sustainable and cost-effective electricity generation systems.

Opportunity Zone Benefits
Small businesses
Sedimentary Geology and Paleobiology
$10,400,000
National Science Foundation
Federal
Rolling

Application Deadline

Not specified

Date Added

May 14, 2022

This grant provides funding for researchers studying ancient sediments and fossils to better understand the Earth's history, environmental changes, and the evolution of life before the Holocene epoch.

Science and Technology
For profit organizations other than small businesses
Federal And State Technology (FAST) Partnership Program Fy 2024
$200,000
SBA (Small Business Administration)
Federal

Application Deadline

Jun 20, 2024

Date Added

May 21, 2024

The Federal and State Technology (FAST) Partnership Program provides funding to organizations to execute state/regional programs that increase the number of SBIR/STTR proposals leading to an increase in the number of SBIR/STTR awards from women, socially/economically disadvantaged individuals, and small businesses in underrepresented areas - typically rural states.

Business and Commerce
State governments
Notice of Intent to Publish a Funding Opportunity Announcement: Technology Development to Reduce Health Disparities (R01 Clinical Trial Optional)
$1,200,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jan 26, 2026

Date Added

May 22, 2025

This funding opportunity provides financial support for the development of affordable and culturally appropriate biomedical technologies aimed at reducing healthcare disparities among underserved populations in the United States.

Health
State governments
DRL Supporting Solomon Islands Youth Leadership in Politics and Civics
$1,000,000
DOS-DRL (Bureau of Democracy Human Rights and Labor)
Federal

Application Deadline

Jul 12, 2024

Date Added

Jun 11, 2024

The U.S. Department of State, Bureau of Democracy, Human Rights, and Labor (DRL) announces an open competition for organizations interested in submitting applications for a project that supports the meaningful political and civic participation of youth in the Solomon Islands.

International Development
Nonprofits
Printed Circuit Boards (PCB) Workforce Development Program
$250,000
U.S. Department of State - U.S. Mission to Mexico
Federal

Application Deadline

Jul 31, 2024

Date Added

Jun 27, 2024

U.S. Embassy Mexico City of the U.S. Department of State announces an open competition for organizations to submit applications to carry out a program to promote workforce development in the printed circuit board (PCB) industry through curriculum development for PCB focused courses at secondary and tertiary educational levels, certificate programs, vocational instruction, dual education, technical English language skills building, and full or partial support for internships in Taiwanese PCB manufacturing firms either in Taiwan or Mexico.

International Development
Nonprofits
Blueprint Neurotherapeutics Network (BPN): Small Molecule Drug Discovery and Development for Disorders of the Nervous System (U44 Clinical Trial Optional)
Contact for amount
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Nov 17, 2025

Date Added

Nov 1, 2023

This funding opportunity provides financial support to U.S.-based small businesses and academic researchers for the discovery and development of small molecule drugs targeting disorders of the nervous system.

Education
Small businesses