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Grants for Small businesses - Federal

Explore 1,502 grant opportunities

Notice of Intent to Publish a Notice of Funding Opportunity (NOFO) for High-Priority Research in Tobacco Regulatory Science (R01 Clinical Trial Optional)
$500,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Jun 5, 2025

Date Added

Oct 25, 2024

This funding opportunity provides up to $500,000 for researchers to conduct innovative studies that inform tobacco product regulation and public health, with a focus on understanding tobacco use, its health effects, and addiction.

Health
State governments
Mexico CDCS Annual Program Statement
$100,000,000
Agency for International Development (Mexico U.S.AID-Mexico City)
Federal

Application Deadline

May 2, 2025

Date Added

Jan 24, 2025

This funding opportunity is designed to support a variety of organizations, particularly local Mexican entities, in implementing projects that align with USAID's development goals in Mexico over a period of up to five years.

International Development
Nonprofits
Human Virome Program: Developing novel and innovative tools to interrogate and annotate the human virome (U01 Clinical Trial Not Allowed)
$350,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Feb 27, 2025

Date Added

Oct 24, 2024

This funding opportunity supports the development of innovative tools and methodologies to study the human virome, inviting a diverse range of organizations to enhance our understanding of how viruses impact human health and disease.

Health
State governments
Integrated Functional Mapping and Molecular Profiling of Cell Ensembles Encoding the Effects of Addictive Substances in Rodents (R01 Clinical Trial Not Allowed)
$700,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Feb 23, 2026

Date Added

Feb 12, 2025

This funding opportunity supports research institutions and organizations in developing innovative technologies to study how neural cell groups in rodents respond to addictive substances, aiming to deepen our understanding of addiction-related behaviors.

Education
State governments
ROSES 2024: A.50 Citizen Science for Earth Systems Program
$300,000
NASA-HQ (NASA Headquarters)
Federal

Application Deadline

May 14, 2024

Date Added

Feb 15, 2024

PLEASE NOTE: this program has MANDATORY Notices of Intent, which are due via NSPIRES by April 15, 2024. See the full posting on NSPIRES for details. Proposers must retrieve the instructions document (zip file) associated with the application package for this opportunity as there is at least one required form that must be attached to the submitted proposal package. The National Aeronautics and Space Administration (NASA) Science Mission Directorate (SMD) released its annual omnibus Research Announcement (NRA), Research Opportunities in Space and Earth Sciences (ROSES) 2024 (OMB Approval Number 2700-0092, CFDA Number 43.001) on February 14, 2024. In this case "omnibus" means that this NRA has many individual program elements, each with its own due dates and topics. All together these cover the wide range of basic and applied supporting research and technology in space and Earth sciences supported by SMD. Awards will be made as grants, cooperative agreements, contracts, and inter- or intra-agency transfers, depending on the nature of the work proposed, the proposing organization, and/or program requirements. However, most extramural research awards deriving from ROSES will be grants, and many program elements of ROSES specifically exclude contracts, because contracts would not be appropriate for the nature of the work solicited. The typical period of performance for an award is three years, but some programs may allow up to five years and others specify shorter periods. In most cases, organizations of every type, Government and private, for profit and not-for-profit, domestic and foreign (with some caveats), may submit proposals without restriction on teaming arrangements. Tables listing the program elements and due dates (Tables 2 and 3), a table that provides a very top level summary of proposal contents (Table 1), and the full text of the ROSES-2024 "Summary of Solicitation", may all be found NSPIRES at http://solicitation.nasaprs.com/ROSES2024. This synopsis is associated with one of the individual program elements within ROSES, but this is a generic summary that is posted for all ROSES elements. For specific information on this particular program element download and read the PDF of the text of this program element by going to Tables 2 or 3 of this NRA at http://solicitation.nasaprs.com/ROSES2024table2 and http://solicitation.nasaprs.com/ROSES2024table3, respectively, click the title of the program element of interest, a hypertext link will take you to a page for that particular program element. On that page, on the right side under "Announcement Documents" the link on the bottom will be to the PDF of the text of the call for proposals. For example, if one were interested in The Lunar Data Analysis Program (NNH24ZDA001N-LDAP) one would follow the link to the NSPIRES page for that program element and then to read the text of the call one would click on C.8 Lunar Data Analysis Program (.pdf) to download the text of the call. If one wanted to set it into the context of the goals, objectives and know the default rules for all elements within Appendix C, the planetary science division, one might download and read C.1 Planetary Science Research Program Overview (.pdf) from that same page. While the letters and numbers are different for each element within ROSES (A.12, B.7, etc.) the basic configuration is always the same, e.g., the letter indicates the Science Division (A is Earth Science, B is Heliophysics etc.) and whatever the letter, #1 is always the division overview. Frequently asked questions for ROSES are posted at http://science.nasa.gov/researchers/sara/faqs. Questions concerning general ROSES-2024 policies and procedures may be directed to Max Bernstein, Lead for Research, Science Mission Directorate, at [email protected], but technical questions concerning specific program elements should be directed to the point(s) of contact for that particular element, who may be found either at the end of the individual program element in the summary table of key information or on the web list of topics and points of contact at: http://science.nasa.gov/researchers/sara/program-officers-list. Not all program elements are known at the time of the release of ROSES. To be informed of new program elements or amendments to this NRA, proposers may subscribe to: (1) The SMD mailing lists (by logging in at http://nspires.nasaprs.com and checking the appropriate boxes under "Account Management" and "Email Subscriptions"), (2) The ROSES-2024 blog feed for amendments, clarifications, and corrections to at https://science.nasa.gov/researchers/solicitations/roses-2024/, and (3) The ROSES-2024 due date Google calendars (one for each science division). Instructions are at https://science.nasa.gov/researchers/sara/library-and-useful-links (link from the words due date calendar).

Science and Technology
Nonprofits
Rural Energy for America Program
$1,000,000
U.S. Department of Agriculture (Rural BU.S.iness-Cooperative Service)
Federal

Application Deadline

Sep 30, 2024

Date Added

Apr 14, 2023

The Rural Business-Cooperative Service is offering a $1.055 billion grant under the Rural Energy for America Program for qualifying renewable energy and energy efficiency projects, with a maximum grant request of $1 million for renewable systems and $500,000 for energy efficiency improvements.

Energy
Small businesses
DoD Melanoma, Survivorship Research Award
$1,015,000
U.S. Department of Defense (Dept. of the Army -- U.S.AMRAA)
Federal

Application Deadline

Oct 1, 2025

Date Added

May 27, 2025

This funding opportunity supports innovative research aimed at improving the quality of life for melanoma survivors and their families through evidence-based practices and psychosocial interventions.

Science and Technology
Nonprofits
ROSES 2024: A.17 Atmospheric Composition: Upper Atmospheric Composition Observations
Contact for amount
National Aeronautics & Space Administration (NASA Headquarters)
Federal

Application Deadline

Sep 19, 2024

Date Added

Feb 15, 2024

Please note that this program requests optional Notices of Intent, which are due via NSPIRES by July 19, 2024. See the full posting on NSPIRES for details. Proposers must retrieve the instructions document (zip file) associated with the application package for this opportunity as there is at least one required form that must be attached to the submitted proposal package. The National Aeronautics and Space Administration (NASA) Science Mission Directorate (SMD) released its annual omnibus Research Announcement (NRA), Research Opportunities in Space and Earth Sciences (ROSES) 2024 (OMB Approval Number 2700-0092, CFDA Number 43.001) on February 14, 2024. In this case "omnibus" means that this NRA has many individual program elements, each with its own due dates and topics. All together these cover the wide range of basic and applied supporting research and technology in space and Earth sciences supported by SMD. Awards will be made as grants, cooperative agreements, contracts, and inter- or intra-agency transfers, depending on the nature of the work proposed, the proposing organization, and/or program requirements. However, most extramural research awards deriving from ROSES will be grants, and many program elements of ROSES specifically exclude contracts, because contracts would not be appropriate for the nature of the work solicited. The typical period of performance for an award is three years, but some programs may allow up to five years and others specify shorter periods. In most cases, organizations of every type, Government and private, for profit and not-for-profit, domestic and foreign (with some caveats), may submit proposals without restriction on teaming arrangements. Tables listing the program elements and due dates (Tables 2 and 3), a table that provides a very top level summary of proposal contents (Table 1), and the full text of the ROSES-2024 "Summary of Solicitation", may all be found NSPIRES at http://solicitation.nasaprs.com/ROSES2024. This synopsis is associated with one of the individual program elements within ROSES, but this is a generic summary that is posted for all ROSES elements. For specific information on this particular program element download and read the PDF of the text of this program element by going to Tables 2 or 3 of this NRA at http://solicitation.nasaprs.com/ROSES2024table2 and http://solicitation.nasaprs.com/ROSES2024table3, respectively, click the title of the program element of interest, a hypertext link will take you to a page for that particular program element. On that page, on the right side under "Announcement Documents" the link on the bottom will be to the PDF of the text of the call for proposals. For example, if one were interested in The Lunar Data Analysis Program (NNH24ZDA001N-LDAP) one would follow the link to the NSPIRES page for that program element and then to read the text of the call one would click on C.8 Lunar Data Analysis Program (.pdf) to download the text of the call. If one wanted to set it into the context of the goals, objectives and know the default rules for all elements within Appendix C, the planetary science division, one might download and read C.1 Planetary Science Research Program Overview (.pdf) from that same page. While the letters and numbers are different for each element within ROSES (A.12, B.7, etc.) the basic configuration is always the same, e.g., the letter indicates the Science Division (A is Earth Science, B is Heliophysics etc.) and whatever the letter, #1 is always the division overview. Frequently asked questions for ROSES are posted at http://science.nasa.gov/researchers/sara/faqs. Questions concerning general ROSES-2024 policies and procedures may be directed to Max Bernstein, Lead for Research, Science Mission Directorate, at [email protected], but technical questions concerning specific program elements should be directed to the point(s) of contact for that particular element, who may be found either at the end of the individual program element in the summary table of key information or on the web list of topics and points of contact at: http://science.nasa.gov/researchers/sara/program-officers-list. Not all program elements are known at the time of the release of ROSES. To be informed of new program elements or amendments to this NRA, proposers may subscribe to: (1) The SMD mailing lists (by logging in at http://nspires.nasaprs.com and checking the appropriate boxes under "Account Management" and "Email Subscriptions"), (2) The ROSES-2024 blog feed for amendments, clarifications, and corrections to at https://science.nasa.gov/researchers/solicitations/roses-2024/, and (3) The ROSES-2024 due date Google calendars (one for each science division). Instructions are at https://science.nasa.gov/researchers/sara/library-and-useful-links (link from the words due date calendar).

Science and Technology
Nonprofits
DoD Rare Cancers, Resource and Community Development Award
$1,120,000
U.S. Department of Defense (Dept. of the Army -- U.S.AMRAA)
Federal

Application Deadline

Oct 6, 2025

Date Added

May 2, 2025

This funding opportunity supports the development of research resources and community engagement initiatives to improve outcomes for individuals affected by rare cancers, requiring active involvement from patient advocates throughout the project.

Science and Technology
Nonprofits
BRAIN Initiative: Brain-Behavior Quantification and Synchronization Transformative and Integrative Models of Behavior at the Organismal Level (U01 Clinical Trials Not Allowed)
$8,000,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

May 23, 2025

Date Added

May 31, 2024

This funding opportunity supports innovative research teams using non-human animal models to develop advanced methods for measuring and analyzing behavior in relation to environmental factors.

Education
State governments
Dual-Use University Accelerator Challenge
$500,000
Defense Innovation Unit
Federal

Application Deadline

Jun 25, 2025

Date Added

Jun 2, 2025

This grant supports early-stage university-affiliated startups developing dual-use technologies that can benefit both commercial markets and the Department of Defense, providing funding, mentorship, and resources to help them engage with defense opportunities.

Science and Technology
For profit organizations other than small businesses
NIDCR Small Research Grants for Analyses of Existing Genomics Data (R03 Clinical Trial Not Allowed)
$100,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jan 7, 2025

Date Added

Mar 28, 2023

This funding opportunity supports small-scale research projects that analyze existing genomic data to advance understanding of dental, oral, and craniofacial health, particularly focusing on health disparities and biological pathways for intervention.

Health
State governments
Translational Research Toward Development of a Kaposi Sarcoma Herpesvirus (KSHV) Vaccine (U01 Clinical Trial Optional)
$500,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Dec 4, 2024

Date Added

Oct 16, 2023

This grant provides funding for researchers to develop a vaccine against Kaposi sarcoma herpesvirus (KSHV), aiming to prevent infection and treat related diseases in affected populations.

Education
State governments
Notice of Intent to Publish a Funding Opportunity Announcement for Accelerating the Pace of Substance Use Research Using Existing Data (R21 Clinical Trial Not Allowed)
$200,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Jun 17, 2025

Date Added

Oct 25, 2024

This funding opportunity provides financial support for researchers to utilize existing data to advance studies on substance use and addiction, encouraging innovative analysis without the need for new data collection.

Health
State governments
FY 2024 Notice of Funding Opportunity for Small Shipyard Grants
$1,000,000
DOT-MA (Maritime Administration)
Federal

Application Deadline

May 8, 2024

Date Added

Mar 27, 2024

This notice announces the intention of the Maritime Administration to provide grants to small shipyards. Under the Small Shipyard Grant Program, there is currently $8,750,000 available for grants for capital and related improvements to qualified shipyard facilities that will be effective in fostering efficiency, competitive operations, and quality ship construction, repair, and reconfiguration. Potential applicants are advised that it is expected, based on experience, that the number of applications will far exceed the funds available and that only a small percentage of applicants will be funded. Applications (SF-424 and the Addendum) will be accepted online through Grants.gov by 5 pm on the closing date (May 8, 2024). See full text under Related Documents Tab (FY 2024 SSG NOFO) or the MARAD Web Page (https://www.maritime.dot.gov/grants-finances/small-shipyard-grants) for detailed submission instructions

Transportation
Small businesses
Alzheimer's Disease Research Centers (P30 Clinical Trial Not Allowed)
$2,925,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Sep 26, 2025

Date Added

Jan 11, 2023

This funding opportunity provides financial support to higher education institutions and nonprofits to establish or renew research centers focused on advancing studies related to Alzheimer's disease and related dementias, promoting collaboration, innovation, and diversity in research efforts.

Health
State governments
BRAIN Initiative: Research on the Ethical Implications of Advancements in Neurotechnology and Brain Science (R21 Clinical Trial Optional)
$200,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Oct 10, 2025

Date Added

Feb 16, 2024

This funding opportunity supports short-term research projects that explore the ethical challenges arising from advancements in neurotechnology and brain science, encouraging collaboration between ethicists and neuroscientists.

Health
State governments
FY25 NOAA Marine Debris Interception Technologies under the Bipartisan Infrastructure Law
$1,000,000
U.S. Department of Commerce (DOC NOAA - ERA Production)
Federal

Application Deadline

Feb 7, 2025

Date Added

Jul 26, 2024

This funding opportunity provides financial support for projects that install and maintain technologies to intercept and remove marine debris, benefiting coastal habitats and marine resources.

Environment
State governments
Exponentiating Mathematics (expMath)
Contact for amount
U.S. Department of Defense (DARPA - Information Innovation Office)
Federal

Application Deadline

Jul 15, 2025

Date Added

May 14, 2025

This funding opportunity seeks innovative research proposals from universities, businesses, and nonprofits to develop advanced AI technologies that can significantly accelerate mathematical progress and enhance national competitiveness.

Science and Technology
City or township governments
Closing inequities in HIV Prevention, Care and Treatment among key populations in Togo Activity (Equity KP Togo)
$5,000,000
U.S. Agency for International Development (West Africa U.S.AID-Ghana)
Federal

Application Deadline

Oct 13, 2024

Date Added

Aug 22, 2024

The "Closing inequities in HIV Prevention, Care and Treatment among key populations in Togo Activity (Equity KP Togo)" grant aims to support local entities in Togo and Burkina Faso in providing quality HIV services, improving the environment for key populations and their partners, and enhancing monitoring and sustainability efforts for HIV epidemic control by 2030.

Health
Individuals