Grants for Special district governments - Federal

The Red Bluff Fish and Wildlife Office (RBFWO), Central Valley Project Improvement Act (CVPIA) Program is soliciting proposals for the completion of a Feasibility Study to assess potential solutions to increase available floodplain habitat in the lower Feather River corridor through Nelson Slough and contribute to improved quality of juvenile salmonid rearing habitat through increased production and availability of food resources. The project location is in the California Department of Fish and Wildlifes Feather River Wildlife Area Nelson Slough Unit. Scope of WorkThis award will provide funds for a work effort consisting of identification, development and feasibility of a floodplain connectivity solution in Nelson Slough primarily benefiting juvenile salmonids. This will include facilitating meetings with the Technical Advisory Committee, composing of members from United States Fish and Wildlife Service (USFWS), National Marine Fisheries Service, California Department of Fish and Wildlife (CDFW) and California Department of Water Resources (CDWR). The USFWS and Project Management Team intend to use information collected from this study to develop a future habitat restoration project at this site. The project tasks and applicant responsibilities are the following: Information gathering and site reconnaissance; Project Management;Data Collection and Evaluation; Develop a multi-dimensional hydrodynamic flow model to assess floodplain inundation frequencies; Develop a sediment transport model; Landowner access; Facilitate, plan, and provide notes from Technical Advisory Committee meetings; andDevelop juvenile salmonid habitat alternatives (i.e., restoring natural processes, side-channel creation through historic oxbow, floodplain connectivity, etc.).Project The CVPIA SIT and Core Team recommended increasing access to juvenile rearing habitat in lower Feather River and Sutter Bypass and identified it as a high priority for FY2020 (2019 Tech Memo). The project will continue to be funded for planning and analysis in FY2025 with potential construction and implementation in FY2026. The proposed project completes a feasibility study to develop and evaluate potential restoration actions at the Nelson Slough Wildlife Area Unit to increase the frequency with which floodplain habitat is inundated. The project would be located on CDFW property at the confluence of the lower Feather River corridor and the Sutter Bypass near Nelson Slough.The project may include lowering and widening an existing slough within setback levees in the lower Feather River corridor downstream of Highway 99 and tying this into the Sutter Bypass; creating multiple swales within the area; and/or lowering the floodplain terrace. This would allow Feather River basin water to flow into the Sutter Bypass with much greater frequency than under current conditions, thereby connecting remnant floodplain (including an abandoned oxbow from the Feather River) in the lower Feather River corridor with existing floodplain in the Sutter Bypass. Nelson Slough, a 750-acre unit of the Feather River Wildlife Area, is adjacent to more than 3,500 acres of conservation properties along the Feather River and approximately 4,500 acres of conservation properties within the Sutter Bypass. The project could increase floodplain habitat available to Feather, Yuba, and Bear River salmonids by up to 1,000 acres or more under certain flow conditions. Additional floodplain inundation resulting from this project could provide rearing benefits to Sacramento River origin juvenile winter and spring-run Chinook salmon, juvenile Butte Creek spring-run Chinook salmon in the Sutter Bypass, Feather River basin spring-run Chinook salmon, as well as Central Valley steelhead and potentially juvenile green sturgeon. Currently, River Partners has been awarded funds through the CVPIA for improving salmon and steelhead juvenile rearing habitat through creation and restoration of up to five miles of side channels on the Lower Feather River adjacent to the Nelson Slough Wildlife Area Unit. This project could potentially be integrated with the River Partners Lower Feather River Side Channel Restoration Project. The Peterson, Coarse Resolution model Report, 2014 (DSM) suggests that supporting increasing juvenile Chinook size at emigration can be beneficial to the outcome of a greater number of returning adults. Post project monitoring may help improve or validate the hypothesis of the DSM. Supplemental InformationOutcome of the project would achieve the following goals: Increase accessible floodplain for Feather, Yuba, and Bear River salmonids by through increased access; Determination of the amount of accessible acres created at various flow ranges compared to existing conditions with various landscape changes;Reduce habitat fragmentation to improve rearing and emigration corridors; Increase and improve the quantity, quality, and diversity of riverine habitat, including floodplain rearing habitat for juvenile fish; Reduce predation impacts of non-native fish species in channel;Increase native riparian vegetation in restored habitat;Contribute to the recovery of federal and state listed fish populations; and Contribute to the Central Valley Project Improvement Act doubling goal for the Feather, Yuba, and Bear Rivers. Questions that will be addressed in the feasibility study are:Up-to-date topographic and bathymetric LiDAR or similar, relative to project area or any other areas of influence. Characterization of the hydrodynamics that would facilitate floodplain activation. Characterization of the hydrodynamics that would facilitate floodplain activation. Prioritize updating physical habitat characterization.Focus on (potential) instream system parameters (longitudinal profiles, cross section installation and revisiting those, etc.). Using a drone to map area pre-project, as well as post project. Assess:Flood conveyance, flood storage and inundation frequency and duration; Fluvial geomorphic processes;Aquatic and riparian habitat;Project costs;Land availability;Sedimentation;Excavated materials and spoil placements; andInfrastructure (i.e. utility pipelines, roadway bridge abutments).Pre-project assessments: This would include assessing hydrology and water quality, as well as biologic monitoring cataloging insect, bird, and other current animal habitat necessary to understand what the area is currently providing and serve as a baseline for assessing post project performance after implementation. Monitoring and evaluation are essential to determine whether restoration projects are implemented correctly and performing as expected so that we achieve the intended benefits. Wildlife Habitat Area Management Objectives: Current acreage of upland habitat shall not be decreased. Must not fragment current available upland habitat.Any side channels created would require a crossing for wildlife and staff to facilitate bird plants. Species of interest include quail, deer, turkey, pheasant, and multiple waterfowl. No restoration activity shall reduce the various hunting opportunities offered by CDFW on the Nelson Slough Unit (i.e., deer hunt season, waterfowl hunt season, quail hunt season, turkey fall hunt season, turkey spring hunt season, and pheasant hunt season). Awardee will coordinate closely with CDFW wildlife area staff to develop alternatives that do not impact these opportunities for the public. Considerations:Consider restoration design and implementation timing with DWR and Sutter County to complement their future levee improvement work at the Nelson Slough Unit and the surrounding reach of the Feather River and Sutter Bypass as described in the Riparian Restoration Plan for the Nelson Slough Unit (2009 River Partners) Department PriortiesThe mission of the U.S. Fish and Wildlife Service is working with others to conserve, protect, and enhance fish, wildlife, plants, and their habitats for the continuing benefit of the American people. Fish and Aquatic Conservation is an integral program within the U.S. Fish and Wildlife Service and supports the mission by working with partners to achieve benefits for aquatic species and their habitats. The U.S. Fish and Wildlife Service plays a key role in addressing the challenges identified in the Biden-Harris administrations priorities. https://www.fws.gov/initiative/directors-priorities Rebuilding the economy;Tackling climate change;Developing a wildlife conservation strategy for the 21st century;Combating Wildlife Trafficking.

This funding opportunity provides financial support to small rural hospitals and health clinics to help them improve their healthcare services and transition to a value-based care system for better patient outcomes.

This notice of funding opportuntity (NOFO) encourages applications for investigator-initiated multi site clinical trials (e.g., efficacy, effectiveness, or pragmatic trials) to study the effects of complementary and integrative health approaches with physical and/or psychological therapeutic inputs (often called mind and body interventions), and/or multicomponent interventions that include physical, psychological, and/or nutritional approaches in NCCIH- designated areas of high research priority. Clinical Coordinating Centers (CCC) should develop and implement the proposed fully powered multi-site clinical trial (Phase III and beyond). The objective of a CCC application is to present the scientific rationale and a comprehensive scientific and operational plan for the clinical trial. CCCapplications are expected to describe plans for project management, participant recruitment and retention strategies, performance milestones, scientific conduct, and dissemination of results. CCC applications submitted under this NOFO will utilize a two-phase, milestone-driven cooperative agreement (UG3/UH3) funding mechanism. In addition, an accompanying Data Coordinating Center (DCC) application (U24), submitted under PAR-24-087 proposing a data analysis and data management plan for the clinical project is required. Both a CCC application and a corresponding DCC application need to be submitted simultaneously for consideration by NCCIH. For additional information about the mission, strategic vision, and research priorities of NCCIH, applicants are encouraged to consult the NCCIH website: (https://nccih.nih.gov/about/plans). Applicants are encouraged to contact the appropriate Scientific/Research contact for the area of science for which they are planning to develop an application prior to submitting to this NOFO.

This funding opportunity provides financial support to early-career researchers in the fields of arthritis, musculoskeletal, and skin diseases, helping them conduct small-scale studies as they transition to independent investigator roles.

The "Addressing the Impact of Structural Racism and Discrimination on Minority Health and Health Disparities" grant aims to fund research projects that explore and address the effects of structural racism and discrimination on the health of minority and disadvantaged groups, with the goal of improving health outcomes and promoting health equity.

This funding opportunity provides financial support to early-career researchers in the dental and craniofacial fields to conduct pilot studies that will help them secure larger research grants in the future.

(Reissue of PAR-18-486) The purpose of the NINDS Faculty Development Award to Promote Diversity in Neuroscience Research (K01) is to diversify the pool of independent neuroscience research investigators by providing junior faculty with research cost support, protected research time and career stage appropriate professional development mentorship in neuroscience research. Individuals from backgrounds underrepresented in biomedical research are eligible for support under this award if they have doctoral research degrees (Ph.D. or equivalent) and are in the first 3 years of a faculty tenure track or equivalent position at the time of application. This Funding Opportunity Announcement (FOA) is designed specifically for applicants proposing to serve as the lead investigator of an independent clinical trial, a clinical trial feasibility study, or a separate ancillary study to an existing trial, as part of their research and career development. NINDS will only accept applications to this FOA that propose human mechanistic trials/studies that meet NIH's definition of a clinical trial and that fall within the NINDS research priorities. Applicants are strongly advised to consult with NINDS program staff prior to submitting an application with human subjects to determine the appropriate funding opportunity.

The purpose of this Notice of Funding Opportunity Announcement (NOFO) is to solicit applications for the Coordinating Center (CC) of the ML/AI Tools to Advance Genomic Translational Research (MAGen) Consortium. In collaboration with the MAGen Sites funded by the companion NOFO (RFA-HG-24-004) the CC will explore the feasibility of developing Machine Learning (ML) and Artificial Intelligence (AI) tools that can enhance the accuracy and precision of predicting how individuals with pathogenic genetic variants manifest disease. The CC will be responsible for implementing approaches to bring diverse teams together to enable synergistic and collaborative team science across the Consortium. Specifically, the CC will be responsible for technical, scientific, and administrative coordination activities to support the Consortium research activities including development of consortium wide plans, coordinated ELSI-informed ML/AI tool development and cross validation, and dissemination of the developed resources.

Substance use needs to be better incorporated into interventions for the engagement and retention of sexual minority persons in prevention and care with attention to emergent interventions such as long-acting PrEP. Social determinants of health associated with HIV and problematic substance use such as homelessness and criminal justice involvement also demonstrate disproportionate impact among sexual and gender minorities and need attention. Changing self-definition of sexual minority status has implications for outreach and provider stigma and needs to be better integrated into interventions. This initiative will address these gap areas and support epidemiologic, intervention, and implementation research that incorporates attention to HIV as a syndemic including comorbidities such as STIs, HCV, and psychiatric disorder.

This funding opportunity provides financial support to a variety of organizations, including local governments and nonprofits, to strengthen the capacity of regional authorities in Tanzania to effectively manage and deliver comprehensive HIV and tuberculosis prevention, care, and treatment services.

This funding opportunity supports researchers in analyzing and integrating existing data to better understand cancer risks and outcomes, ultimately advancing cancer research and treatment strategies.

This funding opportunity provides financial support to water and power authorities, as well as nonprofit conservation organizations in the western U.S., to implement projects that enhance water efficiency, promote renewable energy, and improve sustainability in response to water scarcity and climate challenges.

The United States Department of the Interior (Department), Bureau of Reclamations (Reclamation) Desalination and Water Purification Research Program (DWPR) works with Reclamation researchers and partners to develop innovative, cost-effective, and technologically efficient ways to desalinate and treat water. DWPR funding plays a critical role in iterating an idea from the lab to a real-world demonstration, yielding products that serve the water treatment community and attract commercialization interest. Reclamation is interested in research where the benefits are widespread but where private-sector entities are not able to make the full investment and assume all the risks. Reclamation is also interested in research that has a national significancewhere the issues are of large-scale concern and the benefits accrue to a large sector of the public. The goal of the DWPR program is to address the need to reduce the costs, energy requirements, and environmental impacts of treating impaired and unusable water. The program also aligns with Executive Order 14008, Tackling the Climate Crisis at Home and Abroad, by investing in development and application of advanced water treatment technologies that expand access to otherwise unusable water resources, thereby increasing water supply flexibility under the risks of long-term climate change and shorter-term drought. For further information on the DWPR Program, see www.usbr.gov/research/dwpr.

This grant provides funding for a Data Coordinating Center to support research projects focused on preventing stillbirth, emphasizing collaboration and equity in addressing disparities in vulnerable populations.

The "Research on Autism Spectrum Disorders" grant aims to fund projects that explore the causes, prevalence, diagnosis, and best service delivery methods for Autism Spectrum Disorders, with a focus on small, well-defined projects that can be completed within two years using limited resources.

The National Institutes of Health (NIH) hereby notify recipient organizations holding specific types of NIH grants, listed in the full Funding Opportunity Announcement (FOA), that applications for change of recipient organization may be submitted to this FOA. This assumes such a change is programmatically permitted for the particular grant. Applications for change of recipient organization are considered prior approval requests (as described in Section 8.1.2.7 of the NIH Grants Policy Statement) and will be routed for consideration directly to the Grants Management Specialist named in the current award. Although requests for change of recipient organization may be submitted through this FOA, there is no guarantee that an award will be transferred to the new organization. All applicants are encouraged to discuss potential requests with the awarding IC before submission.

The purpose of this Notice of Funding Opportunity (NOFO) is to support the development of clinical research platforms that will enable future clinical trials to determine whether combinations of HIV cure strategies can be effective when optimally tailored to the participants. The ultimate goal is for the results of such proof-of-concept clinical studies to inform the development and prioritization of more broad-based curative strategies that will be effective in all people living with HIV. This NOFO will support multidisciplinary teams to conduct coordinated basic and pre-clinical research to profile participants intact, rebound-competent HIV reservoirs and immunologic backgrounds and use that information to develop and test combinations of HIV curative approaches that are specifically tailored to those participants.

Modified release (MR) oral drug products are considered to have a high risk for alcohol dose dumping (ADD) because they contain large quantities of drug(s), designed to release over a prolonged period of time. Accidental exposure of these products to alcohol can result in the relatively rapid release of large quantities of drug with severe side effects, including death. To mitigate this risk, the FDA recommends conducting an in vitro alcohol dose dumping assessment in 0%, 5%, 20%, and 40% alcoholic dissolution media for all prospective generic versions of MR oral drug products. To date, ADD assessments have not been harmonized globally. For instance, the U.S. FDA recommends testing up to 40% alcoholic media while the European Medicines Agency recommends testing up to 20% alcoholic media. This type of difference can present a challenge for formulators designing products for multiple markets, as historical data has shown release from MR oral products do not always follow a linear response (either increasing or decreasing) to increasing alcohol concentrations. In addition, interpretation of an ADD assessment may be limited by the inability of the test to predict in vivo behavior. The purpose of this research is to develop tools that 1) facilitate the development of MR generic drug products that have a low potential for ADD, 2) support regulatory decision making during the assessment of such products, and 3) provide evidence that enables FDA to develop more specific recommendations for efficiently demonstrating a low or comparative potential of alcohol dose dumping for MR oral drug products containing high risk drugs.

This funding opportunity supports small-scale brain imaging research related to substance use and addiction, aimed at helping both new and established researchers develop innovative studies that enhance our understanding of neurobiological mechanisms in these areas.

This funding opportunity supports research teams from various sectors to explore how sex differences influence the biological factors related to Alzheimer’s disease and its treatment, aiming to enhance understanding and improve precision medicine approaches.