Federal Health Grants

This funding opportunity supports innovative research to develop combination cancer therapies that integrate radiation treatment with targeted molecular agents, aimed at improving treatment effectiveness while reducing side effects.

This funding opportunity supports the establishment of Clinical Coordinating Centers for multi-site clinical trials focused on heart, lung, and blood health issues, encouraging collaboration and community engagement to improve trial efficiency and address health disparities.

The purpose of this Negotiation Cooperative Agreement is to provide Tribes with resources to help defray the costs associated with preparing for and engaging in TSGP negotiations. TSGP negotiations are a dynamic, evolving, and tribally driven process that requires careful planning, preparation, and sharing of precise, up-to-date information by both Tribal and Federal parties. Because each Tribal situation is unique, a Tribes successful transition into the TSGP, or expansion of their current program, requires focused discussions between the Federal and Tribal negotiation teams about the Tribes specific health care concerns and plans. One of the hallmarks of the TSGP is the collaborative nature of the negotiations process, which is designed to: 1) enable a Tribe to set its own priorities when assuming responsibility for IHS PSFAs; 2) observe and respect the government-to-government relationship between the U.S. and each Tribe; and 3) involve the active participation of both Tribal and IHS representatives, including the OTSG. Negotiations are a method of determining and agreeing upon the terms and provisions of a Tribes Compact and FA, the implementation documents required for the Tribe to enter into the TSGP. The Compact sets forth the general terms of the government-to-government relationship between the Tribe and the Secretary of the U.S. Department of Health and Human Services (HHS). The FA: 1) describes the length of the agreement (whether it will be annual or multi-year); 2) identifies the PSFAs, or portions thereof, the Tribe will assume; 3) specifies the amount of funding associated with the Tribal assumption; and 4) includes terms required by Federal statutes and other terms agreed to by the parties. Both documents are required to participate in the TSGP and they are mutually negotiated agreements that become legally binding and mutually enforceable after both parties sign the documents. Either document can be renegotiated at the request of the Tribe.

The purpose of this Notice of Funding Opportunity (NOFO) is to support formative research and pilot testing of culturally sensitive, innovative interventions to identify and mitigate the risk of suicidal ideation and behavior (SIB), and/or non-suicidal self-injury (NSSI) in Low- and Middle-Income Countries (LMICs). The proposed research initiatives must incorporate a plan to strengthen research capacity within the LMIC community where the study will be conducted.

This funding opportunity supports the Coriell Institute in maintaining and expanding a repository of high-quality human cell lines and DNA samples for biomedical research, benefiting scientists studying genetic disorders and human health.

This grant provides funding for researchers, especially those new to the field or looking to integrate advanced data science methods, to explore addiction-related questions using existing data and innovative analytical techniques.

This funding opportunity supports U.S.-based researchers and organizations in developing non-addictive pain relief therapies to combat the opioid crisis, with a focus on advancing preclinical candidates toward clinical trials.

Enhances the integration of HIV-related services and primary healthcare in select countries that are at or near HIV epidemic control to sustain gains made by PEPFAR and contribute to resilient public health systems. The United States President's Emergency Plan for AIDS Relief (PEPFAR) is a US governmental initiative to address the global HIV/AIDS epidemic. To ensure longevity and sustainability in areas with low HIV prevalence, HIV treatment can be incorporated into existing successful primary health care models with decentralised service delivery to promote adherence to long-term treatment.18 With support from the United States Agency for International Development (USAID) and other international partners, Haiti has had integrated HIV and primary health-care services for over 20 years.19, 20 The PEPFAR programme in Haiti integrates HIV, maternal and child health care, and family planning services in primary health-care settings to reduce HIV stigma. At the site level, Haitians who receive maternal and child health care and family planning services also obtain HIV education and screening, as well as STI education and treatment. At the community level, Haiti provides integrated HIV self-testing, postnatal visits, immunisations, referral services, adherence counselling, and tracking of treatment interruptions. HIV services are also being integrated into the scope of work for community health workers.21 Efforts to make HIV treatment more sustainable include gradual transition of donor-paid health worker salaries to the national budget.

The FY 2024 Strategic Prevention Framework-Partnerships for Success (SPF-PFS) for States funding opportunity, managed by SAMHSA’s Center for Substance Abuse Prevention, is designed to assist states in building prevention capacities to reduce substance misuse and related behavioral health issues. This program specifically targets communities facing high risks of substance misuse by supporting the development and delivery of evidence-based, data-driven prevention services at the state and community levels. By leveraging the Strategic Prevention Framework (SPF), this initiative prioritizes underage drinking, opioid misuse, and other substance use concerns. The funding emphasizes the involvement of underserved communities, which includes racial, ethnic, and geographic groups systematically denied access to necessary resources and services. Eligible applicants are U.S. states, territories, Pacific jurisdictions, and the District of Columbia. The funding opportunity is not open to entities that have previously received SPF-PFS funds under specific past awards to avoid redundancy in funding. For FY 2024, SAMHSA will distribute a total of $15.5 million across approximately 12 awards, with each award offering up to $1.25 million annually over a five-year period, contingent on available appropriations. Applications are due by February 21, 2024, with anticipated project start dates of September 30, 2024. Required activities include assessing community needs, building partnerships, collecting and analyzing data, and implementing community-level health assessments. States are expected to create a statewide community health improvement plan that aligns with prevention priorities identified through these assessments. At least 60% of each award must be directed to subrecipient communities that demonstrate a need for programming in chosen priority areas. The SPF process involves five main steps—assessment, capacity building, planning, implementation, and evaluation—plus guiding principles of cultural competence and sustainability. States must ensure coordination with other community-based recipients of SPF-PFS funding and leverage partnerships with the Prevention Technology Transfer Center for technical support. Applications must include a project narrative limited to 10 pages, detailing the project’s goals, objectives, required activities, and a budget justification. SAMHSA requires a dedicated Project Director and Data Analyst with specific time commitments. A letter to the Single State Agency, confidentiality protocols, and biographical sketches are also required. Bonus points are available for applicants demonstrating a focus on underserved populations, making up at least 50% of the population served. Data collection will follow the Government Performance and Results Modernization Act, with performance data submitted quarterly via SAMHSA’s reporting system (SPARS). Evaluation criteria for the grant include feasibility, organizational capacity, project alignment with program goals, cost-effectiveness, and commitment to behavioral health equity. Applicants must provide documentation of their efforts to identify and address health disparities in the populations served. Grant recipients must report on performance quarterly and annually, including progress in underserved communities and efforts to reduce behavioral health disparities.

This funding opportunity supports researchers developing and testing strategies to prevent fetal alcohol spectrum disorders and improve interventions for affected individuals throughout their lives.

This funding opportunity supports research projects that explore how patients' beliefs and expectations about cancer treatment can improve symptom management, particularly for underserved populations facing unique challenges in care.

The "Research Experiences to Enhance Clinician-Scientists' Participation in NIDCDs Research" grant aims to support educational activities and hands-on research experiences that encourage clinicians, particularly those from diverse backgrounds, to pursue research careers in biomedical, behavioral, and clinical sciences, with a focus on areas relevant to the National Institute on Deafness and Other Communication Disorders (NIDCD).

This funding opportunity provides financial support to various organizations, including health centers and nonprofits, to implement evidence-based strategies that increase colorectal cancer screening rates among underserved populations aged 45 to 75.

This program provides financial assistance to state and local agencies, victim service organizations, and non-profits to support victims of terrorism and mass violence through compensation and crisis response services.

This funding opportunity supports researchers in developing and optimizing neurophysiological measures to improve the treatment development process for mental disorders in both humans and relevant animal species.

The "NCI National Clinical Trials Network - Network Lead Academic Participating Sites" grant is a funding opportunity from the National Cancer Institute for academic centers to provide scientific leadership and patient recruitment for large-scale, multi-institutional cancer clinical trials, with a focus on treatment trials, rare cancers, and underserved populations, offering up to $1.7 million per year for a six-year project period.

This grant provides preclinical support services to researchers developing innovative HIV therapies and addressing related health issues, enabling them to advance their drug development efforts.

This grant provides funding for researchers to conduct early-stage clinical trials aimed at improving treatments for patients with arthritis, musculoskeletal, or skin diseases.

This funding opportunity provides financial support to American Indian and Alaska Native tribes and organizations to enhance substance use prevention and behavioral health services in their communities.

This funding opportunity provides financial support for researchers and institutions to develop and optimize animal models that assess brain circuit engagement, aiming to improve therapeutic approaches for mental health conditions.