Federal Health Grants

The NINDSintends to reissuePAR-23-027 to solicit applications for basic research projects on chemical warfare agents, toxic industrial chemicals, and pesticides that have primary or secondary effects on the nervous system. Chemical threats are toxic compounds that could be used in a terrorist attack or accidentally released from industrial production, storage, or shipping. Projects supported by this NOFO are expected to generate data that elucidate mechanisms of toxicity of these agents, possible new manifestations of toxic exposures, and potential new targets for therapeutic development. This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. The NOFO is expected to be published in Winter 2024 with an expected application due date in Spring 2024. This NOFO will utilize the R01 activity code. Details of the planned NOFO are provided below.

The purpose of this Funding Opportunity Announcement (FOA) is to solicit applications for the Research Units (RUs), one of the two scientific components of the Pancreatic Cancer Detection Consortium (PCDC), to conduct research on early detection of pancreatic ductal adenocarcinoma (PDAC) and characterization of its precursor lesions to identify those patients who are at high risk of progression to cancer. The PCDC will continue to address one of the four research priorities identified in the National Cancer Institute's 2014 Scientific Framework for Pancreatic Ductal Adenocarcinoma. The PCDC will support research for the development and testing of new molecular and imaging biomarkers for detecting PDAC early and for identifying those patients at high risk of PDAC (because of genetic factors or presence of precursor lesions) who could be candidates for early intervention. The PCDC-RUs will consist of multi-disciplinary teams and will undertake studies to: identify and test biomarkers measurable in bodily fluids for early detection of PDAC and/or its precursor lesions; determine which pancreatic cysts are likely to progress to cancer; develop molecular- and/or imaging-based approaches for screening populations at high risk of PDAC; use machine learning and computational approaches towards biomarker discovery and/or validation; and conduct biomarker validation studies. The PCDC-RUs will also collect longitudinal biospecimens for building a biorepository. Each PCDC-RU is expected to participate in collaborative activities with other PCDC-RUs and share ideas, biospecimens and data within the Consortium. The other scientific component of the PCDC will be the Management and Data Coordination Unit (MDCU). The PCDC-MDCU will provide support toward study design, protocol development, statistical analysis, coordination, harmonization, data management and stewardship for the trans-PCDC collaborative projects, including biorepository building effort.

This funding opportunity supports U.S. higher education institutions with doctoral programs in health professions to enhance their research capabilities and address health disparities through collaborative research projects.

This funding opportunity provides financial support to small U.S.-based businesses for the development and validation of analytical methods to measure biomarkers related to neurological and neuromuscular disorders, with an emphasis on enhancing inclusivity and collaboration in research.

This funding opportunity supports innovative research to improve personalized probiotic treatments by studying individual biological factors that influence how people respond to probiotics.

This funding opportunity supports innovative research projects aimed at improving workplace safety and health by addressing significant occupational hazards in various organizations across the United States.

This funding opportunity supports the establishment of a 24-hour hotline to provide crisis intervention and resources for Indigenous victims and survivors of family violence, ensuring they receive culturally relevant and accessible services.

This grant provides funding for innovative research projects that explore the effects of HIV/AIDS on communication disorders and develop strategies to improve the quality of life for individuals living with HIV.

This funding opportunity provides financial and technical support to federally recognized Indian Tribes and Tribal Organizations to strengthen their health management capabilities and improve service delivery under the Indian Self-Determination and Education Assistance Act.

The purpose of this Notice is to alert the community that the National Institute of Neurological Disorders and Stroke (NINDS) plans to reissue initiativeRFA-NS-21-033 Materials to Enhance Training in Experimental Rigor (METER) with one receipt date. The program is designed to support the compilation and refinement of educational materials that will be incorporated into a new cutting-edge online resource that aims to promote awareness, understanding, and practice of fundamental principles of rigorous biomedical research for scientists in various career stages and learning environments. Awardees will collaborate with the established coordinating center, which is funded by the companionRFA-NS-21-009 Creating an Educational Nexus for Training in Experimental Rigor (CENTER). This coordinating center (CENTER) is responsible for organizing the initiative, building the final web-based platform, harmonizing the educational units, and producing digital elements (e.g., videos, graphics, interactive components) that are beyond the technical capabilities of METER awardees. This collaboration between CENTER and METER awardees will include activities to improve, finalize, evaluate, and disseminate the resulting educational units drafted by METER awardees. More information about the initiative, its current progress, and frequently asked questions can be found at https://www.ninds.nih.gov/current-research/trans-agency-activities/rigor-transparency/initiative-improve-education-principles-rigorous-research. This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. The overall objectives of the program have not changed; however, potential applicants can expect minor changes to improve the clarity of the previous announcement. The NOFO is expected to be published in Summer 2024 with an expected application due date in October 2024. This NOFO will utilize the UE5 activity code. Details of the planned NOFO are provided below.

This funding opportunity supports researchers in developing new medications to prevent and treat opioid and stimulant use disorders and overdose, with a focus on advancing promising treatments towards FDA approval.

This funding opportunity provides financial support to nonprofit organizations and government entities to improve access to meal programs for older adults with behavioral health conditions, including those experiencing homelessness, across the state.

This funding opportunity supports innovative research using microbes to improve cancer diagnosis and treatment, targeting researchers and institutions focused on microbiology, oncology, and immunology.

This notice of funding opportunity (NOFO), utilizing the U24 grant funding mechanism, encourages applications for a collaborating Data Coordinating Center (DCC) application that accompanies an investigator-initiated multi site clinical trial (Phase III and beyond) application submitted under companion PAR-21-243. The DCC application must be specific to the companion Clinical Coordinating Center (CCC) application. The objective of the DCC application is to propose a comprehensive plan that provides overall project coordination, and administrative, data management, and biostatistical support for the proposed clinical trial. Both a DCC application and a corresponding CCC application need to be submitted simultaneously for consideration by NCCIH. Trials for which this NOFO applies must be relevant to the research mission of NCCIH and considered a high priority by the Center. For additional information about the mission, strategic vision, and research priorities of NCCIH, applicants are encouraged to consult the NCCIH website (http://www.nccih.nih.gov). Applicants are encouraged to contact the appropriate Scientific/Research contact for the area of science for which they are planning to develop an application prior to submitting to this NOFO. This NOFO requires a Plan for Enhancing Diverse Perspectives (PEDP), which will be assessed as part of the scientific and technical peer review evaluation. Applications that fail to include a PEDP will be considered incomplete and will be withdrawn.Applicants are strongly encouraged to read the NOFO instructions carefully and view the available PEDP guidance material.

This funding opportunity supports innovative research projects that explore how sex hormones affect the relationship between HIV and substance use disorders, targeting scientists and institutions focused on molecular biology and addiction.

This funding opportunity supports researchers in developing innovative informatics methods and algorithms to improve cancer research and management across various areas, including diagnosis, treatment, and prevention.

This funding opportunity supports researchers in analyzing existing data to better understand the developmental patterns and risk factors associated with late talking in children, while promoting data sharing and inclusivity in research.

The Second Chance Act (SCA) of 2007 (Public Law 110- 199), reauthorized by the First Step Act of 2018, provides a comprehensive response to assist in the transition individuals make from adult confinement facilities (e.g., jails, prisons, detention centers) to their communities so that the transition is successful and promotes public safety. With this solicitation, BJA seeks to fund up to one award to deliver training and technical assistance (TTA) to correctional institutions to improve justice and health outcomes for reentering individuals by leveraging financing mechanisms, including new and existing Medicaid and CHIP opportunities.

This Notice of Funding Opportunity (NOFO) invites applications from eligible small businesses to develop solutions for commercialization that can be used to enable regional clinician-to-clinician genomic medicine eConsult services. Specifically, we seek products, such as technologies or services, that will allow for the development and sustainment of eConsult services. Eligible United States small business concerns (SBCs) may submit Small Business Technology Transfer (STTR) Phase I, and Fast-Track grant applications. Small business applicants interested in submitting a Small Business Innovation Research (SBIR) grant application should submit to the related funding opportunity, PAR-24-106. SBIR and STTR are phased programs. The main objective in SBIR and STTR Phase I is to establish the technical merit and feasibility of the proposed research and development efforts. An SBIR and STTR Phase II continues the R&D efforts to advance the technology toward ultimate commercialization. At the conclusion of an SBIR/STTR Phase II, it is expected that the small business will fully commercialize their product or technology using non-SBIR/STTR funds (either federal or non-federal). Small businesses that are eligible to submit Phase II applications for projects that were supported with a Phase I SBIR or STTR award are expected to submit the regular Phase II application as a "Renewal" application based on the awarded Phase I SBIR or STTR project. Only one Phase II application may be awarded for a specific project supported by a Phase I award.

The National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention (CDC), invites grant applications for Education and Research Centers (ERCs) that are focused on occupational safety and health training. NIOSH is mandated to provide an adequate supply of qualified personnel to carry out the purposes of the Occupational Safety and Health Act, and the ERCs are one of the principal means for meeting this mandate. ERCs are academic institutions that provide high-quality interdisciplinary graduate and post-graduate training, research training, continuing education, and outreach in the core occupational safety and health disciplines of industrial hygiene, occupational health nursing, occupational medicine, and occupational safety, as well as allied disciplines. Research and research training are integral components of ERCs, with ERC faculty and NIOSH trainees conducting research on issues related to the NIOSH National Occupational Research Agenda (NORA) and emerging issues to advance the field of occupational safety and health. NIOSH ERCs have regional presence to further diversify the occupational safety and health profession through their core values, mission statements and outputs. ERCs serve as resources for our nation's workforce through continuing education, outreach and strong collaboration with professional associations, worker advocacy groups, businesses, industries, and public health agencies. ERCs work with other institutions and organizations, including Minority Serving Institutions and other NIOSH supported training programs to have a positive impact on worker health, safety, and well-being.