Federal Health Grants

(Reissue of PAR-18-490) The purpose of the NINDS Faculty Development Award to Promote Diversity in Neuroscience Research (K01) is to diversify the pool of independent neuroscience research investigators by providing junior faculty with research cost support, protected research time and career stage appropriate professional development mentorship in neuroscience research. Individuals from backgrounds underrepresented in biomedical research are eligible for support under this award if they have doctoral research degrees (Ph.D. or equivalent) and are in the first 3 years of a faculty tenure track or equivalent position at the time of application. This Funding Opportunity Announcement (FOA) is designed specifically for applicants proposing research that does not involve leading an independent clinical trial, a clinical trial feasibility study, or an ancillary study to a clinical trial. Applicants to this FOA are permitted to propose research experience in a clinical trial led by a mentor or co-mentor.

This grant provides funding to establish state-based cooperatives that will improve behavioral healthcare for medically underserved populations by implementing patient-centered improvements based on evidence from patient-centered outcomes research.

This funding opportunity provides financial support for innovative research aimed at understanding the brain mechanisms behind substance use disorders, targeting a wide range of applicants including universities, nonprofits, and private organizations.

This funding opportunity supports small businesses in the U.S. to develop innovative technologies that improve health outcomes and reduce disparities for minority populations.

This funding opportunity announcement (FOA) invites research projects that seek to explain the underlying mechanisms, processes, and trajectories of social relationships and how these factors affect outcomes in human health, illness, recovery, and overall wellbeing. Types of projects submitted under this FOA include mechanistic studies that are classified as clinical trials. Mechanistic studies are defined as studies with the objective to understand the mechanism(s) of action of an intervention, a biological or behavioral process, or the pathophysiology of a disease/condition. See NOT-AT-20-001 and NOT-MH-19-006 for examples of clinical trials that are/are not considered mechanistic studies. Clinical trials that propose to influence a clinical outcome, test safety or feasibility of an intervention, demonstrate the clinical efficacy or effectiveness of an intervention, or analyze the effect size of an intervention on clinical outcomes are ineligible for this FOA. Types of studies that should submit under this FOA include clinical trials that assess biomedical or behavioral outcomes in humans for the purpose of understanding the fundamental aspects of phenomena without specific application towards processes or products in mind. Researchers proposing basic science experimental studies involving human participants should consider this FOAs companion for basic experimental studies with humans, TEMP-14931, Research on Health, Wellbeing, Illness, and Recovery (R01 Basic Experimental Studies with Humans Required). Applications proposing studies that include, but are not limited to, model animal research or observational studies involving humans should submit under the companion FOA, TEMP-14934, "Research on Biopsychosocial Factors of Social Connectedness and Isolation on Health, Wellbeing, Illness, and Recovery (R01 Clinical Trials Not Allowed).

This funding opportunity provides financial support to state, tribal, local, and territorial public health systems to enhance their preparedness and response capabilities for various public health emergencies.

Adolescence is a critical risk period for substance use initiation and adverse outcomes related to substance use, particularly as drug use has been found to escalate between ages 12 and 19. The goal of substance use prevention efforts is to prevent and/or delay the first use of substances. Research shows that early age of onset is an important predictor for the development of a substance use disorder later in life. Further, research shows that prevention interventions can have positive long-term effects in reducing substance use. Recognizing that preventing or delaying initiation of substance use can confer important health and social benefits, the purpose of the NCI is to serve as the training and technical assistance partner for DFC and non-DFC funded community coalitions across the country by enhancing the capacity of the prevention workforce and others in the prevention community to implement evidence-based interventions.

This grant provides funding for interdisciplinary research teams to develop innovative strategies for preventing and treating infections caused by antibiotic-resistant bacteria.

This funding opportunity supports research projects that combine imaging techniques and liquid biopsies to improve cancer treatment monitoring and response assessment in clinical settings.

This project seeks to further refine and geographically expand a methodology for obtaining drug early warning indicators through broader testing of urine samples that were previously collected and tested as part of an existing drug test protocol. This method was initially developed using local criminal justice populations including persons in pre-trial or lock-up, parolees or probationers, and drug court participants. A similar methodology is promising for use in other venues, such as in trauma units and emergency departments, where biological samples are often collected from patients. Before the specimens are discarded, the project will re-test them for an expanded panel of drugs, including xylazine, fentanyl, methamphetamine, and other new psychoactive substances (NPS); to determine what old and new illicit drugs are detected or missed by conventional testing protocols, and how the drug patterns might vary by subpopulation and geography. Bypassing the expense of collecting the original specimens and re-using those that have already been tested with known results yields a relatively inexpensive and timely picture of emerging drugs in a given subpopulation and locality. Hospital and de-identified nationally representative patient electronic health records (EHRs) should be collected and analyzed to put re-tested urine positivity results into a larger regional and national context of drug exposure and consequences. ONDCP is seeking to apply this testing methodology and insight from supplemental EHR investigations to emergency department and other hospital-system populations in locations throughout the United States to reinforce best practice guidelines, testing standardization, and build local and national surveillance capacity.

This funding opportunity supports early-stage research to develop new therapeutic agents for heart, lung, blood, and sleep disorders, specifically targeting projects that have identified promising small molecules or biologics ready for preclinical testing.

The Metastasis Research Network (MetNet) Research Projects grant aims to fund research projects that use comprehensive, systems-level approaches to address gaps in metastasis research, particularly focusing on themes like dormancy, early dissemination, and cellular or physical microenvironment interactions, with the goal of enhancing our understanding of metastasis as a whole-body, systems-level issue.

This program provides funding to communities across the U.S. to implement strategies that prevent and reduce alcohol use among youth and young adults aged 12 to 20.

This funding opportunity supports the establishment of research centers that leverage artificial intelligence and technology to advance studies in aging and Alzheimer's disease, inviting interdisciplinary teams from various organizations to innovate and train in this critical field.

The purpose of the NOFO is to establish and maintain a network of Regional Centers for Public Health Preparedness and Response to increase implementation of evidence-based strategies and interventions (EBSIs) and to improve public health preparedness and response, as informed by the needs of the communities involved. Support will be provided for up to ten centers to determine and support implementation of activities needed to increase use of EBSIs that will improve public health preparedness and response, as informed by the needs of the communities as described in regional workplans. The goal is to fund one center in each of the 10 HHS Regions. Each center will1) Coordinate relevant activities with applicable State, local, and Tribal health departments and officials, health care facilities, and health care coalitions to improve public health preparedness and response, as informed by the needs of the community, or communities involved.2) Develop and implement activities to support focus areas and objectives created by a regional coordinating body in 2023-24.3) As determined necessary by the CDC, and based on the availability of funding, support further implementation of evidence-based practices, or conduct research, evaluation, translation or dissemination necessary to address active or anticipated public health emergencies.4) One center will be awarded additional funds to support coordination and convening of centers and provide technical assistance and training as needed.

This funding opportunity supports innovative research projects that explore the intersection of HIV and substance use disorders, aiming to develop transformative strategies for prevention, treatment, and potential cures in affected populations.

This funding opportunity supports researchers developing innovative computational tools and methods to advance genomics, particularly those new to the field or from underrepresented groups.

This Notice of Funding Opportunity (NOFO) announces the opportunity to apply for funding under the Health Center Programs Service Area Competition (SAC). The purpose of this funding is to ensure continuity of care in the communities and populations currently served by the Health Center Program. See Program Requirements and Expectations for more details.

This funding opportunity provides financial support to community coalitions in the U.S. focused on preventing and reducing substance use among youth, particularly those aged 18 and under.

This funding opportunity provides financial support to institutions in low- and middle-income countries to enhance their capacity for managing research grants from the National Institute of Allergy and Infectious Diseases through advanced training and strategic development.