Grants for Small Businesses

This grant provides funding for large-scale, collaborative research projects that explore complex questions related to aging, requiring a multidisciplinary team and integration of various components across institutions.

The "CCRP Initiative: Countermeasures Against Chemical Threats (CounterACT) Therapeutics Discovery and Early-Stage Development" grant aims to fund the early-stage development of treatments to reduce the harmful health effects caused by exposure to toxic chemicals, which could be used in terrorist attacks or accidentally released from industrial sites, with the end goal of producing at least one well-characterized therapeutic candidate.

Microbes and communities of microbes have remarkable genetic, physiological and biochemical diversity, allowing them to flourish in environments all over the planet and in a variety of substrates and hosts. Given their relative importance to ecosystems around the world, to the economy and to health, researchers have studied microbial systems extensively and have a better understanding of their capabilities and impacts on hosts and the environment. In recent years, researchers have increasingly turned to microbes and their diverse capabilities for bioremediation and applications in biotechnology, agriculture, and medicine. Because of advances in molecular biology, synthetic biology and bioengineering, researchers now have the ability to assemble synthetic microbial communities that have novel compositions, genetics and phenotypes and to use these communities to address both fundamental biological questions and a range of societal problems. The goal of this solicitation is to support research that addresses one or more of the three themes: 1) define the underlying mechanisms or rules that drive the formation, maintenance or evolution of synthetic microbial communities, 2) use synthetic microbial communities to address fundamental biological questions, including questions in molecular biology, cellular/organismal biology, ecology and evolution and/or 3) build synthetic communities with biotechnology, bioeconomy or environmental engineering applications, including but not limited to the production of novel biorenewable chemicals, biodegradation of recalcitrant or forever chemicals, enabling a circular bioeconomy, fostering sustainable agriculture and mitigating the impacts of climate change. For theme 3, the emphasis should be on designing communities with novel capabilities and understanding the underlying mechanisms that lead to these novel capabilities. Proposals must address one or more of the three themes noted above. Highest funding priority is given to proposals that have outstanding intellectual merit and broader impacts, while proposals with weaknesses in either category (or those that are perceived as likely to have an incremental impact) will not be competitive. The most competitive broader impacts include assessment plans. Well-conceived broader impacts activities take time and resources; thus, proposers are encouraged to include appropriate costs for broader impacts in the budget. To better understand the societal benefits and risks, as well as the potential for misuse or unintended damage to natural biological systems, synthetic microbial communities proposals should include a careful consideration of the social, ethical, and biosafety/security dimensions of the research. Investigators may choose to address these issues either as part of intellectual merit or broader impacts. Reproducibility in research leads to data that is amenable to more powerful analysis and the potential for reuse of data and greater generation of knowledge. Reproducibility in biological research that is prone to context dependent biological variation presents a unique challenge for the synthetic microbial communities researchers. Investigators must follow or advance best practices in sample collection and preparation, experimental design, data analysis, model generation, and/or validation of mathematical and computational methods to produce scientifically defensible results.

This funding opportunity provides financial support for small businesses and researchers to develop innovative products and services aimed at preventing, diagnosing, and treating Alzheimer's disease and related dementias, ultimately improving care for affected individuals and their families.

This funding opportunity provides financial support for small businesses to develop innovative products and services aimed at preventing, diagnosing, and treating Alzheimer's disease and related dementias, ultimately improving care for affected individuals and their families.

This funding opportunity supports innovative research to develop combination cancer therapies that integrate radiation treatment with targeted molecular agents, aimed at improving treatment effectiveness while reducing side effects.

This funding opportunity supports research projects that explore innovative combinations of radiation therapy and other treatments to improve cancer care, inviting applications from a diverse range of organizations, including universities, nonprofits, and for-profit entities.

This grant provides funding for researchers to develop and implement strategies that improve HIV prevention and care for individuals who use stimulants, particularly those who also use opioids or other substances, while promoting diversity and community engagement in the research process.

This grant provides funding for researchers studying ancient sediments and fossils to better understand the Earth's history, environmental changes, and the evolution of life before the Holocene epoch.

This funding opportunity provides financial support to organizations that empower young leaders in Southeast Asia to tackle climate change and environmental challenges through leadership training, collaboration, and capacity-building initiatives.

This funding opportunity provides financial support for research aimed at improving the spread and implementation of effective health interventions, particularly in underserved communities, with a focus on promoting health equity and addressing health disparities.

The "Limited Competition: NIGMS Mature Synchrotron Resources for Structural Biology" grant aims to fund well-established structural biology resources at synchrotron facilities, with the goal of maintaining or upgrading them to current best practices, promoting their availability to the biomedical research community, and providing user training and support.

This grant provides funding for researchers and institutions to develop advanced imaging and biomarker technologies that improve the early detection of aggressive cancers and precancerous lesions, ultimately enhancing patient outcomes and clinical decision-making.

The National Institute on Aging is offering a grant for graduate students interested in aging-related research, providing funding and support for their doctoral dissertation projects and transition into postdoctoral positions in the field.

This funding opportunity provides additional financial support to active health services research projects facing unforeseen costs, helping researchers continue their work effectively.

This funding opportunity provides support for research projects that utilize health information technology to improve healthcare access, quality, and outcomes for underserved populations in the U.S. experiencing health disparities.

This funding opportunity supports researchers in developing innovative methods for modeling, analyzing, diagnosing, and controlling dynamic systems across various applications.

This funding opportunity is designed for U.S.-based small businesses to develop FDA-regulated treatments and diagnostic tools for individuals struggling with opioid and stimulant use disorders.

This funding opportunity supports innovative research in air-delivered munitions, targeting educational institutions, non-profits, and private companies, particularly small businesses, to advance technologies in weapon systems, sensors, and related fields for the Air Force.

This grant provides funding to exceptional U.S.-based graduate students transitioning from predoctoral to postdoctoral research in kidney, urologic, or hematologic sciences, encouraging diverse talent to contribute to these fields.