Grants for State governments - Income Security and Social Services
Explore 511 grant opportunities
Application Deadline
Jun 11, 2024
Date Added
Apr 13, 2024
Cooperative agreements under the Alzheimer's Disease Program Initiative (ADPI) Notice of Funding Opportunity (NOFO), are intended to support and promote the development and expansion of dementia-capable home and community-based service (HCBS) systems in States and Communities. There are two application options contained in this single NOFO: Grants to States (Option A) and Grants to Communities (Option B). No entity is eligible to apply for both State and Community options and no entity is eligible to hold more than one ADPI grant at a time. The dementia-capable systems resulting from program activities under either option are expected to provide quality, person-centered services and supports that help individuals living with dementia and their caregiver remain independent and safe in their communities.OPTION A: Grants to StatesApplicants for Option A (36 month cooperative agreements) are the governmental entities within states and territories designated as the state agency for dementia-capability and that have working relationships with their state agencies that enable creating and sustaining a dementia- capable HCBS System. Option A has two required objectives, the first of which is the creation, expansion and sustainability of a dementia-capable state HCBS system that includes Single Entry Point/No Wrong Door (SEP/NWD) access for people with dementia and their family caregivers. The second objective is to ensure access to a comprehensive, sustainable set of quality state HCBS that are dementia-capable and provide innovative services to the population with dementia and their caregivers.States and territories eligible for Option A are those that do not have active ACL ADPI State dementia-capability grants. All states without active grants are eligible to apply, however those states that have not benefited from ADSSP grants since before 2014 will be given priority consideration in the post-review decision-making process.OPTION B: Grants to CommunitiesCooperative agreements under Option B (36 month cooperative agreements) are available to private and/or public community-based organizations (CBO) that are able to: 1) demonstrate their operation within an existing dementia-capable HCBS system dedicated to the population that they serve; and 2) articulate opportunities and additional services in the targeted gap areas that would enhance and strengthen the existing system.Option B cooperative agreements are designed to aid community-based HCBS providers in addressing three specific service gaps in existing dementia-capable HCBS systems for persons living with or those at high risk of developing Alzheimers disease and related dementias (ADRD) and their caregivers.Option B applicants must address each of the following three gap areas:Provision of effective supportive services to persons living alone with ADRD in the community;Improvement of the quality and effectiveness of programs and services dedicated to individuals aging with intellectual and developmental disabilities with ADRD or those at high risk of developing ADRD; and Delivery of behavioral symptom management training and expert consultations for family caregivers.Community-based organizations are only eligible to hold one ADPI grant at a time. All community-based organizations without active ADPI grants are eligible to apply, however those that have not benefited from ADI-SSS and ADPI grant programs since before 2014 will be given priority consideration in the post-review decision-making process.
Application Deadline
May 10, 2024
Date Added
Dec 22, 2023
The Office of Child Support Services (OCSS) forecast provides information for eligible candidates interested in submitting applications for the Next Generation Child Support Employment Services Demonstration (NextGen). The NextGen program model is based on lessons learned from the National Child Support Noncustodial Parent Employment Demonstration. Its goal is to expand and enhance child support-led employment services for noncustodial parents. All state and tribal child support programs are eligible. Each applicant will self-identify into one of the following three mutually exclusive groups:Tribal child support agenciesState child support agencies where at least one local jurisdiction participating in the demonstration does not currently have an employment and training program or the program has been in operation for less than 5 yearsState child support agencies where all local jurisdictions participating in the demonstration have had an employment and training program in operation for at least 5 yearsAll groups are expected to implement their employment and training programs according to the program design elements described below. Deviations are allowed, but they must be justified, and the applicant must explain how they propose to handle the design elements described below.All groups are expected to provide the following child support and related services to noncustodial parents who receive employment and training services:Initiating and expediting order review and if appropriate modificationSuspending enforcement tools while participating in the program, including removing license suspensions and bench warrantsProviding debt reduction if permitted by state lawHelping with parenting time ordersWraparound services, such as fatherhood and parenting classes, substance abuse, or mental health services, are a plus but not required. OCSS anticipates that the grant recipient will partner with other agencies and programs to provide the employment and training services and other wraparound services.Experience shows that programs work best if each partner focuses on their core competencies. The child support program is expected to be the fiscal agent, manage the day-to-day operation of the program, and provide child support and related services, including those listed above. OCSS does not anticipate that child support staff will provide the employment and training services or wraparound services since these are not the child support program core competencies. These services may be paid for by the grant, but in most instances, they will be delivered by partnering agencies.This grant program will have a 60-month project period with five 12-month budget periods. Year 1 will focus on start-up and development of the program design. Years 2, 3, and 4 will be devoted to providing services, and the final year will be dedicated to evaluation, close-out, and sustainability work. Grant recipients will receive technical assistance and evaluation support from the recipient of the Technical Assistance and Evaluation of the Next Generation Child Support Employment Services Demonstration grant (see companion forecast). They will also participate in peer-to-peer learning opportunities.Recipients may receive between $350,000 and $2,102,941 over the 5-year project period. The award ceilings and floors for each project year is as follows:Year 1 (initial application): $588,235 ceiling and $100,000 floorYear 2: $588,235 ceiling and $100,000 floorYear 3: $308,824 ceiling and $50,000 floorYear 4: $308,824 ceiling and $50,000 floorYear 5: $308,824 ceiling and $50,000 floorOCSS anticipates that the budget requested will be scaled up or down according to the number of people served by the project.
Application Deadline
Not specified
Date Added
Sep 24, 2024
This funding opportunity provides financial support to municipalities and non-profit organizations in Connecticut for environmental assessment and cleanup of brownfield sites, particularly in underserved communities, to promote the creation of parks and recreational spaces.
Application Deadline
Aug 2, 2024
Date Added
Jun 24, 2024
The Donor Alliance Foundation is now accepting applications to fund efforts in Colorado and Wyoming that provide access to resources and education for those affected by organ and tissue donation and transplantation. Donor Name: Donor Alliance Foundation State: Colorado, Wyoming County: All Counties Type of Grant: Grant Deadline: (mm/dd/yyyy) 08/02/2024 Size of the Grant: $10,000 to $100,000 Grant Duration: 1 Year Details: The Donor Alliance Foundation was created to extend the mission of organ and tissue donation and transplantation, by building partnerships and breaking down barriers to influence change to positively affect the donation and transplant community. The Foundation believes that organ and tissue donation and transplantation are human gifts that save lives and that all those affected by donation deserve to be acknowledged, supported and given access to resources that enable the gift of life. The Foundation will continue its focus on community impact by addressing system barriers that prohibit people from receiving an organ and/or tissue transplant. They will do this by funding organizations that demonstrate equitable and equal access to donation and transplantation resources through education, family assistance, and/or research projects. To do this, the plan is to: Provide access to donation and transplantation resources for underinsured, vulnerable, and socio-economically disadvantaged populations and those living in rural areas of Colorado and Wyoming who are eligible for a transplant or already on the transplant list Further seeking projects that consider diversity, equity, and inclusion as a key audience and can demonstrate equity in their programming Look for applicants who are or planning to provide education or assistance to reach their audiences in new and innovative ways Remain nimble regarding changes or shifts needed to accomplish grantee goals or priorities Continued focus on Pancreas research and projects related to gathering data on the benefits of pancreas transplantation. Foundation Funds Efforts to meet the needs of patients pre- and post-transplant who have a financial need with limited or no access to funds. Projects that provide equal and equitable access to donation and transplantation resources that enable the gift of life. New and innovative education approaches about donation and transplantation to reach audiences in populations who may not be aware of their options, given reduced social interaction. Programs and services that offer grief assistance and compassion support in Colorado and Wyoming. Efforts to increase living donation. Medical and social research related to transplantation, to provide an opportunity to conduct pilot studies or early exploration (e.g., seed grants). Funding Information The Donor Alliance Foundation anticipates making grants ranging in size from $5,000 up to $25,000. Grant Period The Donor Alliance Foundation makes one-year grants. Eligibility CriteriaΒ The Donor Alliance Foundation accepts proposals from nonprofit community health-serving organizations, nonprofit hospitals, academic institutions, governmental agencies, foundations, and associations supporting donation and transplantation efforts. Applicants must be 501(c)(3) nonprofit organizations with tax-exempt classification from the Internal Revenue Service; be a tax-supported institution such as a hospital, government, or nonprofit organization; or must have a formal fiscal sponsorship arrangement with a tax-exempt organization. Organizations must be located in and serve Donor Allianceβs designated service area of Colorado and/or Wyoming. They will consider applications from partners in the following categories: Nonprofit hospitals (or their foundations) and/or transplant centers; or nonprofit foundations at for-profit hospitals Nonprofit community health-serving organizations Nonprofit organizations providing services to support donation and transplantation (e.g., grief centers, Ronald McDonald Houses) Academic institutions providing critical care training (e.g., nursing, medical or transplant technicians) Governmental agencies (emphasis on regional/rural public health departments)Β Non-profit Foundations Nonprofit Associations (transplant or medical related) Nonprofit regional chambers of commerce (funding transplant-related programs). Ineligibility For-profit companies or businesses Individuals Advocacy or lobbying work Sponsorships Scholarships Capital projects Other transplant-related causes (e.g., bone marrow, stem cell) Projects outside the service area. For more information, visit Donor Alliance.
Application Deadline
Nov 19, 2024
Date Added
Oct 20, 2023
This funding opportunity provides financial support for research aimed at improving resources and practices for caregivers and professionals who assist children with delayed language development, particularly focusing on underrepresented communities.
Application Deadline
Oct 7, 2024
Date Added
Mar 7, 2024
The purpose of the NIH Research Conference Grant (R13) is to support high quality conferences that are relevant to the public health and to the scientific mission of the participating Institutes and Centers.
Application Deadline
May 7, 2024
Date Added
May 12, 2020
The primary purpose of the NIH Mentored Clinical Scientist Research Career Development Awards (K08) program is to prepare qualified individuals for careers that have a significant impact on the health-related research needs of the Nation. This program represents the continuation of a long-standing NIH program that provides support and "protected time" to individuals with a clinical doctoral degree for an intensive, supervised research career development experience in the fields of biomedical and behavioral research, including translational research.
Application Deadline
Sep 1, 2024
Date Added
Aug 8, 2024
Applications are now being accepted for the Social Determinants of Health Grants. Donor Name: Intermountain Health State: Idaho, Utah County: Cassia County (ID), Minidoka County (ID) Type of Grant: Grant Deadline: (mm/dd/yyyy) 09/01/2024 Size of the Grant: $100,000 to $500,000 Grant Duration: 3 Years Details: To qualify for Social Determinants of Health grant funding, your program or service must align with at least one of Intermountainβs social determinants of health priorities, which are: Improve nutrition security Improve stable and quality housing through wraparound and support services Funding Information Applicants can request a total grant award between $50,000 and $300,000 for the entire project period. Projects can last between 18 and 36 months and must begin upon receipt of funding. A funding request may not exceed 20 percent of an organizationβs annual operating budget, e.g., to be eligible for a $50,000 grant, your organizationβs annual operating budget must be at least $250,000. In general, small equipment and materials, such as jump ropes or cooking utensils are eligible, at no more than a total $5,000 cost, but large equipment, construction, and capital costs are not eligible. Eligibility Criteria A social service agency and a healthcare agency apply in partnership: Social service agency is defined as a government, private or not-for-profit entity that provides a direct service/program that focuses on the needs of low-income, vulnerable populations and include state government agencies, local government agencies, and school districts Healthcare agency is defined as an organization that provides a billable healthcare service and uses evidence-based practices to provide a direct healthcare service OR a social agency applies on its own but demonstrate a collaborative approach with other health service agencies or provide strong health outcomes OR a health agency applies on its own but demonstrate collaborative approach with other social service agencies and provide strong health outcomes Requirements A full and complete financial audit within the last two years from application. Submission must include the full audit, including any findings or letter from the auditing firm A 501c3 designation letter or have a comparable government designation Completed W9 Completed Supplier Form (a blank copy will be provided in the application) If applying in a dual partnership, BOTH agencies must: Submit the required documentation above. Show a clear partnership that works together toward measurable goals and outcomes addressing one or more of the listed social determinants of health. You will be asked to clearly describe the planned role and responsibilities of each partner for all stages of the project or program. For more information, visit Intermountain Health.
Application Deadline
May 1, 2025
Date Added
Jul 23, 2024
The Office of Refugee Resettlement (ORR) within the Administration for Children and Families (ACF) anticipates funding for the Refugee Individual Development Accounts (RIDA) Program, which establishes and manages Individual Development Accounts (IDA) for low-income refugee participants. Eligible refugee participants who enroll in these projects will open and contribute systematically to IDAs for specified asset goals, including homeownership, business capitalization, vehicles for educational or work purposes, professional certification, and education (limited to postsecondary and/or continuing education, college entrance exam fees, (Test of English as a Foreign Language (TOEFL) and General Education Diploma(GED) preparation and test fees). Recipient organizations may use ORR funds to provide matches for the savings in the IDAs of up to $3,000 per individual refugee and $6,000 per refugee household.The match mentioned in this announcement does not refer to the award recipient finding additional funds to match funds being provided by the federal government; it is the portion of federal funds to be allocated for matching clients' IDA savings.Recipients will be expected to coordinate their policies and procedures for developing and administering refugee IDA projects with ORR and with the existing refugee IDA network.
Application Deadline
Aug 14, 2024
Date Added
Jul 10, 2024
The California Natural Resources Agency (CNRA) is excited to announce the Youth Community Access Program to expand outdoor access and build a healthier California. Donor Name: California Natural Resources Agency State: California County: All Counties Type of Grant: Grant Deadline:Β 08/14/2024 Size of the Grant: $100,000 to $500,000 Grant Duration: Grant Duration Not Mentioned Details: YEPEITA funds appropriated to the California Natural Resources Agency (the State) are to be used for competitive grants to support youth access to natural or cultural resources with a focus on low-income and disadvantaged communities. The grants may include, but are not limited to, Β community education and recreational amenities to support youth substance use prevention and early intervention. The Youth Community Access Grant Program is a competitive program to award grants to communities disproportionately affected by past federal and state drug policies, also known as the War on Drugs, as well as other underserved communities. The Youth Community Access Grant Program aims to be a resource to address and repair the multi-generational community impacts of the War on Drugs. Funding Priorities Projects containing one or more of the following elements will be given priority consideration in funding decisions: Projects in which youth participate in project planning, decision making, facilitation, and evaluation Projects in which youth participate in outreach and awareness campaigns Projects that empower youth to make healthy choices Projects that empower youth to make healthy choices Funding Information The maximum award for an individual project is $300,000. The minimum award is $25,000. Eligibility Criteria Eligible applicants include local, state, and federal agencies; nonprofit organizations; and federally recognized Native American tribes. Nonprofit organizations are defined as any nonprofit public benefit corporation that is formed pursuant to the Nonprofit Corporation Law, incorporated for a minimum of two years, qualified to do business in California, and qualified as a tax-exempt 501(c)(3) organization under the US Internal Revenue Code. Requirements To be eligible for funding, projects must meet ALL the following program requirements: Project must serve youth. For the purposes of this program, youth is defined as a person between the ages of birth and 26 years old. Project must directly support youth access to either natural or cultural resources. Project must include design features and program elements to promote youth health, safety, well-being, and comfort. For more information, visit CNRA.
Application Deadline
Jul 8, 2024
Date Added
Jun 11, 2024
The U.S. Department of Justice (DOJ), Office of Justice Programs (OJP), Office for Victims of Crime (OVC) is seeking applications for funding. OJP is committed to advancing work that promotes civil rights and equity, increases access to justice, supports crime victims and individuals impacted by the justice system, strengthens community safety, protects the public from crime and evolving threats, and builds trust between law enforcement and the community.With this solicitation, OVC seeks to support (1) the development or expansion of Sexual Assault Nurse Examiner/Sexual Assault Forensic Examiner (SANE/SAFE) programs using a coordinated community response strategy and (2) the provision of training and technical assistance (TTA).This program furthers the DOJs mission to uphold the rule of law, to keep our country safe, and to protect civil rights.
Application Deadline
May 26, 2025
Date Added
Jul 31, 2024
This funding opportunity supports state, tribal, and local agencies, along with research institutions, in evaluating consumer education strategies to help parents make informed choices about early child care and education.
Application Deadline
Jun 7, 2024
Date Added
Apr 5, 2024
**A modification to this NOFO was made on April 4, 2024. There are no content changes to application or program requirements. The funding opportunity number was changed from HHS-2024-ACF-ACYF-CW-0056 to HHS-2024-ACF-ACYF-CT-0056. There were changes made in Section I, Statutory Authority; and Section II, Expected Number of Awards and Estimated Total Funding. In Section III, Eligibility was changed to exclude for-profit organizations and small businesses. American Indian and Alaska Native (AI/AN) children are nearly 3 times more likely to enter foster care, compared to non-Native children. These four year grants are intended to generate evidence for how best to effectively implement child welfare practices and ongoing active efforts to maintain AI/AN families by funding state and tribal partnerships to jointly design and operate Indian child welfare best practice implementation demonstration sites. The evidence generated and lessons learned through this effort are intended to contribute to implementation efforts nationally to help maintain and preserve AI/AN families and allow their children to remain connected to their communities and cultures. The purpose of this notice of funding opportunity is to create and implement intergovernmental partnership models to improve implementation of child welfare best practices that are culturally appropriate for federally recognized AI/AN children to prevent maltreatment, removal from families and communities, and improve safety, permanency, and well-being. Recipients will serve as demonstration sites to design and implement projects to effectively implement culturally appropriate best practices in Indian child welfare, including measuring improvements in child welfare practice, Indian child welfare codes, legal and judicial processes, case monitoring, case planning, data collection, in-home family preservation services, infrastructure, and systems change. Partnerships must include the state Court Improvement Program, the state child welfare agency, and one or more tribal governments or tribal consortia including corresponding tribal court(s). The "Tribal government" partner(s) may be tribal child welfare agencies where appropriate under tribal law or custom.Effective culturally appropriate best practices for implementation require a high degree of collaboration between state and tribal courts and Indian child welfare agencies. Thus, both states and tribes must identify, build, and enhance necessary capacities. State/tribal collaborations will work together to craft solutions for longstanding challenges to providing effective best practices in Indian child welfare in ways that work best for their communities. This funding opportunity is intended to encourage state and tribal governments to work together to find creative, rational ways to meet the needs of AI/AN families with culturally appropriate best practices in Indian child welfare, with active efforts to retain or reunite Indian children with family as the gold standard for best Indian child welfare practice. The award also provides an important opportunity for states and tribes to build or strengthen relationships of trust by working together toward common family preservation goals. As part of the project, recipients may also consider the role of civil legal services in implementation efforts. Assessment of the success and/or need for legal representation to parties in Indian child welfare cases may be included in project work, as may provision of direct civil legal services, to the extent that such legal services are an identified part of a pilot or practice model to be tested.For purposes of this funding opportunity, "Tribal courts" are defined consistent with the Bureau of Indian Affairs regulations as "a court with jurisdiction over child custody proceedings and which is either a Court of Indian Offenses, a court established and operated under the code or custom of an Indian tribe, or any other administrative body of a tribe which is vested with authority over child custody proceedings.
Application Deadline
Oct 16, 2024
Date Added
Sep 26, 2024
This grant aims to address the issue of illegal solid waste dumping in California, which negatively affects property values, public health, and community pride, by providing funds for the cleanup and restoration of abandoned or underutilized properties.
Application Deadline
May 6, 2024
Date Added
May 3, 2024
The Greenhouse Accelerator Program Juntos Crecemos Edition is a five-month, mentor-guided program to support the acceleration of emerging Hispanic food and beverages innovations that are transforming the way consumers live their lives. Donor Name: PepsiCo State: All States County: All Counties Type of Grant: Program Deadline: 05/06/2024 Size of the Grant: $10,000 to $100,000 Grant Duration: Grant Duration Not Mentioned Details: This edition is an extension of the initial Greenhouse Accelerator program launched in 2018, in collaboration with PepsiCo Juntos Crecemos, part of PepsiCoβs Pep+ transformation agenda, designed to provide short and long-term support to Hispanic small businesses. The mission is to identify up to 8 high-potential emerging Hispanic-owned food and beverage consumer packaged goods small businesses. Driving growth for Hispanic founders in the food and beverage industry with operating businesses in the U.S. Program Benefits What the Greenhouse Accelerator can offer you: Grants Guaranteed $20,000 USD grant for each finalist. Winner awarded an additional $100,000 USD Guidance Expert guidance and learning modules across all aspects of business development Network Access and exposure to PepsiCo network and resources, industry experts, VCs and investors Collaboration Unlocking of potential collaboration opportunities with PepsiCo Mentorship Hands-on mentorship and support for refining business models, fortifying strategies, and enhancing impact Growth Accelerated pathways to launch, scale, and grow your breakthrough innovations. Eligibility RequirementsΒ Net-revenue between $100,000 to $2,000,000 USD in the last financial year Be a Hispanic-owned business licensed and operating in the United States Be willing to work with PepsiCo Greenhouse Accelerator mentors and public relations team throughout six-month Accelerator program and attend Accelerator events. An external third party will review all submissions. The selection committee will choose finalists based on the following criteria: A clear go-to-market strategy and plan for sustained in-market execution Post-prototype, ready for review with a multinational corporation or company Uniqueness in the market Balanced gender and ethnic diversity Clear & active social responsibility mission aligned with PepsiCoβs Juntos Crecemos Strategy Aligned with PepsiCoβs PepsiCo Positive Strategy Scalable business model. For more information, visit PepsiCo.
Application Deadline
Mar 11, 2025
Date Added
Dec 15, 2022
This funding opportunity supports early-career researchers transitioning to independent academic positions, focusing on innovative studies involving human participants to advance understanding and treatment of pain and substance use disorders.
Application Deadline
Jul 10, 2024
Date Added
Jun 4, 2024
The Glass Recycling Foundationβs grant program is intended to increase glass recovery and diversion from landfills and to connect glass generators with end markets. Donor Name: Glass Recycling Foundation State: All States County: All Counties Type of Grant: Grant Deadline: (mm/dd/yyyy) 07/10/2024 Size of the Grant: Not Available Grant Duration: Grant Duration Not Mentioned Details: The Glass Recycling Foundation (GRF) is a non-profit foundation dedicated to raising funds for and distributing funds to intervention, demonstration and pilot projects that address gaps in the glass recycling supply chain across the United States. Eligible Projects Projects should prioritize circularity by ensuring glass is recycled into the highest and best use. Projects that show that glass will go back into the supply chain for manufacturing of products will be most likely to be funded. Additionally, applicants should outline a clear plan and strategy for how their project will be implemented. The two categories of projects allowed under the grant program are demonstration projects and education. Demonstration Projects β Should address specific gaps in the glass recycling supply chain and provide alternative strategies for strengthening glass end markets. Examples of potential projects: Equipment for cleaning recycled glass Collection containers for glass drop-offs Setting up regional strategies for building collection and storage infrastructure for recycled glass Haulers/hauling systems to increase collection Education Projects β The projects need to present a clear message and strategy for educating the public about the environmental and community benefits of recycling glass and improving the quality of diverted materials from residents. Examples of potential projects: Developing and presenting trainings about more effective glass collection and recycling practices Writing and disseminating case studies and guidance documents about the best management practices for effective glass collection and recycling practices Developing signage for residential glass recycling drop-offs Developing and disseminating ads/public education campaigns about how to recycle glass in the community. Eligibility Criteria Nonprofit entities Municipal, county, city, and state governments Public waste management districts Publicly owned/operated MRFs or service providers. For more information, visit GRF.
Application Deadline
May 1, 2025
Date Added
Jul 23, 2024
This funding opportunity provides financial support to eligible organizations for developing agricultural training and services that improve the livelihoods and well-being of refugee families in the U.S.
Application Deadline
Sep 6, 2024
Date Added
Mar 1, 2024
This FOA solicits applications for new Behavioral and Social Sciences Research (BSSR) predoctoral training programs that focus on innovative computational and/or data science analytic approaches and their incorporation into training for the future BSSR health research workforce. The vision of the Advanced Data Analytics for BSSR training program is to support the development of a cohort of specialized predoctoral candidates who will possess advanced competencies in data science analytics to apply to an increasingly complex landscape of behavioral and social health-related big data. This Notice of Funding Opportunity (NOFO) does not allow appointed Trainees to lead an independent clinical trial but does allow them to obtain research experience in a clinical trial led by a mentor or co-mentor.
Application Deadline
Jun 7, 2024
Date Added
May 8, 2023
Reissue of RFA-MH-22-115 to comply with DMSP policy. The purpose of this Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is to encourage applications that will develop and validate novel tools to facilitate the detailed analysis and manipulation of complex circuits and provide insights into cellular interactions that underlie brain function. Critical advances in the treatment of brain disorders in human populations are hindered by our lack of ability to monitor and manipulate circuitry in safe, minimally-invasive ways. Clinical intervention with novel cell and circuit specific tools will require extensive focused research designed to remove barriers to delivery of gene therapies. In addition to identification and removal of barriers, the need to specifically target dysfunctional circuitry poses additional challenges. Neuroscience has experienced an impressive influx of exciting new research tools in the past decade, especially since the launch of the BRAIN Initiative. However, the majority of these cutting edge tools have been developed for use in model organisms, primarily rodents, fish and flies. These cutting edge tools, such as viral delivery of genetic constructs, are increasingly adaptable to large brains and more importantly are emerging as potential human therapeutic strategies for brain disorders. A pressing need to develop tools for use in large brains, more directly relevant to the human brain is the focus of this initiative. The new tools and technologies should inform and/or exploit cell-type and/or circuit-level specificity. Plans for validating the utility of the tool/technology will be an essential feature of a successful application.