Grants for For profit organizations other than small businesses - Science and Technology

The MBRP TTDA is a product-driven award mechanism intended to provide support for the translation of promising preclinical findings into products for clinical application in resource-limited settings, particularly within the pre-hospital, or early, acute phase of care environments. Applications must address one or more of the critical gaps included in the FY24 MBRP TTDA Focus Areas. Products under development must address the needs of military Service Members, Veterans, their beneficiaries, and the American public.The product(s) to be developed may be a tangible item such as a medical device or pharmacologic agent (including, but not limited to, drugs or biologics). Knowledge products may be considered, provided that the knowledge is applicable to a technology or therapeutic under development. (A knowledge product is a non-materiel product that addresses an identified need in one or more of the FY24 MBRP TTDA Focus Areas. A knowledge product is based on current evidence, aims to transition clinical practice standards, training, or tools into clinical practice, or supports materiel solutions [systems to develop, acquire, provide, and sustain medical solutions and capabilities], and educates or impacts behavior throughout the continuum of care, including primary prevention of negative outcomes.)At the time of pre-application submission the proposed product must have achieved a minimum technology readiness level (TRL) or knowledge readiness level (KRL) of 3 (Appendix II).Proof-of-concept AND a prototype/preliminary version of the proposed product demonstrating its potential utility must be established at the time of pre-application submission. Applications must include relevant data that support the rationale for the proposed study. These data may be unpublished and/or from the published literature.This award mechanism is intended to facilitate progression of research that is supported by significant preliminary data but has not yet advanced to the level of clinical use. Examples of the types of research that may be supported include, but are not limited to: Testing new therapeutic or technologic modalities (e.g., agents, delivery systems, chemical modification of lead compounds, device testing and/or validation) using established or validated preclinical systems Designing pilot or full-scale Good Manufacturing Practice (GMP) production of therapeutics and/or technologies for use in advanced preclinical studies Developing pharmacologic agents through absorption, distribution, metabolism, excretion, and toxicity studies Investigational New Drug- or Investigational Device Exemption-enabling studiesClinical trials and clinical research studies ARE NOT PERMITTED under this award mechanism. Projects involving limited use of commercially available human cells or anatomical specimens are permitted, provided that the use of such specimens is necessary for device or product development. Applicants interested in proposing clinical research should consider submitting to the FY24 MBRP Patient-Centered Research Award mechanism (HT942524MBRPPCRA).A clinical trial is defined in the Code of Federal Regulations, Title 45, Part 46.102 (45 CFR 46.102) as a research study in which one or more human subjects are prospectively assigned to one or more interventions (which may include a placebo or another control) to evaluate the effects of the interventions on biomedical or behavioral health-related outcomes.Studies that do not seek to measure safety, effectiveness, and/or efficacy outcome(s) of an intervention are not considered clinical trials.For the purposes of this funding opportunity, research that meets the definition of a clinical trial is distinct from clinical research. Clinical research encompasses research with human data, human specimens, and/or interaction with human subjects. Clinical research is observational in nature and includes:(1) Research conducted with human subjects and/or material of human origin such as data, specimens, and cognitive phenomena for which an investigator (or co-investigator) does not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention. Research meeting this definition may include but is not limited to: (a) mechanisms of human disease, (b) diagnostic or detection studies (e.g., biomarker or imaging), (c) health disparity studies, and (d) development of new technologies.(2) Epidemiologic and behavioral studies that do not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention.(3) Outcomes research and health services research that do not fit under the definition of clinical trial.Excluded from the definition of clinical research are in vitro studies that utilize human data or specimens that cannot be linked to a living individual and meet the requirements for exemption under 46.104(d)(4) of the Common Rule.Impact: The overall impact of the proposed research is a key component of this award mechanism. High-impact research will, if successful, lead to the development and translation of therapeutic or technologic advances for clinical application in the care of burn-injured casualties, such as detection, diagnosis, treatment, or burn complication prevention.Relevance to Military Health: Relevance to the health care needs of burn-injured military Service Members is a key feature of this award.Use of DOD or Department of Veterans Affairs (VA) Resources: Applications involving multidisciplinary collaborations among academia, industry, the military Services, the VA, and other federal government agencies are highly encouraged. These relationships can leverage knowledge, infrastructure, and access to unique clinical populations that the collaborators bring to the research effort, ultimately advancing research that is of significance to Service Members, Veterans, and/or their Families. If the proposed research relies on access to unique resources or databases, the application must describe the access at the time of submission and include a plan for maintaining access as needed throughout the proposed research. Applicants are encouraged to integrate and/or align their research projects with DOD and/or VA research laboratories and programs. Collaboration with DOD or VA investigators is also encouraged. A list of websites that may be useful in identifying additional information about ongoing DOD and VA areas of research interest or potential opportunities for collaboration can be found in Appendix IV.Rigor of Experimental Design: All projects should adhere to a core set of standards for rigorous study design and reporting to maximize the reproducibility and translational potential of preclinical research. The standards are described in SC Landis et al., 2012, A call for transparent reporting to optimize the predictive value of preclinical research, Nature 490:187-191 (www.nature.com/nature/journal/v490/n7419/full/nature11556.html). While these standards are written for preclinical studies, the basic principles of randomization, blinding, sample-size estimation, and data handling derive from well-established best practices in clinical studies. Projects that include research on animal models are required to submit Attachment 8, Animal Research Plan, as part of the application package to describe how these standards will be addressed. Applicants should consult the ARRIVE guidelines 2.0 (Animal Research: Reporting In Vivo Experiments) to ensure relevant aspects of rigorous animal research are adequately planned for and, ultimately, reported. The ARRIVE guidelines 2.0 can be found at https://arriveguidelines.org/arrive-guidelines.The CDMRP expects to allot approximately $4.4M to fund approximately two MBRP Technology/Therapeutic Development Award applications. Funding of applications received is contingent upon the availability of federal funds for this program as well as the number of applications received, the quality and merit of the applications as evaluated by scientific and programmatic review, and the requirements of the government. Funds to be obligated on any award resulting from this funding opportunity will be available for use for a limited time period based on the fiscal year of the funds. It is anticipated that awards made from this FY24 funding opportunity will be funded with FY24 funds, which will expire for use on September 30, 2030.The funding instrument for awards made under the program announcement will be assistance agreements, contracts, or Other Transactions. The type of instrument used to reflect the business relationship between the organization and the government is at the discretion of the government, in accordance with the Federal Grant and Cooperative Agreement Act of 1977, as amended, 31 USC 6301-6308, which provides the legal criteria to select a procurement contract or an assistance agreement. The USAMRDC will also consider the use of Other Transactions (OTs) as a vehicle for award, in accordance with the conditions in 10 USC 4021 and 10 USC 4022.An assistance agreement can take the form of a grant or cooperative agreement. The level of government involvement during the projects period of performance is the key factor in determining whether to award a grant or cooperative agreement. If no substantial government involvement is anticipated, a grant will be made (31 USC 6304). Conversely, if substantial government involvement is anticipated, a cooperative agreement will be made (31 USC 6305). Substantial involvement means that members of the U.S. government will assist, guide, coordinate, or participate in project activities.A contract is required when the principal purpose of the instrument is to acquire property or services for the direct benefit or use of the U.S. government.An Other Transaction will also be considered as a vehicle for award under this BAA, in accordance with 10 USC 4021 and 10 USC 4022. The OT authorities were created to give DOD the flexibility necessary to adopt and incorporate business practices that reflect commercial industry standards and best practices into its award instruments. When leveraged appropriately, OTs provide the government with access to state-of-the-art technology solutions from traditional and non-traditional defense contractors (NDCs), through a multitude of potential teaming arrangements tailored to the particular project and the needs of the participants. OTs can help to foster new relationships and practices involving traditional and NDCs, especially those that may not be interested in entering into FAR-based contracts with the government; broaden the industrial base available to government; support dual-use projects; encourage flexible, quicker, and cheaper project design and execution; leverage commercial industry investment in technology development and partner with industry to ensure DOD requirements are incorporated into future technologies and products; and collaborate in innovative arrangements. OTs are not FAR-based procurement contracts, grants, cooperative agreements, or cooperative research and development agreements.The award type, along with the start date, will be determined during the negotiation process.The anticipated total costs budgeted for the entire period of performance for an FY24 MBRP Technology/Therapeutic Development Award should not exceed $2.2M. Refer to Section II.D.6, Funding Restrictions, for detailed funding information.Awards supported with FY24 funds will be made no later than September 30, 2025. For additional information refer to Section II.F.1, Federal Award Notices.

The MMRDA mechanism is intended to fund the logical continuation of previously DOD-funded research or development efforts relevant to the above FY24 JWMRP Focus Areas with the highest potential to augment and accelerate medical product development and health care solutions for active-duty Service Members, their Families, Veterans, and/or the American public. Collaboration with DOD organizations is encouraged when this alliance would contribute to the success of the research effort, and any funds designated for DOD laboratories or activities should be identified in the application/proposal through submission of a Suggested Intragovernmental/Intramural Budget Form, Attachment 15. Applications/proposals from small businesses and/or partnerships with industry are also encouraged. The MMRDA mechanism supports a wide range of research projects, spanning late-stage preclinical studies, late-state technology development efforts, technology demonstration, and translational research. A Clinical Research or Clinical Trial Option is available to specifically support clinical research/observational studies, all phases of clinical trials/interventional studies, and/or correlative studies in support of the development of promising pharmaceutical or biologic candidates, medical devices, and technologies. Note: Applications/proposals submitted under this option will be required to submit additional relevant application/proposal materials.

In FY23, the OCRP established a new academy, the Ovarian Cancer Clinical Trial Academy (OCCTA), which will focus on clinical trial research in ovarian cancer. The intent of the OCCTA is to enhance knowledge within next generation of Early-Career Investigators (ECIs) in clinical trial research and to produce effective treatments and cures for ovarian cancer. The OCCTA will bring together established investigators (the Academy Dean and Assistant Dean), established Career Guides (mentors), and a group of ECIs/Scholars to conduct successful, highly productive clinical trials in ovarian cancer. The OCCTA strives to develop successful, highly productive ovarian cancer clinical trialists in a collaborative research and career development environment, providing intensive mentoring, national networking, collaborations, and a peer group for junior clinical trialists. The OCCTA, through its Leadership, provides for professional and leadership development of the ECIs to include skills and competencies needed to execute clinical trials.

The COVID-19 Relief – Supporting Elm and Main (SEAM) program will provide financial assistance to the community revitalization organizations dedicated to community and economic development in older and historic downtowns, commercial districts, and neighborhoods according to the principles of the Elm Street and Main Street Approaches. The program, supported by Keystone Communities funding, is intended to assist Elm Street and Main Street organizations that have been economically impacted by COVID-19. Financial Info: The COVID-19 Relief – Supporting Elm and Main (SEAM) program will provide financial assistance to the community revitalization organizations dedicated to community and economic development in older and historic downtowns, commercial districts, and neighborhoods according to the principles of the Elm Street and Main Street Approaches. The program, supported by Keystone Communities funding, is intended to assist Elm Street and Main Street organizations that have been economically impacted by COVID-19.

The CHIPS Research and Development Program (CHIPS R) aims to advance the development of semiconductor technologies and to enhance the competitiveness of the U.S. semiconductor industry. This is the first Notice of Funding Opportunity under this program. It seeks applications for new research and development (R) activities to establish and accelerate domestic capacity for advanced packaging substrates and substrate materials, a key technology for producing microelectronics systems. This NOFO seeks applications for research and development activities that will establish and accelerate domestic capacity for advanced packaging substrates and substrate materials. Through this NOFO, the NAPMP program seeks to achieve the following objectives: (1) Accelerate domestic R&D and innovation in advanced packaging materials and substrates; (2) Translate domestic materials and substrate innovation into U.S. manufacturing, such that these technologies are available to U.S. manufacturers and customers, including to significantly benefit U.S. economic and national security; (3) Support the establishment of a robust, sustainable, domestic capacity for advanced packaging materials and substrate R&D, prototyping, commercialization, and manufacturing; and (4) Promote a skilled and diverse pipeline of workers for a sustainable domestic advanced packaging industry. NAPMP plans to release subsequent NOFOs relevant to other research areas and for an Advanced Packaging Piloting Facility (APPF), where successful development efforts will be transitioned and validated for scaled transition to U.S. manufacturing. The APPF is expected to be a key facility for technology transfer to high-volume manufacturing.

The "Ideas Lab: Breaking the Low Latency Barrier for Verticals in Next-G Wireless Networks" grant aims to fund research and development initiatives that seek to overcome technical challenges in 5G and next-generation wireless networks, with the goal of achieving consistently low-latency performance necessary for the success of emerging industries, through collaborative brainstorming, prototyping, and testing of innovative solutions.

The First Literacy Grants provide funding that stimulates and supports the development, trial, and implementation of innovative and impactful Adult Basic Education (ABE) resources and practices. Donor Name: First Literacy State: Massachusetts County: All Counties Type of Grant: Grant Deadline: 05/02/2024 Size of the Grant: $10,000 to $100,000 Grant Duration: 1 Year Details: Priorities To fund innovative and impactful ideas that will improve educational and professional outcomes for the students of ABE organizations. To fund ideas that may not be able to be funded through Massachusetts Department of Elementary & Secondary Education (DESE) or other major funding sources. To fund ideas that will have a lasting impact in ABE schools and organizations. Grant Levels First Literacy is offering three (3) types of grants: Program Grants, Organization Wide Grants and Incentive Grants Program Grants- Program grants provide funding for the development, trial, and implementation of innovative and impactful ABE or ESOL teaching and learning resources and practices that are project-based, fresh approaches to instruction, curriculum and staff development, and related areas. New Organizations Organizations that have not received a First Literacy Grant in the past ten years are eligible to apply for up to $7,500 in the first year of the proposed project. Returning Organization Organizations that received a First Literacy Grant in the past ten years can apply for up to $5,000 in the first year of the proposed project. Organization-Wide Grants These grants provide funding for innovative ideas for larger-scale, organization-wide curricula, systems, training, and/or teacher improvement. Grants of up to $15,000 are available and priority is given to projects with a robust data reporting plan. Incentive Grants Second Year Grant- Organizations that received First Literacy funding for the first year of a project are eligible to apply for up to half of their first-year grant amount in a second year of funding. Organizations applying for a second-year grant must replicate the program with fidelity in year two including capturing pertinent data and reporting that to First Literacy. Organizations apply for a second-year grant using the main grant application, along the same time as the program and organizational grants Program Replication Grant- Your organization and another organization can each receive $1,000 if: You assist a second organization in implementing your grant idea/program. Both organizations must submit a brief letter of intent to apply for this grant along with the FY 25 grant cycle. Project Period The grant period is from July 1, 2024 through June 30, 2025. Eligibility Criteria Grants are open to all not-for-profit Adult Basic Education (ABE) and English for Speakers of Other Languages (ESOL) organizations in Massachusetts. For more information, visit First Literacy.

The Distributed Array of Small Instruments (DASI) solicitation is designed to address the increasing need for high spatial and temporal resolution measurements to determine the local, regional, and global scale processes that are essential for addressing the fundamental questions insolar and space physics. This solicitation will be formally divided into two tracks: 1) development of instrumentation for future deployment in arrays and 2) deployment and operation of existing instruments in distributed arrays.This DASI solicitation emphasizes both strong scientific merit and a well-developed plan for student training and involvement of a diverse workforce.

The United States is made up of regional systems comprising interdependent urban and rural systems and every community category between urban and rural. Urban systems and rural systems are interdependent for the provisioning of food, energy sources, water, other materials and natural resources, markets, manufactured goods, and medical resources. These systems are also connected by ecological processes that both influence and are influenced by human behavior. The vital interconnection of urban-rural systems underscores the critical need for the advancement of sustainable regional systems (SRS). The goal of this solicitation is to fund convergent research and education that will advance sustainable regional systems science, engineering, and education to facilitate the transformation of current regional systems to enhance sustainability. To further the advancement of SRS science, engineering, and education, NSF will support proposals for Sustainable Regional Systems Research Networks (SRS RNs). Sustainable regional systems are connected urban and rural systems that are transforming their structures and processes collaboratively with the goal of measurably and equitably advancing the well-being of people and the planet. The purpose of the SRS RNs competition is to develop and support interdisciplinary, multi-organizational teams working collaboratively to produce cutting-edge convergent research, education, and outreach that addresses grand challenges in sustainable regional systems. SRS RNs will study multiscale regional systems to further SRS science, engineering, and education. Key elements will include new data, methods, and models to understand interactions between natural, human-built, and social systems; improved understanding of interdependencies, mutual benefits, and trade-offs of different wellbeing outcomes for humans and the environment; new and generalizable theories of change relevant to SRS;theco-production of knowledge; andexploration of conceptsof social equity in sustainable regional systems across spatial and temporal scales. SRS RN outcomes will have the potential to inform societal actions for sustainability across urban systems and the connected rural communities that make up regional systems. Subject to availability of funds and quality of proposals, this SRS RN solicitation will support: SRS RN Awards.These awards will supportfundamental convergent research, education, and outreach that addressesengineering, chemistry, biology, geosciences, mathematics, statistics, environmental, data, computational, education, and social, behavioral, and economic sciences ofsustainable regional systems in partnerships thatmay embrace universities, colleges, federal, state, and local governments, tribal communities, non-governmental and international bodies, non-profit organizations, industry, practitioners, and other community groups. The award size is up to $15 million totalwith a duration of 5 years. SRS RNs will conduct innovative and pioneering fundamental research and education that is of a scale and complexity that would not be possible within a single organization, center, or through the normal collaborative modes of NSF research support in core programs.

This funding opportunity provides financial support to Virginia-based technology companies in the early stages of development to help them validate their products and grow their businesses in the state.

This program provides financial assistance to business owners and developers in the South Cape area of Cape Coral, Florida, to help cover site development costs for new construction or renovations, with a focus on job creation and economic growth.

This grant provides financial support to small- and medium-sized technology businesses in Colorado to help them export their products and services to new international markets.

This funding opportunity supports innovative research projects aimed at developing transformative energy technologies that can significantly reduce energy consumption and greenhouse gas emissions in the U.S.

An Ideas Lab is an intensive meeting that brings together multiple diverse perspectives to focus on finding innovative cross-disciplinary solutions to a grand challenge problem (see below and PAPPG Chapter II.F.6. for more information about this type of proposal). The goal of the Personalized Engineering Learning Ideas Lab is to extend engineering education research to enable advanced personalization in pedagogy and assessment in a K-12 or higher education context. The following broad areas have been identified as possible avenues to advance knowledge: personalized engineering education, multimodal sensing for personalized learning systems and team-based personalized learning. This Ideas Lab aims to bring together experts from diverse scientific, engineering and education backgrounds to develop innovative technologies and solutions to achieve personalized learning for engineering education. This Ideas Lab is organized by the Office of Emerging Frontiers and Multidisciplinary Activities (EFMA), the Division of Engineering Education and Centers (EEC), and the Division of Civil, Mechanical and Manufacturing Innovation in the Directorate for Engineering (ENG); the Division of Information and Intelligent Systems (IIS) in the Directorate for Computer and Information Science and Engineering (CISE); the Division of Behavioral and Cognitive Sciences in the Directorate for Social, Behavioral and Economic Sciences (SBE); the Division of Graduate Education, the Division of Research on Learning in Formal and Informal Settings, and the Division of Undergraduate Education in the Directorate for STEM Education (EDU); and the Division of Translational Impacts in the Directorate for Technology, Innovation and Partnerships (TIP). INFORMATIONAL WEBINAR: The Emerging Frontiers and Multidisciplinary Activities (EFMA) Office will host an informational webinar in October 2023 to discuss the Ideas Lab: Personalized Engineering Learningsolicitationandtoanswer questions. Details on how to join this webinar will be posted on the EFMA Website.

This funding opportunity supports research projects that improve medical and human performance capabilities for military personnel, focusing on innovative solutions for Special Operations Forces in challenging environments.

This funding opportunity supports a wide range of behavioral and social science research aimed at enhancing the effectiveness and readiness of the U.S. Army, inviting proposals from universities, nonprofits, and private organizations.

This program provides funding for innovative research projects that improve our understanding and application of thermal transport processes, targeting scientists and engineers working in fields like thermodynamics, fluid mechanics, and heat transfer.

This grant provides funding for researchers to explore and develop innovative solutions related to interfacial phenomena and engineering, with a focus on improving chemical and biochemical processes in industry.

The Plant Genome Research Program (PGRP) supports genome-scale research that addresses challenging questions of biological, societal and economic importance. PGRP encourages the development of innovative tools, technologies and resources that empower a broad plant research community to answer scientific questions on a genome-wide scale. Emphasis is placed on the scale and depth of the question being addressed and the creativity of the approach. Data produced by plant genomics should be usable, accessible, integrated across scales and of high impact across biology. Training, broadening participation, and career development are essential to scientific progress and should be integrated in all PGRP-funded projects. Two funding tracks are currently available: RESEARCH-PGR TRACK: Genome-scale plant research to address fundamental questions in biology, including processes of economic and/or societal importance. TRTech-PGR TRACK: Tools, resources and technology breakthroughs that further enable functional plant genomics.

The Division of Integrative Organismal Systems (IOS) Core Programs Track supports research to understand why organisms are structured the way they are and function as they do. Proposals are welcomed in all of the core scientific program areas supported by the Division of Integrative Organismal Systems (IOS). Areas of inquiry include, but are not limited to, developmental biology and the evolution of developmental processes, development, structure, modification, function, and evolution of the nervous system, biomechanics and functional morphology, physiological processes, symbioses and microbial interactions, interactions of organisms with biotic and abiotic environments,plant and animal genomics, and animal behavior. Proposals should focus on organisms as a fundamental unit of biological organization. Principal Investigators are encouraged to apply systems approaches that will lead to conceptual and theoretical insights and predictions about emergent organismal properties. The IntBIOTrackinvites submission of collaborative proposals totackle bold questions in biology thatrequire an integrated approach to make substantive progress. Integrative biological research spans subdisciplines and incorporates cutting-edge methods, tools, and concepts from each to produce groundbreaking biological discovery that is synergistic, such that the sum is greater than the parts. The research should produce a novel, holistic understanding of how biological systems function and interact across different scales of organization, e.g., from molecules to cells, tissues to organisms, species to ecosystems and the entire Earth.Where appropriate, projects should apply experimental strategies, modeling, integrative analysis, advanced computation, or other research approaches to stimulate new discovery and general theory in biology.