Grants for Nonprofits - Science and Technology

This funding opportunity supports independent researchers at U.S. nonprofit or academic institutions in advancing promising cancer research from preclinical stages to human testing.

This funding opportunity provides financial support to nonprofit organizations for energy efficiency upgrades to their buildings, helping them reduce energy costs and emissions while redirecting savings towards their core missions.

The North Carolina GlaxoSmithKline Foundation offers $50,000 grants to North Carolina community-based nonprofit organizations for new projects or for expanding/enhancing existing programs in science, health, and education. Projects should address critical community needs identified through comprehensive assessments, align with local agency goals, and demonstrate sustainability post-funding. Grants do not support core mission, general operating costs, construction/renovation projects, medical services, or equipment. Grant renewed every year. Annual Fall deadline: October 1st

The "Clinical Studies of Orphan Products Addressing Unmet Needs of Rare Diseases (R01) Clinical Trials Required" grant aims to fund clinical trials that test the effectiveness and safety of new treatments for rare diseases, with the goal of increasing the number of approved treatments for these conditions.

The intent of the FY24 ERP IDA is to solicit novel, innovative research that has the potential to increase our understanding of PTE to improve quality of life, especially in Service Members, Veterans, and/or their care partners. The work should innovatively challenge existing research paradigms or exhibit high levels of creativity. The FY24 ERP IDA offers two levels of funding dependent upon the level of experience of the Principal Investigator (PI). Funding Level I - Pathway to Independence Option: Early-career investigators ranging from the postdoctoral level (e.g., research associate, fellows, residents, or equivalent) to within 3 years of their first independent faculty position (or equivalent) may be named by the organization as the PI on the application (mentor required). Funding Level II - Innovative New Direction Option: Investigators at all career levels may be named by the organization as the PI on the application.

The Community Reinvestment Fund is a capital grant program established by the Delaware General Assembly, designed to foster community redevelopment, revitalization, and investment capital projects. Its overarching mission is to improve the economic, cultural, historical, and recreational health of Delaware communities. This program aligns with a strategic priority to enhance local well-being and stimulate growth across various sectors within the state. The target beneficiaries of this grant program include county and local governments, community-based nonprofit organizations, and private sector nonprofit organizations that hold a 501(c)3 designation at the time of application. The program specifically excludes state agencies, school districts, charter schools, private schools, institutions of higher education, childcare facilities, churches, fire companies, fiscal agents, and for-profit organizations. The impact goals are broad, aiming for a holistic improvement in community health. The program prioritizes projects that involve preconstruction costs, land acquisition, building construction, reconstruction, rehabilitation, or restoration. It also supports the acquisition or installation of apparatus or equipment permanently attached to buildings, and the acquisition and improvement of land for project sites. Furthermore, the construction of sidewalks, sewers, or water mains connecting to public systems are eligible. These priorities demonstrate a focus on tangible, capital-intensive projects that build or restore essential community infrastructure. The expected outcomes and measurable results include the successful completion of capital projects that contribute to the economic, cultural, historical, and recreational health of Delaware communities. While specific metrics are not detailed, the emphasis on "redevelopment," "revitalization," and "investment" suggests a theory of change where targeted capital injections lead to observable improvements in community assets and overall quality of life. The program implicitly aims for a ripple effect, where improved infrastructure and facilities foster greater community engagement, economic activity, and cultural preservation.

This program provides funding to local nonprofit organizations in Charlottesville to support community development projects while fostering collaboration with University of Virginia student-athletes.

The OIA Technical Assistance Program 2025 provides funding for short-term projects that address immediate needs in U.S. insular areas, focusing on priorities like disaster response, climate change adaptation, and economic development, with awards ranging from $0 to $400,000.

To obtain a copy of the Funding Opportunity Announcement (FOA) please go to the ARPA-E website at https://arpa-e-foa.energy.gov. To apply to this FOA, Applicants must register with and submit application materials through ARPA-E eXCHANGE (https://arpa-e-foa.energy.gov/Registration.aspx). For detailed guidance on using ARPA-E eXCHANGE, please refer to the ARPA-E eXCHANGE User Guide (https://arpa-e-foa.energy.gov/Manuals.aspx). ARPA-E will not review or consider concept papers submitted through other means. For problems with ARPA-E eXCHANGE, email [email protected] (with FOA name and number in the subject line). Questions about this FOA? Check the Frequently Asked Questions available at http://arpa-e.energy.gov/faq. For questions that have not already been answered, email [email protected]. Agency Overview: The Advanced Research Projects Agency Energy (ARPA-E), an organization within the Department of Energy (DOE), is chartered by Congress in the America COMPETES Act of 2007 (P.L. 110-69), as amended by the America COMPETES Reauthorization Act of 2010 (P.L. 111-358), as further amended by the Energy Act of 2020 (P.L. 116-260) to: (A) to enhance the economic and energy security of the United States through the development of energy technologies that (i) reduce imports of energy from foreign sources; (ii) reduce energy-related emissions, including greenhouse gases; (iii) improve the energy efficiency of all economic sectors; (iv) provide transformative solutions to improve the management, clean-up, and disposal of radioactive waste and spent nuclear fuel; and (v) improve the resilience, reliability, and security of infrastructure to produce, deliver, and store energy; and (B) to ensure that the United States maintains a technological lead in developing and deploying advanced energy technologies. ARPA-E issues this Funding Opportunity Announcement (FOA) under its authorizing statute codified at 42 U.S.C. 16538. The FOA and any awards made under this FOA are subject to 2 C.F.R. Part 200 as supplemented by 2 C.F.R. Part 910. ARPA-E funds research on and the development of transformative science and technology solutions to address the energy and environmental missions of the Department. The agency focuses on technologies that can be meaningfully advanced with a modest investment over a defined period of time in order to catalyze the translation from scientific discovery to early-stage technology. For the latest news and information about ARPA-E, its programs and the research projects currently supported, see: http://arpa-e.energy.gov/. ARPA-E funds transformational research. Existing energy technologies generally progress on established learning curves where refinements to a technology and the economies of scale that accrue as manufacturing and distribution develop drive down the cost/performance metric in a gradual fashion. This continual improvement of a technology is important to its increased commercial deployment and is appropriately the focus of the private sector or the applied technology offices within DOE. By contrast, ARPA-E supports transformative research that has the potential to create fundamentally new learning curves. ARPA-E technology projects typically start with cost/performance estimates well above the level of an incumbent technology. Given the high risk inherent in these projects, many will fail to progress, but some may succeed in generating a new learning curve with a projected cost/performance metric that is significantly lower than that of the incumbent technology. ARPA-E funds technology with the potential to be disruptive in the marketplace. The mere creation of a new learning curve does not ensure market penetration. Rather, the ultimate value of a technology is determined by the marketplace, and impactful technologies ultimately become disruptive that is, they are widely adopted and displace existing technologies from the marketplace or create entirely new markets. ARPA-E understands that definitive proof of market disruption takes time, particularly for energy technologies. Therefore, ARPA-E funds the development of technologies that, if technically successful, have clear disruptive potential, e.g., by demonstrating capability for manufacturing at competitive cost and deployment at scale. ARPA-E funds applied research and development. The Office of Management and Budget defines applied research as an original investigation undertaken in order to acquire new knowledgedirected primarily towards a specific practical aim or objective and defines experimental development as creative and systematic work, drawing on knowledge gained from research and practical experience, which is directed at producing new products or processes or improving existing products or processes. (http://science.energy.gov/). Office of Science national scientific user facilities (http://science.energy.gov/user-facilities/) are open to all researchers, including ARPA-E Applicants and awardees. These facilities provide advanced tools of modern science including accelerators, colliders, supercomputers, light sources and neutron sources, as well as facilities for studying the nanoworld, the environment, and the atmosphere. Projects focused on early-stage R for the improvement of technology along defined roadmaps may be more appropriate for support through the DOE applied energy offices including: the Office of Energy Efficiency and Renewable Energy (http://www.eere.energy.gov/), the Office of Fossil Energy (http://fossil.energy.gov/), the Office of Nuclear Energy (http://www.energy.gov/ne/office-nuclear-energy), and the Office of Electricity Delivery and Energy Reliability (http://energy.gov/oe/office-electricity-delivery-and-energy-reliability). Applicants interested in receiving financial assistance for basic research (defined by the Office of Management and Budget as experimental or theoretical work undertaken primarily to acquire new knowledge of the underlying foundations of phenomena and observable facts) should contact the DOEs Office of Science (http://science.energy.gov/). Office of Science national scientific user facilities (http://science.energy.gov/user-facilities/) are open to all researchers, including ARPA-E Applicants and awardees. These facilities provide advanced tools of modern science including accelerators, colliders, supercomputers, light sources and neutron sources, as well as facilities for studying the nanoworld, the environment, and the atmosphere. Projects focused on early-stage R for the improvement of technology along defined roadmaps may be more appropriate for support through the DOE applied energy offices including: the Office of Energy Efficiency and Renewable Energy (http://www.eere.energy.gov/), the Office of Fossil Energy (http://fossil.energy.gov/), the Office of Nuclear Energy (http://www.energy.gov/ne/office-nuclear-energy), and the Office of Electricity Delivery and Energy Reliability (http://energy.gov/oe/office-electricity-delivery-and-energy-reliability). Program Overview: The Creating Hardened And Durable fusion first Wall Incorporating Centralized Knowledge (CHADWICK) program will pursue discovery and testing of novel, first-wall materials that will maintain design performance over the target 40-year design lifetime of a fusion power plant. In most fusion power systems, the fusion reactions are physically contained by the first wall. The first wall bears the mechanical load and protects the components from the extreme heat and highly energetic charged and neutral particles. The safety and structural performance of the first wall are compromised over time by significant exposure to high-energy (;gt;1 million electron volts (MeV)) neutrons and heat flux as much as 10 megawatts per square meter (MW/m2)). As fusion energy advances towards commercial deployment, the lifetime and maintainability of first-wall materials will become a major challenge for the commercial viability of fusion power plants with high neutron flux. Thermal effects on materials are relatively well understood. However, the combination of heat plus an intense neutron environment can generate many nonlinear effects that are difficult to predict. Radiation most commonly damages a material by driving atomic displacements and the transmuting of isotopes within the material structure. Some transmutation events encourage the development of activation product gasses, such as hydrogen and helium, which encourage wall swelling. The combination of stresses caused by atomic dislocations, swelling, and thermal contraction and expansion drive material hardening and embrittlement, ultimately promoting premature cracking and failure. The most common descriptor for radiation damage is displacements per atom (dpa). These displacements can cause irradiation embrittlement leading to the loss of ductility in a material after exposure to radiation. Fusion power plant first-wall materials are anticipated to experience ;gt;50 dpa over the desired 40-year operational period. Radiation damage has been observed to harden and embrittle first-wall materials at levels as low as 5 dpa. The goal of the CHADWICK program is the discovery, development, and production of new materials that can maintain the following metrics in a fusion first-wall environment: Room temperature ductility after 50 dpa of irradiation damage and helium generation; Sufficiently high thermal conductivity to remove up to 10 MW/m2 of heat; Activation below 10,000 Sieverts per hour (Sv/hr) to enable remote handling; Swelling below 1% to maintain dimensional stability; and Tritium retention and plasma erosion lower than current state-of-the-art (SoA) materials. SoA materials under consideration for fusion first-wall applications are currently limited to reduced activation ferritic martensitic (RAFM) steels and tungsten.7 Both materials suffer from irradiation and helium embrittlement issues that make fusion power plants prohibitively expensive to qualify and operate. New materials that are highly resistant or functionally immune to irradiation embrittlement up to 50 dpa can increase the lifetime of the first wall by a factor of 10. These materials are envisioned to be essential to the deployment of sustained and economical fusion energy. To view the FOA in its entirety, please visit https://arpa-e-foa.energy.gov.

The Edgecombe Charitable Foundation offers community grants to qualified charitable organizations serving Edgecombe County, North Carolina. This program aligns with the foundation's mission to address a broad range of local needs, supporting initiatives in human services, education, youth development, health, food/nutrition, arts, and other community-benefiting areas. The foundation's strategic priority is to foster the well-being and development of the local community by providing crucial funding for diverse programs. The target beneficiaries for these grants include a wide array of community members served by eligible organizations. The impact goals are to support and enhance essential services and programs that improve the quality of life within Edgecombe County. The foundation focuses on tangible community benefits, aiming for outcomes such as improved access to education, better health outcomes, enhanced youth development opportunities, and increased access to food and nutritional resources. The priorities for funding include 501(c)(3) public charity nonprofit organizations, organizations with a fiscal agent who is a 501(c)(3) public charity, local governments (including public schools), and fire and rescue departments. Religious entities can also apply for social outreach and charitable service programs, but not for general operating support. Organizations must serve the counties within the affiliate network and offer programs without discrimination. Grants typically range from $500 to $5,000, with a maximum of $10,000 for an "Impact Grant" for a single organization. The expected outcomes include the successful implementation of programs that meet identified community needs and contribute to the overall betterment of Edgecombe County. Measurable results would be tied to the specific objectives of each funded project, such as the number of individuals served, improvements in specific health indicators, educational attainment, or participation in arts and cultural programs. The foundation's theory of change is that by strategically investing in diverse community-serving organizations, it can create a lasting positive impact on the lives of residents and the overall health of the community.

The EQT Foundation Grant program is designed to support nonprofits that demonstrate positive, needed, and trusted impacts within their communities. The foundation is deeply committed to fostering education and training for both children and adults, developing diverse and livable communities, and preserving natural environments. This mission aligns with their belief in meaningful community engagement and responsible corporate citizenship, emphasizing trust-based philanthropy to ensure resources directly contribute to community stability and, in turn, support successful business operations in their operational footprint. The foundation's funding strategy prioritizes organizations and programs that directly impact community residents. They seek proposals grounded in analysis that demonstrate creative approaches to addressing critical issues. The target beneficiaries include children and adults receiving education and training, residents of diverse and livable communities, and those benefiting from natural environment preservation efforts. The impact goals revolve around creating positive and needed change, fostering community stability, and contributing to the overall well-being of the areas where EQT Corporation operates. The EQT Foundation focuses on three core areas: Community Enrichment, Education & Workforce, and Environment. Community Enrichment encourages the development of diverse, safe, healthy, and sustainable communities, with examples ranging from food banks and libraries to arts programs and community festivals. Education & Workforce aims to promote STEM proficiency for youth and create a skilled future workforce through initiatives like in-school STEM curricula, computer camps, and career planning. The Environment focus supports natural resource preservation and educates communities on conservation techniques, including community gardens, watershed conservation, and green space restoration. Beyond these thematic priorities, the EQT Foundation also seeks evidence of a geographic setting that aligns with EQT Corporation’s business locations, effective management of available resources, and outreach that garners solid public recognition and support for the nonprofit, its programs, and sponsors. While specific expected outcomes and measurable results are not detailed, the emphasis on "positive, needed, and trusted impacts" and "creative approaches to addressing critical issues" suggests a commitment to tangible community benefits. The foundation's theory of change appears to be that by strategically investing in education, community development, and environmental preservation in their operational areas, they contribute to the long-term stability and success of these communities, which in turn supports their business operations.

This funding opportunity provides financial support to nonprofit organizations in Massachusetts for reentry programs aimed at helping young adults transition successfully from incarceration to the community, thereby reducing recidivism and enhancing public safety.

The Wyoming Women's Foundation (WYWF) is currently accepting applications for its 2024 Grant cycle, with a deadline of May 15, 2024. This grant program is meticulously designed to align with the foundation's core mission: investing in the economic self-sufficiency of women and creating opportunities for girls within Wyoming. The foundation's strategic priority is to address systemic barriers and foster an environment where women and girls can thrive economically. The primary target beneficiaries of this grant program are women and girls residing in Wyoming, across all counties. The overarching impact goal is to enhance their long-term economic self-sufficiency. This is achieved by focusing on programs that help women meet or exceed the Wyoming Self-Sufficiency Standard for their family composition and county, as well as developing opportunities for girls. The WYWF grant program has three key funding priorities. The first is Income and Asset Development, which supports projects like education and job training for higher wages, and asset-building initiatives such as first-home purchases, business development, and retirement savings. The second priority is Mentoring and Leadership, funding programs that boost confidence and create meaningful connections for women and girls, including leadership training, mentoring programs, career development, and STEM programming. The third priority is Systems Change, which aims to address barriers to economic self-sufficiency and the gender wage gap through advocacy and education, such as wage negotiation training and awareness campaigns. Expected outcomes and measurable results include an increase in the number of women living at or above the Wyoming Self-Sufficiency Standard, improved leadership skills and confidence among women and girls, and a reduction in the gender wage gap in Wyoming through systemic changes. The foundation's theory of change posits that by investing in these targeted areas—income and asset development, mentoring and leadership, and systems change—it can directly contribute to the economic empowerment of women and girls, fostering a more equitable and prosperous future for the state. Eligibility criteria stipulate that applicants must have 501(c)(3) tax-exempt status or a sponsoring agency, and the requested grants must explicitly promote the long-term economic self-sufficiency of women and opportunities for girls in Wyoming, addressing at least one of the WYWF granting priorities.

The Chilkat Valley Community Foundation (CVCF), an affiliate of The Alaska Community Foundation (ACF), is offering grants to qualified, tax-exempt 501(c)(3) organizations (or equivalents like Tribal entities, schools, and faith-based organizations) that support charitable programs in the Chilkat Valley area. This grant program aligns with the foundation's mission to address a broad range of community needs. Grants are available in three categories: Operating Support, New Program and Special Project, and Capital Grants. The typical grant awards range from $500-$3,500, with an overall grant size ranging from $1,000 to $10,000. The target beneficiaries are organizations serving the Chilkat Valley, with an emphasis on local, sustainable organizations for operating support, and those undertaking new or special projects. The impact goals are to support various community needs including health and wellness, education, the great outdoors, arts and culture, and community development. Capital grants are also available for construction, remodel, renovation, technology, furniture, and equipment, aiming to enhance the infrastructure and resources of community organizations. The program prioritizes organizations that are tax-exempt 501(c)(3) or equivalent. Capital Grant applicants receive extra scoring points if they have previously applied for other grants for the same project. Ineligible organizations include individuals, for-profits, specific non-profits (501(c)(4), 501(c)(6)), non-Alaska based organizations, private foundations, government agencies, and ad hoc groups. Activities such as religious indoctrination, endowment building, fundraising, lobbying, and political activities are also ineligible. Exceptions are made for faith-based organizations or governmental units whose proposals broadly benefit the community, and ineligible organizations can apply through fiscal sponsorship. Expected outcomes include the completion of grant projects within one year of the award, subject to the grantee completing an online grant agreement. The measurable results are tied to the successful implementation of supported programs and projects, contributing to the health, education, cultural enrichment, environmental preservation, and overall development of the Chilkat Valley. The foundation's strategic priority is to foster a vibrant community by supporting a diverse array of charitable initiatives, operating under the theory that targeted financial assistance to qualifying organizations will lead to improved community well-being and sustained local development.

This program provides funding for community-led initiatives in Phoenix that focus on improving neighborhood safety and security through block watch projects.

The Avery Community Foundation (ACF) is offering community grants to qualified charitable organizations serving Avery County, North Carolina. This grant program aligns with the foundation's mission to address a broad range of local needs. The ACF seeks to support initiatives that strengthen the community across various sectors, demonstrating a strategic commitment to comprehensive local development. The grant program targets a diverse range of beneficiaries within Avery County, including those in need of human services, education, youth development, health, food/nutrition, and arts. The impact goal is to meet these local needs through funding programs that deliver direct benefits to the community-at-large. The foundation prioritizes organizations that provide programs and services without discrimination based on age, race, national origin, ethnicity, gender, physical ability, sexual orientation, political affiliation, or religious belief. The program focuses on supporting 501(c)(3) public charity nonprofit organizations, organizations with a fiscal agent who is a 501(c)(3) public charity, local governments (including public schools), and fire and rescue departments. Religious entities may also apply for funding to support social outreach and charitable service programs that benefit the community-at-large, but not for general operating support. This focus ensures that funding reaches a wide array of entities capable of implementing effective community programs. While specific measurable results are not explicitly detailed beyond meeting local needs, the foundation expects outcomes that demonstrably improve the quality of life and address the identified challenges within Avery County. The typical grant range of $500 to $1,000 suggests a strategy of providing smaller, impactful grants to support numerous local initiatives. The ACF's theory of change appears to be rooted in empowering local organizations to directly address community needs, thereby fostering a more resilient and thriving local environment.

This grant provides financial support to organizations in Rhode Island for activities that enhance their operational effectiveness, including strategic planning and anti-racism training, with a focus on those with smaller budgets or addressing critical needs.

This funding opportunity provides $125,000 to organizations that will create a STEM learning lab for Indian students aged 13 to 21, promoting innovative education and future partnerships with U.S. institutions.

This funding opportunity supports research projects that promote innovation and development in North Carolina's agricultural economy, targeting universities, non-profits, and businesses involved in agriculture.

This notice is not a mechanism to fund existing NOAA awards. The purpose of this notice is to request applications for special projects and programs associated with NOAA's strategic plan and mission goals, as well as to provide the general public with information and guidelines on how NOAA will select applications and administer discretionary Federal assistance under this Broad Agency Announcement (BAA).This Broad Agency Announcement is a mechanism to encourage research, education and outreach, innovative projects, or sponsorships that are not addressed through NOAA’s competitive discretionary programs. This announcement is not soliciting goods or services for the direct benefit of NOAA. Funding for activities described in this notice is contingent upon the availability of Fiscal Year 2021, Fiscal Year 2022, and Fiscal Year 2023 appropriations. Applicants are hereby given notice that funds have not yet been appropriated for any activities described in this notice. Publication of this announcement does not oblige NOAA to review an application beyond an initial administrative review, or to award any specific project, or to obligate any available funds. As an agency with responsibilities for maintaining and improving the viability of marine and coastal ecosystems, for delivering valuable weather, climate, and water information and services, for understanding the science and consequences of climate change, and for supporting the global commerce and transportation upon which we all depend, NOAA must remain current and responsive in an ever-changing world. We do this in concert with our partners and stakeholders in Federal, state, and local governments and private organizations, applying a systematic approach that links our strategic goals through multi-year plans to the daily activities of our employees. Every year we are committed to re-evaluate our progress and priorities, look for efficiencies, and take advantage of new opportunities to improve our information, products, and services. In furtherance of this objective, NOAA issues this BAA for extramural research, innovative projects, and sponsorships (e.g., conferences, newsletters, etc.) that address one or more of the following four mission goal descriptions contained in the NOAA Strategic Plan: Climate Adaptation and Mitigation Weather-Ready Nation Healthy Oceans Resilient Coastal Communities and Economies