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Grants for Small businesses - Federal

Explore 1,527 grant opportunities

Strengthening national laboratory and HIV epidemiologic monitoring capacities and systems to enhance an efficient, resilient and self-reliant response to HIV, TB and related public health threats in the Kingdom of Eswatini under PEPFAR
$5,000,000
U.S. Department of Health and Human Services (Centers for Disease Control-GHC)
Federal

Application Deadline

Feb 17, 2026

Date Added

Oct 17, 2025

This grant provides funding to strengthen laboratory and disease monitoring systems in Eswatini, enhancing the country's ability to effectively respond to HIV, tuberculosis, and other public health threats.

Health
State governments
Leveraging Nursing Research to Advance Healthy School Environments for All
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Apr 27, 2026

Date Added

May 29, 2025

This funding opportunity supports a variety of organizations in conducting research to improve health and educational outcomes for youth by creating healthier school environments.

Health
State governments
Assay Validation of High Quality Markers for Clinical Studies in Cancer (UH3 Clinical Trials Not Allowed)
$250,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Oct 14, 2026

Date Added

Oct 16, 2024

Assay Validation of High Quality Markers for Clinical Studies in Cancer (UH3 Clinical Trials Not Allowed) aims to support the clinical validation of already analytically validated biomarkers and assays for cancer detection, diagnosis, and treatment monitoring, ensuring they are reliable and ready for use in clinical studies without conducting new trials.

Education
State governments
FY 2024 2026 Broad Agency Announcement (BAA), National Marine Fisheries Service
Contact for amount
U.S. Department of Commerce (DOC NOAA - ERA Production)
Federal

Application Deadline

Sep 30, 2026

Date Added

Jul 30, 2024

This funding opportunity supports innovative projects and research aimed at sustainable fisheries management, protected species recovery, and marine ecosystem enhancement, targeting a wide range of applicants including educational institutions, nonprofits, and government entities.

Environment
State governments
Information Innovation Office (I2O) Office-Wide
Contact for amount
U.S. Department of Defense (DARPA - Information Innovation Office)
Federal

Application Deadline

Nov 30, 2026

Date Added

Dec 1, 2025

This funding opportunity invites innovative research proposals from a wide range of organizations, including universities and small businesses, to develop groundbreaking technologies in information and computational science that enhance national security.

Science and Technology
For profit organizations other than small businesses
Genetic Medicines And Individualized Manufacturing For Everyone (GIVE)
Contact for amount
U.S. Department of Health and Human Services
Federal

Application Deadline

Feb 27, 2026

Date Added

Sep 29, 2025

This program provides funding to a wide range of organizations, including nonprofits, universities, and businesses, to develop innovative solutions for producing personalized genetic medicines quickly and efficiently, improving patient access across the United States.

Health
For profit organizations other than small businesses
ROSES25: B.6 Heliophysics Technology and Instrument Development for Science
$2,350,000
National Aeronautics and Space Administration (NASA Headquarters)
Federal

Application Deadline

Apr 15, 2026

Date Added

Jan 13, 2026

This grant provides funding for universities and nonprofits to develop innovative technologies and instruments that advance research in solar and space physics, supporting NASA's goals for future space exploration.

Science and Technology
Public and State controlled institutions of higher education
NIGMS National and Regional Resources (R24 - Clinical Trial Not Allowed) PAR-25-416
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jun 14, 2027

Date Added

May 14, 2025

This funding opportunity supports the development and maintenance of shared biomedical research resources that provide advanced technologies and services to researchers across multiple states or nationally, ensuring broad access for academic investigators.

Science and Technology
State governments
Animal and Biological Material Resource Centers (P40 Clinical Trial Not Allowed)
$650,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Feb 18, 2026

Date Added

Jun 10, 2025

This funding opportunity provides support for specialized research centers that develop and maintain laboratory animal colonies and biological materials, promoting scientific rigor and accessibility for researchers across the U.S.

Health
State governments
Accelerating the Pace of Substance Use Research Using Existing Data (R01 Clinical Trial Not Allowed)
$4,000,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jul 17, 2026

Date Added

Dec 6, 2024

This funding opportunity supports researchers in utilizing existing datasets to advance the understanding of substance use behaviors and related health issues, particularly focusing on critical health disparities and innovative analytical approaches.

Health
Public and State controlled institutions of higher education
Fundamental Research to Counter Weapons of Mass Destruction
$2,500,000
U.S. Department of Defense (Defense Threat Reduction Agency)
Federal

Application Deadline

Sep 30, 2034

Date Added

Oct 2, 2024

This funding opportunity supports innovative research to develop strategies and technologies for countering threats from weapons of mass destruction, targeting a wide range of applicants including universities, nonprofits, and businesses.

Science and Technology
Public and State controlled institutions of higher education
Injury Prevention and Control Research and State and Community Based Programs - RFA-GH-18-000
Contact for amount
U.S. Department of Health and Human Services (Centers for Disease Control and Prevention - ERA)
Federal

Application Deadline

Sep 30, 2030

Date Added

Oct 13, 2023

This funding opportunity provides financial support to a wide range of organizations, including state governments, universities, and non-profits, to develop and implement innovative programs focused on preventing and controlling injuries at the community level across the United States.

Health
County governments
Rfa-Cc-18-000
Contact for amount
U.S. Department of Health and Human Services (Centers for Disease Control and Prevention - ERA)
Federal

Application Deadline

Sep 30, 2030

Date Added

Nov 26, 2025

This funding opportunity provides financial support to a wide range of organizations, including states, universities, and nonprofits, to implement evidence-based initiatives aimed at preventing injuries and improving public health outcomes.

Health
State governments
DOE Industrial Training & Assessment Centers (ITAC) Implementation Grants
$300,000
U.S. Department of Energy
Federal
Rolling

Application Deadline

Not specified

Date Added

Oct 3, 2024

This program provides funding to small and medium-sized manufacturing companies and water/wastewater treatment facilities to implement energy efficiency improvements and reduce emissions, while also creating job opportunities in disadvantaged communities.

Energy
Small businesses
Arctic Research Opportunities
$50,000,000
National Science Foundation
Federal

Application Deadline

Jul 15, 2026

Date Added

May 21, 2025

This funding opportunity provides financial support for U.S.-based researchers to study the Arctic's environment and communities, with a focus on collaboration with Indigenous peoples and advancing understanding of Arctic change and its global impacts.

Science and Technology
Public and State controlled institutions of higher education
NCI Pathway to Independence Award (K99/R00 Clinical Trial Not Allowed)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Oct 14, 2027

Date Added

Nov 21, 2024

This grant provides financial support to promising postdoctoral researchers in cancer-related fields, helping them transition to independent faculty positions through a structured mentorship and research development program.

Education
State governments
ancient DNA for Modern Genomics (aDMG) Coordination Center
$1,500,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Mar 2, 2026

Date Added

Jul 16, 2025

This funding opportunity provides financial support for a centralized coordination center that will ethically manage and enhance research on ancient human DNA, fostering collaboration among diverse scientific and community stakeholders.

Health
State governments
Stimulate Utilization of Plentiful Energy in Rocks through High-temperature Original Technologies (SUPERHOT)
$10,000,000
U.S. Department of Energy (Advanced Research Projects Agency Energy )
Federal

Application Deadline

Mar 5, 2026

Date Added

Jan 29, 2026

This funding opportunity supports innovative research and development of geothermal energy technologies to harness superhot underground resources, targeting researchers, companies, and institutions focused on advancing energy solutions.

Opportunity Zone Benefits
Individuals
Mechanisms that Impact Cancer Risk after Bariatric Surgery (R01 Clinical Trial Optional)
$500,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jan 7, 2028

Date Added

Sep 6, 2024

This funding opportunity supports researchers investigating how bariatric surgery influences cancer risk through biological mechanisms, encouraging studies that go beyond weight loss to explore long-term health effects.

Education
State governments
NCATS Translational Science Education and Training Challenge
$10,000
U.S. Department of Health and Human Services (National Center for Advancing Translational Sciences)
Federal

Application Deadline

Apr 30, 2026

Date Added

Dec 24, 2025

This initiative provides cash prizes to U.S.-based educational programs that effectively train diverse individuals in translational science, helping to accelerate the development of health solutions.

Education
Individuals