Federal Health Grants

The "Materials to Enhance Training in Experimental Rigor (METER)" grant aims to support the creation of innovative educational materials for an online platform, designed to improve understanding and application of rigorous biomedical research principles among researchers and scientists at different career stages.

This funding opportunity supports research projects that investigate individual differences in pain experiences and treatment responses, aiming to develop personalized pain management strategies while addressing the opioid crisis.

The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The over-arching goal of this R25 program is to support educational activities that foster a better understanding of biomedical, behavioral and clinical research and its implications. To accomplish the stated over-arching goal, this FOA will support creative educational activities with a primary focus on research experiences for high school or undergraduate students or science teachers during the summer academic break. The proposed program needs to fit within the mission of the participating IC that the application is being submitted to and should not have a general STEM focus (see below and Table of IC-Specific Information and Points of Contact).

This program provides funding to early-career medical and dental professionals to help them start research careers focused on aging and geriatric health.

This funding opportunity supports U.S.-based organizations in evaluating the impact of upcoming public policies and programs that aim to improve health behaviors and reduce chronic disease risk factors through behavioral changes.

U.S. Embassy Nigeria through the U.S. Presidents Emergency Plan for AIDS Relief (PEPFAR) Coordination Office of the Bureau of Global Health Security and Diplomacy at the U.S. Department of State announces an open competitive opportunity for organizations to apply for funding to implement community-led monitoring or a virtual spaces intervention among priority populations for HIV prevention and treatment, including Key Populations (KP) and Adolescent and Young People (AYP). For HIV to no longer be a public health threat by 2030 in Nigeria, the populations at highest risk must know their HIV status, receive lifesaving HIV prevention and treatment, and reach viral suppression if they are HIV-positive. Data show that HIV prevention and treatment efforts should be focused on AYP and KPs. Key Populations include men who have sex with men, transgender individuals, sex workers, people who inject drugs (PWID), and people in prisons and other closed settings. Under this opportunity, the PEPFAR Coordination Office seeks to address pillar 1 of the 5x3 strategy, health equity for priority populations. Youth make up a significant proportion of the more than 32.9 million Nigerians reported to be active users of social media. AYP-led CSOs in the country have identified a gap with the lack of structured sexual health and HIV messaging and interventions on these platforms. Virtual online space is a digital environment that enables people to, socialize, interact, and gather information using available technologies and non-necessarily requiring a physical space to operate. Interventions on a virtual space may include, but not be limited to phone services such as calls and messaging, mobile applications, websites, and social media channels. Through Virtual Spaces Interventions, PEPFAR Nigeria intends to address the gaps in the use of online platforms and spaces by meeting KP and AYP where they are; providing them with HIV and other relevant health information; facilitating referrals and linkages to health facilities for person-centered HIV prevention, treatment, and other health care services. Prioritizing these spaces as a compliment of existing health systems in the on-going efforts to increase program reach among AYP and KPs, and to use this space to facilitate health promotion, HIV testing and case-finding, and drive access to other health services in a confidential manner. This program seeks to increase access to quality, concise and accurate HIV and health related messaging, facilitate active referrals and linkages to spaces and locations which can provided access to strategic HIV and other health services for prevention, treatment and care interventions targeted at AYP and KPs by leveraging on virtual spaces utilized by adolescents and young persons. The program will support community-led monitoring efforts among AYP and KP-led groups using platforms such as iMonitor + to ensure that HIV positive individuals among these priority populations are receiving high quality care and treatment services, identify any challenges, barriers, and/or gaps to care, and to report findings to PEPFAR to inform service delivery.

This funding opportunity supports researchers conducting time-sensitive studies that enhance ongoing clinical projects related to arthritis, musculoskeletal, and skin diseases, aiming to improve understanding and treatment of these conditions.

This Notice of Funding Opportunity (NOFO) announces the opportunity to apply for funding under the Health Center Programs Service Area Competition (SAC). The purpose of this funding is to ensure continuity of care in the communities and populations currently served by the Health Center Program. See Program Requirements and Expectations for more details.

The purpose of this program is to support Community-Led Monitoring of HIV services at selected health service sites to promote improvements in the HIV response under the Presidents Emergency Plan for AIDS Relief (PEPFAR).Community-led monitoring (CLM) is a technique initiated and implemented by local community-based organizations and other civil society groups, networks of key populations (KP), people living with HIV (PLHIV), and other affected groups or other community entities that gathers quantitative and qualitative data about HIV services. The focus is on getting input from recipients of HIV services, especially key populations and underserved groups, in a routine and systematic manner that will translate into action and change. CLM is central to PEPFAR’s client-centered approach because it helps puts communities, their needs, and their voices at the center of the HIV response. Why does PEPFAR support Community-Led Monitoring? CLM conducted by local civil society organizations helps PEPFAR programs and health institutions diagnose and pinpoint persistent problems, challenges, and barriers related to HIV service access, uptake, and retention at the community and facility level. CLM aims to improve HIV service delivery and client outcomes by identifying data-driven solutions to overcome barriers and ensure beneficiaries receive optimal client-centered HIV services in a manner that is productive, collaborative, respectful, and solutions-oriented. Who does PEPFAR fund for CLM? PEPFAR-supported CLM is conducted objectively by independent, local community organizations. PEPFAR implementing partners who currently work on service delivery at the site level are not eligible for CLM funding, even if they will sub-grant to a local civil society organization. What is monitored and how? Systematic and routine, with follow up and continuous improvement. Tailored to the needs identified by local communities, with communities directly determining the scope. Allow for community and host country government development of the specific metrics, measures, or tools to be used for CLM. Metrics or measures should be tailored to a given context and address the specific needs and concerns of community members. Triangulated with, but not duplicative of, other PEPFAR data streams. Community-led monitoring data should reflect an ‘added value’ and not duplicate collection of routine data already available to PEPFAR. ‘Added value’ monitoring data includes: information from beneficiaries about their experience with the health facility, information about barriers and enablers to access and retention in services, etc. Productive, collaborative, respectful, and solutions-oriented. Action-oriented with an associated follow-up process with the health facility that is overseen by U.S. government staff, committed to corrective public health action, and involves community advocacy to improve service outcomes

This grant provides funding for collaborative research projects that investigate how RNA modifications influence cancer development by altering protein synthesis, requiring expertise in RNA biology and cancer research.

This funding opportunity supports innovative research to develop combination cancer therapies that integrate radiation treatment with targeted molecular agents, aimed at improving treatment effectiveness while reducing side effects.

This funding opportunity supports the establishment of Clinical Coordinating Centers for multi-site clinical trials focused on heart, lung, and blood health issues, encouraging collaboration and community engagement to improve trial efficiency and address health disparities.

The purpose of this Negotiation Cooperative Agreement is to provide Tribes with resources to help defray the costs associated with preparing for and engaging in TSGP negotiations. TSGP negotiations are a dynamic, evolving, and tribally driven process that requires careful planning, preparation, and sharing of precise, up-to-date information by both Tribal and Federal parties. Because each Tribal situation is unique, a Tribes successful transition into the TSGP, or expansion of their current program, requires focused discussions between the Federal and Tribal negotiation teams about the Tribes specific health care concerns and plans. One of the hallmarks of the TSGP is the collaborative nature of the negotiations process, which is designed to: 1) enable a Tribe to set its own priorities when assuming responsibility for IHS PSFAs; 2) observe and respect the government-to-government relationship between the U.S. and each Tribe; and 3) involve the active participation of both Tribal and IHS representatives, including the OTSG. Negotiations are a method of determining and agreeing upon the terms and provisions of a Tribes Compact and FA, the implementation documents required for the Tribe to enter into the TSGP. The Compact sets forth the general terms of the government-to-government relationship between the Tribe and the Secretary of the U.S. Department of Health and Human Services (HHS). The FA: 1) describes the length of the agreement (whether it will be annual or multi-year); 2) identifies the PSFAs, or portions thereof, the Tribe will assume; 3) specifies the amount of funding associated with the Tribal assumption; and 4) includes terms required by Federal statutes and other terms agreed to by the parties. Both documents are required to participate in the TSGP and they are mutually negotiated agreements that become legally binding and mutually enforceable after both parties sign the documents. Either document can be renegotiated at the request of the Tribe.

The purpose of this Notice of Funding Opportunity (NOFO) is to support formative research and pilot testing of culturally sensitive, innovative interventions to identify and mitigate the risk of suicidal ideation and behavior (SIB), and/or non-suicidal self-injury (NSSI) in Low- and Middle-Income Countries (LMICs). The proposed research initiatives must incorporate a plan to strengthen research capacity within the LMIC community where the study will be conducted.

This funding opportunity supports the Coriell Institute in maintaining and expanding a repository of high-quality human cell lines and DNA samples for biomedical research, benefiting scientists studying genetic disorders and human health.

This grant provides funding for researchers, especially those new to the field or looking to integrate advanced data science methods, to explore addiction-related questions using existing data and innovative analytical techniques.

This funding opportunity supports U.S.-based researchers and organizations in developing non-addictive pain relief therapies to combat the opioid crisis, with a focus on advancing preclinical candidates toward clinical trials.

Enhances the integration of HIV-related services and primary healthcare in select countries that are at or near HIV epidemic control to sustain gains made by PEPFAR and contribute to resilient public health systems. The United States President's Emergency Plan for AIDS Relief (PEPFAR) is a US governmental initiative to address the global HIV/AIDS epidemic. To ensure longevity and sustainability in areas with low HIV prevalence, HIV treatment can be incorporated into existing successful primary health care models with decentralised service delivery to promote adherence to long-term treatment.18 With support from the United States Agency for International Development (USAID) and other international partners, Haiti has had integrated HIV and primary health-care services for over 20 years.19, 20 The PEPFAR programme in Haiti integrates HIV, maternal and child health care, and family planning services in primary health-care settings to reduce HIV stigma. At the site level, Haitians who receive maternal and child health care and family planning services also obtain HIV education and screening, as well as STI education and treatment. At the community level, Haiti provides integrated HIV self-testing, postnatal visits, immunisations, referral services, adherence counselling, and tracking of treatment interruptions. HIV services are also being integrated into the scope of work for community health workers.21 Efforts to make HIV treatment more sustainable include gradual transition of donor-paid health worker salaries to the national budget.

The FY 2024 Strategic Prevention Framework-Partnerships for Success (SPF-PFS) for States funding opportunity, managed by SAMHSA’s Center for Substance Abuse Prevention, is designed to assist states in building prevention capacities to reduce substance misuse and related behavioral health issues. This program specifically targets communities facing high risks of substance misuse by supporting the development and delivery of evidence-based, data-driven prevention services at the state and community levels. By leveraging the Strategic Prevention Framework (SPF), this initiative prioritizes underage drinking, opioid misuse, and other substance use concerns. The funding emphasizes the involvement of underserved communities, which includes racial, ethnic, and geographic groups systematically denied access to necessary resources and services. Eligible applicants are U.S. states, territories, Pacific jurisdictions, and the District of Columbia. The funding opportunity is not open to entities that have previously received SPF-PFS funds under specific past awards to avoid redundancy in funding. For FY 2024, SAMHSA will distribute a total of $15.5 million across approximately 12 awards, with each award offering up to $1.25 million annually over a five-year period, contingent on available appropriations. Applications are due by February 21, 2024, with anticipated project start dates of September 30, 2024. Required activities include assessing community needs, building partnerships, collecting and analyzing data, and implementing community-level health assessments. States are expected to create a statewide community health improvement plan that aligns with prevention priorities identified through these assessments. At least 60% of each award must be directed to subrecipient communities that demonstrate a need for programming in chosen priority areas. The SPF process involves five main steps—assessment, capacity building, planning, implementation, and evaluation—plus guiding principles of cultural competence and sustainability. States must ensure coordination with other community-based recipients of SPF-PFS funding and leverage partnerships with the Prevention Technology Transfer Center for technical support. Applications must include a project narrative limited to 10 pages, detailing the project’s goals, objectives, required activities, and a budget justification. SAMHSA requires a dedicated Project Director and Data Analyst with specific time commitments. A letter to the Single State Agency, confidentiality protocols, and biographical sketches are also required. Bonus points are available for applicants demonstrating a focus on underserved populations, making up at least 50% of the population served. Data collection will follow the Government Performance and Results Modernization Act, with performance data submitted quarterly via SAMHSA’s reporting system (SPARS). Evaluation criteria for the grant include feasibility, organizational capacity, project alignment with program goals, cost-effectiveness, and commitment to behavioral health equity. Applicants must provide documentation of their efforts to identify and address health disparities in the populations served. Grant recipients must report on performance quarterly and annually, including progress in underserved communities and efforts to reduce behavioral health disparities.

This funding opportunity supports researchers developing and testing strategies to prevent fetal alcohol spectrum disorders and improve interventions for affected individuals throughout their lives.