Grants for County governments - Health

This grant provides funding for research projects that investigate how environmental factors, such as toxins and pathogens, impact the mechanisms and outcomes of Alzheimer's Disease-Related Dementia through interactions at biological interfaces in the human body.

This funding opportunity provides financial support for early-stage researchers in the U.S. to explore innovative studies on HIV-related health issues, such as comorbidities and coinfections, with the potential to transform understanding and treatment in this field.

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The Red Coats' Community Grants program is designed to fund smaller projects for nonprofit organizations in Northeast Florida, specifically in Baker, Clay, Duval, Nassau, and St. Johns counties. This program aligns with the Red Coats' mission, which involves a group of civic and corporate leaders overseeing THE PLAYERS volunteer efforts and a special grant program for local nonprofits. The grants are intended to support community needs within this five-county area, with individual awards of up to $15,000. The target beneficiaries of this program are citizens within the five-county area, served by eligible nonprofit organizations. The program aims to address specific community needs and provide services aligned with priority focus areas. These areas include youth services, education, character development, health, wellness and sports, and military support. The overarching impact goal is to foster broad community support and create positive change in these key sectors. The Red Coats prioritize funding organizations that demonstrate broad community support and actively address identified community needs. A crucial focus is on ensuring services are provided without discrimination, as protected by law. The program specifically excludes funding for individuals, private foundations, grant-making bodies, operational expenses (including salaries), travel or conference expenses, sponsorships with tangible staff benefits, political action committees, political causes or candidates, debt reduction, and gifts, honorariums, or gratuities. The expected outcomes of the grant program are to strengthen nonprofit organizations' capacity to deliver vital services in the priority areas. Measurable results would be tied to the specific projects funded, such as improved educational outcomes for youth, enhanced health and wellness initiatives, or increased support for military families. The foundation's strategic priorities are evident in its focus on local community development through targeted support in these key areas, leveraging the involvement of civic and corporate leaders to achieve its philanthropic goals.

The purpose of this initiative is to advance research that reduces firearm injury and disparities through the development and evaluation of firearm injury primary prevention interventions leveraging community healthcare settings. This funding opportunity solicits applications that focus on primary prevention of firearm injury leveraging community healthcare settings. Applications may propose intervention studies with a rigorous design including, but not limited to, policy implementation studies, natural experiments and other studies with a quasi-experimental design, as well as those meeting the NIH definition of a clinical trial. Aims may focus on efficacy, effectiveness, or hybrid effectiveness/implementation research. Health or behavioral outcomes for this funding opportunity should be appropriate to the aims and should include, but are not limited to, changes in behavior related to firearm injury prevention and firearm safety procedures, and implementation outcomes. Change in knowledge of firearm injury prevention measures may be a secondary outcome (e.g., as a mechanism of action) but should not be the focus of the project. Multi-level, multi-disciplinary interventions and outcomes are encouraged, including individual, interpersonal, organizational, and community levels. Individual level outcomes should be one of the outcome levels included. Rigorous methods that address potential sources of bias that are appropriate to the study design are expected. Intervention studies are expected to include a theory-informed examination of the mechanisms of intervention effects. Projects that are responsive to this funding opportunity include R01 studies of all size, from small, single-site, three-year projects such as to adapt an intervention to the community or to test efficacy of an intervention, to large multi-site trials to test effectiveness and implementation strategies. Applications that meet any of the non-responsiveness criteria will be considered non-responsive and will not be reviewed. Implementation studies should include an evaluation of the effectiveness of the intervention in the site or sites. Years requested and project budgets should reflect the scope of the project. A description of plans for community engagement, including clear justification of the planned approach, is required. Projects that focus on populations that experience health disparities are highly encouraged.

The "CCRP Initiative: Countermeasures Against Chemical Threats (CounterACT) Therapeutics Discovery and Early-Stage Development" grant aims to fund the early-stage development of treatments to reduce the harmful health effects caused by exposure to toxic chemicals, which could be used in terrorist attacks or accidentally released from industrial sites, with the end goal of producing at least one well-characterized therapeutic candidate.

This funding opportunity is designed to support research centers in developing innovative vaccines against hepatitis C virus, targeting a wide range of applicants including universities, nonprofits, and government entities.

Through this Funding Opportunity Announcement (FOA), the National Cancer Institute (NCI) invites applications for support of investigator-initiated studies addressing mechanisms by which bariatric surgery impacts cancer risk, and seeks to draw in talented scientists who study bariatric surgery to investigate its effects on cancer, rather than shorter-term outcomes such as weight loss and diabetes.Through this Funding Opportunity Announcement (FOA), the National Cancer Institute (NCI) invites applications for support of investigator-initiated studies addressing mechanisms by which bariatric surgery impacts cancer risk, and seeks to draw in talented scientists who study bariatric surgery to investigate its effects on cancer, rather than shorter-term outcomes such as weight loss and diabetes. Background Obesity: Obesity will soon surpass smoking tobacco as the number one cause of preventable death both in the United States and worldwide. Bariatric (metabolic) surgery is the most effective strategy to achieve significant initial and sustained weight loss among individuals who are morbidly obese. Bariatric surgery provides dramatic improvement in metabolic function, associated with a reduction in type 2 diabetes mellitus (T2DM) and cardiovascular (CV) risk. Bariatric surgery also appears to reduce the risk of certain obesity-related cancers, although which cancers are favorably impacted vary by study, and the mechanism(s) driving this risk reduction is mostly speculative. Bariatric surgery is performed in over 250,000 people in the U.S. annually, and the frequency is rising. Studies evaluating which bariatric surgery procedure(s) are most effective in cancer risk reduction could help bring to light new pathways to target for cancer prevention. Bariatric Surgery: Importantly, it is not yet clear from clinical and preclinical studies if the benefit from bariatric surgery arises from weight loss alone or if there is also a surgery-specific benefit. One mechanism for a possible surgery-specific effect is elevated bile acids (BA), both intestinal and circulating, after gastric bypass surgery such as Roux-en-Y gastric bypass (RYGB) that are proposed to be central to weight loss and other metabolic benefits. The interaction between BA and intestinal microbes is also an area of intense interest. Studies have identified important changes after bariatric surgery in the composition and function of the gut microbiome, which may mediate bariatric surgery effects. Fecal microbiota transplantation (FMT) from humans or mice that had undergone bariatric surgery to germ-free recipient mice showed decreased weight gain and decreased adiposity are both transmissible traits. In addition, FMT induced important host metabolic changes including decreased energy harvest from the diet, increased resting energy expenditure, and increased lipid utilization. The data suggest a causal link between gut microbiota and the metabolic and weight loss effects of bariatric surgery. If validated, the findings will provide insight into the mechanisms driving the benefit of bariatric surgery on cancer risk and would be useful to further scientific understanding and patient care. Animal Models: Several diets or genetically induced animal models of obesity have consistently demonstrated the benefits of weight loss on cancer risk, and these obesity-induced tumor models may be adaptable to bariatric surgery studies, such as the Kras model of pancreatic cancer. Animal models have been developed to study the effects of bariatric surgery. Rodent animal models are most often used due to feasibility (low cost, ease of housing) and have been used extensively to study the mechanism(s) of bariatric surgery responsible for the reduction or elimination of T2DM and CV risk. However, very little has been reported on bariatric surgery and cancer risk despite the fact that both rat and murine models of mammary and other cancers develop in 6 months or less, making it feasible to assess mechanistic changes that influence cancer risk. Bariatric Surgery and Cancer Risk: Obese patients undergo bariatric surgery for a variety of reasons, including weight loss and improvement in metabolic dysfunction. Physician advice regarding the potential benefit of bariatric surgery and cancer risk reduction can currently only be given in generalities based on large-scale studies and not targeted to the individual. Many but not all bariatric surgery investigations document an overall cancer risk reduction among women but not men. Some but not all bariatric surgery studies have found that both women and men undergoing bariatric surgery have an increased risk of colorectal cancer (CRC). Older studies which assessed bariatric surgery and cancer risk may not be useful to guide targeted advice to patients, as one of the most common procedures performed in the past, gastric banding, is only performed in 1% of bariatric surgery procedures today. The two most common bariatric surgery procedures currently performed are sleeve gastrectomy and RYGB. As such, planned animal and/or human studies should focus on the mechanistic effects of the two procedures that are currently in common use. Human biospecimens and/or data may be available from cohorts to enhance the studies proposed including the Longitudinal Assessment of Bariatric Surgery (LABS), Adolescent Bariatrics: Assessing Health Benefits & Risks (Teen-LABS), and NCI Cohort Consortium Members. Applications that include collaborators from fields outside of cancer research will be given special programmatic consideration. Responsive applications may investigate animal models, human studies, or a combination of both. General Area of Research and Scope of Work for this FOA General Area of Research Examples of relevant areas of research include but are not limited to: Do alterations in cancer risk biomarkers occur before weight loss? If so, in what organ, tissue, or cell type do they originate? Is maximum weight loss or long-term weight loss more important for cancer risk reduction? If so, how do the two differ at a cellular and/or biochemical level? What mechanism(s) explain the evidence that bariatric surgery is more beneficial in cancer risk reduction in women than men? Does bariatric surgery increase or decrease the risk of CRC, and if so, what are the mechanism(s)? Which cancers are decreased in incidence by bariatric surgery, and what are the mechanism(s) that explain the effect? Are any cancers increased in incidence by bariatric surgery? If so, through what mechanism(s)? Does the specific bariatric surgery procedure have an impact on cancer risk? If so, what are the mechanism(s) driving the difference in impact? Does racial or ethnic background influence the impact of bariatric surgery on cancer risk, and if so, what are the mechanism(s) involved? How does bariatric surgery affect the penetrance of high-risk genetic predisposition to cancer? Scope of Work and Additional Guidance It is anticipated that studies will evaluate bariatric surgery animal models where a significant proportion of the animals develop cancer. Similarly, human studies involving individuals who will or have undergone bariatric surgery are also encouraged, so long as within the cohort to be studied the number of enrolled subjects who develop cancer is adequate to for a statistically powered endpoint linking cancer (and not a biomarker of cancer) to a molecular mechanism as the driver of cancer. When appropriate and feasible, the investigators may want to evaluate mechanisms influenced by bariatric surgery in animal models of cancer and evaluate potential changes that might correlate with humans due to bariatric surgery. We define mechanism as a biologic endpoint based on analyzed samples from bariatric surgery animal models or from subjects who have or are planned to undergo bariatric surgery. This FOA does not support studies where an epidemiologic endpoint is the primary aim of the project. The mechanism(s) to be studied should evaluate samples collected from animals or humans who have undergone bariatric surgery who did or did not develop cancer. If both animals and humans are studied, the mechanisms chosen should be based on a cancer endpoint. Applications Not Responsive to This FOA The following types of activities remain outside the scope of this FOA, and applications proposing them are non-responsive to this FOA and will not be reviewed. This FOA is not intended for epidemiologic studies, where the primary endpoint is the assessment of cancer in a cohort of animals or humans, which has undergone bariatric surgery and mechanistic studies evaluating bodily fluid or tissue samples are nonexistent or of secondary endpoints. Application that focuses entirely on in vitro investigations. Epidemiologic investigations as the primary focus of the application. Animal or human studies that do not evaluate tissue and/or bodily fluid samples collected from participants who have undergone bariatric surgery, some of which developed cancer after surgery. Application, which includes a clinical trial that does not have a bariatric surgeon as a key investigator on the team. NOTE: Applicants to this FOA are strongly encouraged to contact NCI staff as soon as possible in the development of the application (preferably no later than 12 weeks prior to the application due date) to discuss the details of their proposed clinical trial, so that NCI staff can help the applicant understand whether the proposed clinical trial is within the goals and mission of the NCI and is appropriate for this FOA.

This funding opportunity provides financial support for research projects that aim to improve the adoption and sustainability of effective health interventions, particularly in underrepresented communities, by addressing barriers and promoting equitable health outcomes.

This program provides funding to establish community-based telehealth resources that connect rural veterans with healthcare providers, improving their access to essential medical services.

This program provides funding to local governments, nonprofits, and redevelopment authorities in Pennsylvania to revitalize downtown areas and enhance community development through various improvement projects.

This funding opportunity supports clinical trials for innovative treatments and interventions targeting Alzheimer's disease, related dementias, and age-related cognitive decline, inviting applications from a wide range of eligible organizations, including universities, nonprofits, and small businesses.

This funding opportunity supports a wide range of organizations in developing and sharing innovative neuroscience technologies to enhance research and understanding of brain function.

This grant provides funding to health organizations in Cameroon to strengthen their ability to prevent, detect, and respond to public health threats and improve overall health security.

This funding opportunity supports research institutions and organizations conducting experimental studies with human participants to explore new brain stimulation techniques for treating substance use disorders.

The Kiwanis Club of Los Altos Foundation annually offers grants to organizations operating within the greater Los Altos area. Focused on supporting initiatives that align with their mission of “Serving the Children of the World,” the foundation grants financial aid to projects and programs benefiting the community, particularly youth and seniors. Eligible applicants must be 501(c)(3) organizations, with past recipients including diverse beneficiaries such as Tech Trek, Mentor Tutor Connection, and the Living Classroom. Application acceptance period is from October 1 to January 31 each year.

This funding opportunity is designed to help schools collect and utilize data to improve the health and well-being of adolescents by tracking their behaviors and experiences over time.

This grant provides funding to community organizations in Johnson County, Indiana, to develop innovative programs that address opioid use disorder through treatment, prevention, and harm reduction efforts.

Will County has allocated $225,000 in grant funding to support early child care providers within the county. This grant program aims to enhance the quality of child care services by funding improvements in educational materials, physical environments, technology, and developmental support services. The program's mission aligns with fostering a robust early childhood education ecosystem, recognizing the critical role these providers play in child development and community well-being. The grant targets DCFS Licensed Childcare Providers located in Will County. Priority is given to providers serving specific populations, including children ages birth to five in Will County R3 Zones, those receiving Child Care Assistance Program (CCAP) funds, children 0-5 years of age whose families speak English as a Second Language (ESL), children in the Early Intervention program, children with developmental or medical diagnoses, and children with active Individually Education Plans (IEP) in the public school system. The impact goal is to strengthen the capacity of these providers to offer high-quality care, particularly to vulnerable populations, ensuring equitable access to developmental and educational resources. The program prioritizes several key areas for funding. These include the acquisition of educational materials such as books, art supplies, and STEAM/STEM resources; improvements to the physical environment including safety, sanitation, furniture, and air/water filtration; technology upgrades for security systems, computer software for administrative tasks, and parent communication; and developmental supports like screening tools, consultant hiring, social-emotional program enhancements, and health screenings. The focus is on creating safe, stimulating, and technologically advanced environments that cater to the holistic developmental needs of young children. Expected outcomes include improved learning environments, enhanced safety and health standards, more efficient administrative processes, and increased access to specialized developmental support services for children. Measurable results will be seen through the implementation of new educational tools, upgraded facilities, advanced technology systems, and the provision of targeted developmental interventions. The ultimate goal is to contribute to the overall well-being and readiness for school of Will County's young children, thereby supporting the county's broader strategic priorities in early childhood development and community health.

This funding opportunity provides up to $40,000 for community groups and local agencies in the Oklahoma City Metro area to enhance public spaces through projects like tree planting and landscaping that promote public engagement and accessibility.