Grants for For profit organizations other than small businesses - Science and Technology

This funding opportunity supports researchers and organizations developing innovative prediction models for early detection of Alzheimer's Disease and related dementias, particularly focusing on data from underserved communities to address health disparities.

This program provides funding to certified community development financial institutions to strengthen their operations and expand services for small businesses and underserved communities in Pennsylvania.

This funding opportunity supports universities, research institutions, and non-profit organizations in conducting innovative research in measurement science to advance fundamental measurement methods and enhance our understanding of physics.

The Office of Naval Research (ONR) is interested in receiving a broad range of proposals for augmenting existing and/or developing innovative solutions that directly maintain, and/or cultivate a diverse, world-class Science, Technology, Engineering, and Mathematics (STEM) workforce to maintain the U.S. Navy and Marine Corps technological superiority. The goal of proposed efforts must provide solutions that establish, build, and/or maintain STEM educational pathways of U.S. citizens directly relevant to the needs of Department of Navys (DON) current and future workforce. As the capacity of the DON Science and Technology (S) workforce is interconnected with the STEM education system, DON recognizes the need to support efforts that can jointly improve STEM student outcomes and align educational and outreach efforts with Naval S current and future workforce needs. This announcement explicitly encourages programs that improve the capacity of education systems and communities to create impactful STEM educational experiences for students of all ages and the naval related workforce. Programs must aim to increase engagement in naval relevant STEM, and enhance the corresponding skills, knowledge, and abilities of participants. ONR encourages applicants to utilize current STEM educational research for informing program design and advancing STEM careers and opportunities of naval relevance.

This program provides funding to residents and community groups in the Worthington School District for projects that strengthen community ties and enhance local neighborhoods.

The FY24 RCRP RCDA supports the development of clinical or preclinical data sets and research resources that advance the field of rare cancers research and ultimately improve outcomes for individuals with rare cancers. Major gaps in patient care of rare cancers include lack of communication and dissemination strategies for rare cancers research and clinical findings within communities; lack of therapeutics and mechanistic studies to inform treatment development; lack of research and clinical resources, including patient tissues, cell, and tumor models; and lack of infrastructure for sharing data and other resources.The intent of this funding opportunity is to develop research platforms that can share resources and knowledge pertaining to available preclinical or clinical research models, molecular pathways, and therapeutic approaches to facilitate collaboration and information sharing among stakeholders such as researchers, patients, caregivers, clinicians, and other members of the rare cancers community.Clinical or preclinical datasets should strive to integrate or develop the following research resources. This list is not all-inclusive: Building and sharing rare tumor biospecimen repository with clinical annotation Databases/banks for centralizing and sharing data for patient registries that can be accessed globally Centralizing and sharing research models and molecular data related to genomics/ transcriptomics/immune profiling/proteomics/metabolomics/methylomics/bioinformatics Generating a data/reagent/model exchange program where researchers can list resources that they are willing to share and are tagged with indications that may be relevant Platform to enable or leverage longitudinal studies of disease natural history and treatment response Development of novel methods and systems for collection, sharing, and analysis of data or biospecimensApplicants should include a well-formulated project design based on a strong scientific rationale and clearly articulate how the proposed resource platform or community development addresses an unmet need in rare cancers research. Applicants should explain the advantage of their approach to developing resources or community versus standard methodologies, techniques, or scopes. A clear plan for collaboration and data sharing needs to be demonstrated. It is critical to demonstrate how the outcome of the proposed project can benefit type(s) or sub-type(s) of rare cancers. It is encouraged for the research platform/resource to have an effect on multiple types or sub-types of rare cancers.Key Elements of the Resource and Community Development Award are as follows: Impact: Outcomes of the RCDA must have potential for major impact on an unmet need in rare cancers research. A resource, as developed in the proposed research, should aim forDOD FY24 Rare Cancers Resource and Community Development Award 5long-term anticipated advantages toward greatly improving outcomes for people with rare cancers. Patient Advocate Partnership: Applications to the RCDA funding opportunity are required to include patient advocates who are involved with patient advocacy organization(s). The research team must include at least two rare cancers patient advocates who will be early and integral partners throughout the planning and implementation of the research project. Patient advocates should be involved in the development of the research question, project design, oversight, and evaluation, as well as other significant aspects of the proposed project. Interactions with other team members should be well integrated and ongoing, and not limited to attending seminars and semi-annual meetings. The patient advocates must be individuals who have been directly impacted by a rare cancer either by being diagnosed themselves or as a caretaker/family member of a patient, and they should be active in a cancer advocacy organization or within a support group focused on their rare cancer. Their role should be focused on providing objective input on the research and its potential impact for individuals with or at risk for a rare cancer. The patient advocates should have a high level of understanding of current rare cancers research. Preliminary Data: Due to the developmental nature of this award, preliminary data are not required but may be included, if available, to address the feasibility of the resource to be developed. Whether or not preliminary data are included, applications must apply solid scientific rationale and logical reasoning based on existing knowledge to the development of the proposed product. Clinical Research: Research involving human subject use is permitted under this mechanism but is restricted to studies without clinical trials. Clinical trials will not be supported. Applications focused on clinical research should demonstrate how the study will leverage clinical information to address knowledge gaps in the development of platforms that can be utilized for sharing data and tissue, the development of clinical annotation datasets, process development, and/or infrastructure development. Applied Research: Preclinical studies utilizing or creating animal models to further research into rare cancers may be supported by this funding opportunity. The RCDA is intended to support projects that will have the potential to move beyond the realm of basic research, with results that may impact clinical research or patient outcomes. Community Building: A plan describing how the rare cancers stakeholder community will be built/enhanced and the communitys involvement with developing the resource platform is required. It is also important to justify how the community is essential for the development and sustainment of the resource platform. Dissemination: A Dissemination Plan is required. The plan should describe the means by which the fully developed resource platform will be made easily available to the scientific and/or clinical community. Dissemination of resource platform will play a major role by not only educating the rare cancer community about the recent progress, but also help to develop an informational network.DOD FY24 Rare Cancers Resource and Community Development Award 6 Sustainment: A plan that outlines the sustainability of the resource in the future is required. The plan should detail the types of rare cancers that are less studied in the collaborations and the resources to be gathered, annotated, and sustained. Additional expansion and feasibility plans should be included. It is important to demonstrate how the outcomes of the current award will be continued and eventually will help the rare care cancer community, beyond the award period.A congressionally mandated Metastatic Cancer Task Force was formed with the purpose of identifying ways to help accelerate clinical and translational research aimed at extending the lives of advanced state and recurrent patients. As a member of the Metastatic Cancer Task Force, CDMRP encourages applicants to review the recommendations (https://health.mil/Reference-Center/Congressional-Testimonies/2018/05/03/Metastatic-Cancer-Research) and submit research ideas to address these recommendations provided they are within the limitations of this funding opportunity and fit within the FY24 RCRP priorities.Collaborations between researchers at military or Veteran institutions and non-military institutions are strongly encouraged. These relationships can leverage knowledge, infrastructure, and access to unique clinical populations that the partners bring to the research effort, ultimately advancing cancer research that is of significance to the Warfighter, military Families, and the American public.Innovative research involving nuclear medicine and related techniques to support early diagnosis, more effective treatment, and improved health outcomes of active-duty Service Members and their Families is encouraged. Such research could improve diagnostic and targeted treatment capabilities through noninvasive techniques and may drive the development of precision imaging and advanced targeted therapies.CDMRP encourages research on health areas and conditions that affect women uniquely, disproportionately, or differently from men, including studies analyzing sex as a biological variable. Such research should relate anticipated project findings to improvements in womens health outcomes and/or advancing knowledge for women's health.All projects should adhere to a core set of standards for rigorous study design and reporting to maximize the reproducibility and translational potential of clinical and preclinical research. The standards are described in SC Landis et al., 2012, A call for transparent reporting to optimize the predictive value of preclinical research, Nature 490:187-191 (https://www.nature.com/nature/journal/v490/n7419/full/nature11556.html). While these standards are written for preclinical studies, the basic principles of randomization, blinding, sample-size estimation, and data handling derive from well-established best practices in clinical studies.

This funding opportunity provides financial support for U.S. universities and research organizations to collaborate on developing sustainable semiconductor materials and processes using artificial intelligence, with a focus on enhancing industry practices and workforce skills.

This grant provides funding to state and local courts, as well as eligible nonprofit organizations, to obtain expert assistance for diagnosing issues, developing solutions, and implementing necessary changes within the judicial system.

The "DoD Multiple Sclerosis, Exploration - Hypothesis Development Award" is a grant that supports the exploration of innovative, high-risk concepts in MS research, with the aim of laying the groundwork for future scientific investigation, and it particularly encourages applications from new investigators in the early stages of their careers.

This program provides financial support to for-profit food businesses in northeast Washington, D.C., that aim to improve access to fresh, healthy, and affordable food in underserved neighborhoods.

Funding available through this RFA supports company formation, as well as early research and development of novel oncology therapeutics, devices, treatment-oriented information technology products, diagnostics, or tools. The objective of the SEED Award program is to start with an interesting technology and to progress it toward a commercially viable business opportunity, i.e., make it more attractive to private funding agents. Typically, applicants have completed the following activities: Identified a novel therapeutic, diagnostic technology, or clinical tool and shown a biological effect Conducted preliminary safety and toxicology testing (in the case of therapeutic agents) Shown the product can be manufactured at small scale or as a prototype Assessed the business opportunity and organized a business plan that begins to address key issues (clinical utility, target market, financial plan, IP strategy, technical challenges, etc.) and lays out a preliminary development plan (formulation, toxicology, scale up, IND-enabling studies, phase 1 clinical trials, regulatory pathway, etc.). Established a company

This grant provides financial support to small businesses and non-profits in Lebanon County, Pennsylvania, to enhance their operations through professional development, paid internships, business improvements, and technology upgrades.

This grant provides funding for U.S.-based researchers to explore innovative tissue engineering and mechanobiology solutions using the unique microgravity environment of the International Space Station, with the goal of improving health outcomes on Earth.

This grant provides funding for researchers to develop and advance treatments for Duchenne Muscular Dystrophy, benefiting patients of all ages, including military personnel and their families.

The FY24 ARP Discovery Award supports innovative, non-incremental, high-risk/potentially high-reward research that will provide new insights, paradigms, technologies, or applications in autism research. Studies supported by this award are expected to lay the groundwork for future avenues of scientific investigation regarding an important question for autism research and/or the ASD community. The proposed research project should include a well-formulated, testable hypothesis based on a sound scientific rationale and logical reasoning. Preliminary data are not required but is allowed. The outcome of research supported by this award should be the generation of robust preliminary data that can be used as a foundation for future research projects and applications for funding.The FY24 ARP Discovery Award seeks applications from all areas of research that will help fulfill the programs vision to improve the lives of individuals with ASD now and in their future, as well its mission is to promote innovative research that advances the understanding of ASD and leads to improved outcomes.

This grant provides funding to Illinois nonprofit organizations to create legal information centers and projects that help residents understand and navigate the legal system, particularly in areas like family law, housing, and immigration.

The DoD Traumatic Brain Injury and Psychological Health, Focused Program Award is a funding opportunity aimed at accelerating the development of solutions to critical questions related to traumatic brain injury and psychological health, through multidisciplinary research programs that can significantly impact these conditions through clinical applications, with a budget of approximately $46.5M to fund around six projects.

The MassDEP Reduce, Reuse, Repair Micro-Grant program offers grants of up to $10,000 to various entities, including for-profit and non-profit organizations, regional authorities, municipalities, and schools/colleges in Massachusetts. The program's core mission is to support short-term waste reduction projects across all counties within the state. This initiative directly aligns with a broader strategic goal of environmental protection by fostering sustainable practices and extending the lifespan of products, thereby diverting waste from landfills. The program's focus on reduction, reuse, and repair is a fundamental aspect of circular economy principles, which are critical to the foundation's theory of change in promoting a more sustainable Massachusetts. The program targets a diverse group of beneficiaries, including businesses, non-profits, governmental bodies, and educational institutions within Massachusetts. The primary impact goal is to significantly reduce waste generation and prolong product utility through donation, rescue, reuse, and repair activities. This aims to create a ripple effect, encouraging communities and organizations to adopt more environmentally responsible behaviors. By providing financial support for specific projects, MassDEP seeks to empower these entities to implement innovative solutions that contribute to a cleaner, more sustainable environment. The program prioritizes projects that directly contribute to waste reduction and product longevity. This includes initiatives such as purchasing inventory technology for operational efficiencies, developing programs for collecting and redistributing reusable items (clothing, electronics, home goods), implementing reusable transport packaging systems, converting to reusable food service ware, installing bulk dispensing systems, and establishing or expanding repair programs for furniture, appliances, electronics, and textiles. Additionally, the program supports the creation of food donation and distribution programs, community repair training, deconstruction initiatives, and the promotion of tool-lending libraries and community repair events. These diverse focuses ensure a comprehensive approach to waste reduction across various sectors and community needs. Expected outcomes include a measurable decrease in waste sent to landfills and an increase in the lifespan of various products through their reuse and repair. Projects are anticipated to result in enhanced operational efficiencies for participating organizations, greater accessibility to reusable goods for communities, and the establishment of new, or expansion of existing, waste reduction infrastructure. The program also aims to foster a culture of sustainability through education and community engagement, leading to long-term behavioral changes. Measurable results could include metrics on tons of waste diverted, number of items repaired or reused, and the reach of educational and training programs. Ultimately, these efforts contribute to MassDEP's strategic priority of promoting environmental stewardship and resource conservation across Massachusetts.

This funding opportunity provides financial support for nonprofits, public-private partnerships, and industry consortia in North Dakota to develop and implement innovative autonomous agriculture projects that enhance technology, infrastructure, and workforce systems in the state.

Funding available through this RFA supports the ongoing research and development of innovative products, services, and infrastructure with significant potential impact on patient care. Generally, at this stage, the company has identified and characterized a lead compound; demonstrated efficacy in multiple translationally relevant animal models; completed pilot/dose ranging toxicology studies; determined the feasibility of a scalable, GMP compliant manufacturing process, including release assays; and identified a prototype formulation suitable for further development. The applicant is typically within one year from filing an IND/IDE or already in Phase 1. With appropriate justification, companies may use CPRIT funds to support the following: Studies that establish preclinical proof of concept (safety and efficacy) CMC/manufacturing development GLP safety studies to support INDs Phase 1 in humans to establish safety and a recommended dose for phase 2 Phase 2 studies to determine safety and efficacy in initial targeted patient population