Grants for Public and State controlled institutions of higher education - Federal

This funding opportunity supports innovative research projects that develop new technologies for cancer analysis, targeting a wide range of applicants including universities, nonprofits, and small businesses.

This grant provides funding to Tribal Child Care and Development Fund agencies and their research partners to improve data systems and research capacity for early childhood programs in tribal communities.

The Public Diplomacy Section of the U.S. Embassy in Bangkok announces an open competition for a cooperative agreement under the Young Southeast Asian Leaders Initiative (YSEALI) to develop and implement the YSEALI AI FutureMakers Regional Workshop a six-day workshop in Thailand (inclusive of arrival and departure days) on exploring the transformative power of Artificial Intelligence (AI) in driving social innovation. Please note that this award is subject to availability of funding. Please carefully follow all instructions below. Priority Region: Brunei, Cambodia, Indonesia, Malaysia, Myanmar, Philippines, Laos, Singapore, Thailand, Vietnam, and Timor-Leste. Program Objectives: YSEALI (yseali.state.gov) is the U.S. governments signature initiative to engage emerging leaders in Southeast Asia. The program aims to create a network of young Southeast Asian leaders who work across national borders to address common problems. Through a variety of programs and engagements, YSEALI seeks to build the leadership capabilities of youth in the region, strengthen ties between the United States and Southeast Asia, and develop a community of leaders addressing regional concerns. YSEALI is open to young leaders ages 18-35 who are both citizens and residents of the Association of Southeast Asian Nations (ASEAN) member countries (Brunei, Burma, Cambodia, Indonesia, Laos, Malaysia, the Philippines, Singapore, Thailand, and Vietnam) or Timor-Leste. YSEALI programs focus on four themes (Economic Growth, Sustainable Development, Education, and Civic Engagement) because youth in the region identified them as priorities. YSEALI also organizes annual Regional Workshops across Southeast Asia on strategic topics. Artificial Intelligence (AI) is a transformative technology with profound implications for society, government, the economy, and the environment worldwide. Within ASEAN, governmental, societal, and economic actors are actively engaged in discussing the applications of this technology and the role of regulation, for example in the ASEAN Guide on AI Governance and Ethics approved at the 4th ASEAN Digital Ministers Meeting (ADGMIN) on February 2, 2024. Development of AI within Southeast Asia is complicated by the wide variation in economic development and technological capacity between member states, and 2025 is an opportune time to engage the YSEALI community in efforts to leverage AI to foster shared, sustainable, and inclusive growth throughout the Indo-Pacific Region. The YSEALI AI FutureMakers Regional Workshop will convene young people from throughout Southeast Asia to leverage the power of science, technology, and active civil society participation to address critical challenges and expand opportunities in Southeast Asia. The workshop will emphasize the importance of strengthening people-to-people connections, ensuring that technological advancements benefit not just economies, but societies at large, reinforcing the bridge between innovation and human-centric development. Through this workshop, the participants will not only address immediate challenges but will also lay the groundwork for long-term partnerships and collaborations that will drive positive change and development across the region. This workshop will bring together 60 YSEALI members from ASEAN countries and Timor Leste with a keen interest in leveraging technology to address regional and global challenges. It will offer a unique opportunity for YSEALI leaders to delve deeply into the transformative potential of Artificial Intelligence (AI), with a focus on at least one of the YSEALIs core themes: economic empowerment, civic engagement, education, and environmental sustainability. Participants will engage in comprehensive discussions and hands-on activities aimed at harnessing AI for sustainable change. Within the realm of economic empowerment, the proposal should explore how AI technologies can catalyze socio-economic growth by creating new opportunities for entrepreneurship, enhancing livelihoods, and fostering inclusive economic development. Through case studies and interactive sessions, participants should gain insights into innovative AI-driven business models and strategies that promote equitable access to resources and opportunities. For civic engagement, the proposal should explore how AI can be used to bridge societal gaps and empower marginalized communities. Participants will consider successful AI projects that increase citizen access to information and political participation, while examining the risks of AI perpetuating inequalities that exist within training data and other source material and strategies to mitigate these risks. In the field of education, the proposal should create space for participants to explore how AI can improve access and quality of education, including language learning among Southeast Asias diverse populations; enhanced virtual resources; and/or teacher training in remote or rural communities, along with the ethical challenges of AI generated content and promoting critical thinking skills to detect and resist misinformation. In the context of environmental conservation, the proposal should highlight the potential of AI for monitoring and managing natural resources, protecting wildlife, and mitigating the impacts of climate change. Through interactive discussions and fieldwork at AI-driven organizations specializing in environmental conservation, participants should explore cutting-edge technologies and data-driven approaches that support sustainable environmental stewardship and biodiversity preservation. Through a combination of theoretical insights, practical case studies, hands-on activities, and collaborative discussions, the YSEALI AI FutureMakers Regional Workshop should equip participants with the knowledge, skills, and tools they need to harness the transformative potential of AI for building sustainable, inclusive, and equitable communities throughout Southeast Asia. The proposal should include workshop follow-on activities such as virtual collaborative work, projects funded through small seed grants, and/or ongoing mentorship. The follow-on activity should be included in the monitoring and evaluation plan. The proposal should include a pre and post workshop survey to measure the overall effectiveness of the workshop as well as any changes to the participants knowledge of the workshop topic. Workshop speakers/facilitators/mentors should be citizens of the United States, an ASEAN member country, or Timor-Leste. The workshop should also include a cultural or community service component that promotes ASEAN unity, and the United States as a partner to ASEAN. The recipient is expected to develop syllabus materials and an event program with participant and speaker biographies, as well as design banners, backdrops, and other printed materials. The recipient is expected to design a digital engagement strategy for workshop participants and social media audiences, including live video or live online engagement during the program. No new website specific to the event should be created or launched. Domain hosting and build costs will not be covered. Participants and Audiences: The recipient will coordinate with U.S. Embassy Bangkok and with the U.S. embassies in ASEAN and Timor-Leste to recruit and select the final 60 participants. Participants will be between the ages of 18-35 and a keen interest in leveraging AI technology to address and solve one of the following issues: economic empowerment, civic engagement, education, and environmental sustainability, as well as collaborating with others from diverse backgrounds and building networks for future initiatives. The recruitment process should ensure that the pool of applicants reflect different regions of the country, not just capital cities. All participants must be proficient in written and spoken English. All programs must include participants from all ten ASEAN member countries and Timor-Leste. The workshop will be conducted in English. The recipient will be responsible for arranging and using cooperative agreement funds to cover all elements related to participant and staff travel including international and domestic flights, visas, travel to and from airports, visas, accommodations, per diem, meals during the program, insurance, COVID-19 testing, etc. B. FEDERAL AWARD INFORMATION Length of performance period: September 2024 to December 2025 Number of awards anticipated: One Award amounts: Award may range from a minimum of $150,000 to a maximum of $250,000. Total available funding: $250,000 Type of Funding: FY24 Public Diplomacy Funds Anticipated program start date: September 2024 This notice is subject to availability of funding. Funding Instrument Type: Cooperative agreement The U.S. Embassy Bangkok will have substantial involvement in the development, content, and schedule of the workshop. In consultation with U.S. Embassy Bangkok, the award recipient must actively engage all relevant U.S. embassies related to the recruitment and selection process as well as communication with the participants. Working closely with U.S. Embassy Bangkok, the recipient of this cooperative agreement shall develop a robust program for the workshop; schedule the event at a mutually agreed upon location; manage the application and selection process through a secure portal; develop the agenda and content for the workshop; recruit speaker(s); manage all travel logistics for participants and speakers; and generate content for social media and other publicity. The recipient is expected to provide all design files, photos and video recorded, as well as a promotion-ready, U.S. Embassy-approved photo album and a video series of the workshop after completion. Regular, transparent communication via email, phone and video conference calls and face-to-face meetings (as appropriate) with the Grants Officer, Grants Officer Representative, and Program Officer throughout the period of performance is critical to the success of this cooperative agreement. All major elements of the program and its content require advance approval by U.S. Embassy Bangkok, including, but not limited to: Choices of dates, venue, accommodations, and menus; Final selection of participants, mentors, and speakers (from the United States, an ASEAN member country, or Timor-Leste); Titles, format, and content of workshop sessions and other program activities; Design and content of all marketing materials, publicity, and media products. Program Performance Period: Proposed programs should be completed in 12 months or less. The workshop must be a minimum of six full days, including travel days. C. ELIGIBILITY INFORMATION 1. Eligible Applicants The following organizations are eligible to apply: U.S. public and private educational institutions U.S. not-for-profit organizations, including think tanks Foreign public and private educational institutions Foreign not-for-profit organizations, including think tanks 2. Cost Sharing or Matching Cost sharing is not required. 3. Other Eligibility Requirements In order to be eligible to receive an award, all organizations must have a unique entity identifier (Data Universal Numbering System/DUNS number from Dun Bradstreet), as well as a valid registration on www.SAM.gov. Please see Section D.3 for information on how to obtain these registrations. Individuals are not required to have a unique entity identifier or be registered in SAM.gov. Please refer to ‘related documents’ tab for full application details. If you have any questions about the grant application process, please contact: [email protected].

PDS Sofia invites proposals for programs that bolster the people-to-people ties between the United States and Bulgaria through cultural and exchange programming that highlights shared values and promotes bilateral cooperation. All programs must include an American cultural element, or connection with American expert/s, organization/s, or institution/s in a specific field that will promote increased understanding of U.S. policy and perspectives and promote shared values. Competitive proposals should focus on one or more of the following priority themes: Promote leadership skills, civic engagement, entrepreneurship, and innovation among secondary and university students. Deepen the social, cultural, and educational connections between the United States and Bulgaria, especially through the development of active, sustainable alumni networks. Boost public understanding of and support for Bulgarias role as a strong NATO Ally as it celebrates its 20th year in the Alliance. Develop youth skills in Science, Technology, Engineering, the Arts, and Mathematics (STEAM), especially focused on assisting youth from underserved, vulnerable, or rural communities (outside major metropolitan areas). Strengthen the development of robust independent media and civil society organizations to bolster civic participation and improve societal trust in democratic institutions. Increase media and digital literacy and improve Bulgarian societys resilience to disinformation. Advance the inclusion and integration of historically underserved and vulnerable communities, including women, Roma and other minority groups, LGBTQI+ individuals, Ukrainian refugees, other migrants, and disadvantaged youth. Increase interconnectivity between Bulgaria and other countries in the region, including joint projects that foster cooperation between the citizens of Bulgaria and North Macedonia. Promote dialogue and civic participation in programs that confront climate change and that advance environmental sustainability and energy diversification.

A. PROGRAM DESCRIPTION The Public Diplomacy (PD) section of the U.S. Embassy Zimbabwe under the U.S. Department of State announces an open competition for a Rural Reading Program. The PD section invites proposals from organizations to implement a secondary school reading program for girls in rural schools from the Matabeleland North Province. The program will improve English skills, literacy, communication capability, and critical thinking. In partnership with the U.S. Embassy, the grantee will identify five (5) rural schools in Matabeleland North, selecting 30 students and two English teachers per school for participation in the program. The program will use books by U.S. authors that focus on leadership, equality, and womens empowerment and will employ U.S.-style pedagogy practices, including an emphasis on open discussion and constructive debate. The grantee will design and implement the program, facilitate access to rural schools, and distribute books. The grantee will ensure that participants are resourced to engage fully in program activities. This may include, for example, the provision of solar lamps as needed. Suggested activities for the program include film screenings, writing workshops, essay competitions, and a graduation ceremony at the conclusion of the program. The successful grantee should have experience working in rural education development and demonstrate ability to responsibly manage funds, coordinate logistics, and produce high quality programs and financial reports. Priority Region: Project activities must take place in Matabeleland North in Zimbabwe. Program Objective: To improve rural students literacy and critical thinking skills in support of their roles as leaders in their schools and communities. Participants and Audiences: Girls between the ages of 14 to 19 years, enrolled in under-resourced secondary schools in Matabeleland North. B. FEDERAL AWARD INFORMATION Length of performance period: 12 Months from date of award Number of awards anticipated: One (1) Award amounts: US$24,000 Total available funding: US$24,000 Type of Funding: 2024 Public Diplomacy Funds Smith-Mundt Anticipated program start date: January 2025 Funding Instrument Type: Grant THIS NOTICE IS SUBJECT TO AVAILABILITY OF FUNDING. D. APPLICATION AND SUBMISSION INFORMATION To Request Application Package: Email [email protected]; an automatic reply with the application forms will be sent. Forms are also available at www.grants.gov Content and Form of Application Submission: Content of Application the proposal should: Clearly serve the goals and objectives of this funding opportunity; Be specific and concise in describing the who, what, why, when, where, how and cost aspects of the project; Provide all documents in English; and Include a budget narrative and a budget table in U.S. dollars breaking down costs per unit rates, quantities as well as totals. Application Forms required: (in the Application Package) Completed application (form attached) Detailed projected budget (form attached) SF-424 (Application for Federal Assistance Organizations) or SF-424-I (Application for Federal Assistance Individuals) SF-424A (Budget Information for Non-Construction programs) SF-424B (Assurances for Non-Construction programs) Attachments Letters of support from program partners describing the roles and responsibilities of each partner If your organization has a Negotiated Indirect Cost Rate Agreement (NICRA) and includes NICRA charges in the budget, your latest NICRA should be included as a PDF file. If you do not have a NICRA, indirect and overhead costs cant be over 10% of the budget. Official permission letters, if required for program activities. 2. Required Registrations: All organizations (not individuals) whether based in the United States or in another country, must have a Unique Entity Identifier (UEI) and an active registration with the SAM.gov. Steps to acquire UEI and registration: https://login.gov create an account. To access SAM.gov an organization is required to have a Login.gov account. https://www.SAM.gov registration which will generate a unique entity identifier (UEI) The UEI are assigned when an organization registers or renews its registration in SAM.gov Organizations should renew their registration once a year to maintain an active registration status in SAM.gov. It is the responsibility of the applicant to ensure it has an active SAM registration. Note: The process of obtaining or renewing a SAM.gov registration may take anywhere from 4-8 weeks. Please begin your registration as early as possible. Organizations based outside of the United States and that do not pay employees within the United States do not need an EIN from the IRS but do need a UEI number prior to registering in SAM.gov. Organizations based in the United States or that pay employees within the United States will need an Employer Identification Number (EIN) from the Internal Revenue Service (IRS), and a UEI number prior to registering in SAM.gov. If an organization plans to issue a sub-contract or sub-award, those sub-awardees must also have a unique entity identifier (UEI number). Please note the UEI for sub-grantees is not required at the time of application but will be required before an award is processed. If an organization does not have an active registration in SAM.gov prior to submitting an application, the application will be deemed ineligible. Note: As of April 2022, a DUNS number is no longer required. 3. Submission Dates and Times PD Harare will accept proposals starting May 25, 2024. All applicants should submit their proposals prior to July 31, 2024 for consideration. 4. Other Submission Requirements All application materials may be emailed to [email protected] (with RURAL READING PROGRAM GRANT PROPOSAL in the subject line).

The Catalyze Product Definition Funding Opportunity Announcement (FOA) offers early-stage financial support for the development and testing of medical device prototypes, identification of disease targets for diagnostics, and creation of research tools to treat heart, lung, blood, and sleep (HLBS) disorders, with the goal of advancing these projects to a stage where they can qualify for the NHLBI Catalyze Preclinical program or secure further development funding from other sources.

This funding opportunity provides financial support to nonprofit organizations, tribal governments, and legal service providers to enhance legal assistance for victims of domestic violence, sexual assault, dating violence, and stalking.

The Plant Genome Research Program (PGRP) supports genome-scale research that addresses challenging questions of biological, societal and economic importance. PGRP encourages the development of innovative tools, technologies and resources that empower a broad plant research community to answer scientific questions on a genome-wide scale. Emphasis is placed on the scale and depth of the question being addressed and the creativity of the approach. Data produced by plant genomics should be usable, accessible, integrated across scales and of high impact across biology. Training, broadening participation, and career development are essential to scientific progress and should be integrated in all PGRP-funded projects. Two funding tracks are currently available: RESEARCH-PGR TRACK: Genome-scale plant research to address fundamental questions in biology, including processes of economic and/or societal importance. TRTech-PGR TRACK: Tools, resources and technology breakthroughs that further enable functional plant genomics.

This grant provides funding to a U.S. organization to support foreign students from key regions in gaining technical and professional skills through community colleges, enhancing global engagement and economic stability in their home countries.

With this solicitation, OJJDP seeks to fund a training and technical assistance (TTA) provider to build capability and capacity of diversion programs serving justice-involved youth populations with substance use disorder and co-occurring mental health and substance use disorder needs. The successful applicant will lead a national TTA program and administer a subaward program providing subawards to local demonstration sites to improve responses and outcomes for youth with substance use disorders and co-occurring mental health and substance use disorders who come into contact with the juvenile justice system, or who are at high risk of contact, by diverting these youth toward community-based treatment to address their unique mental and behavioral health needs to prevent them from entering the formal justice system.

This funding opportunity supports short courses that train researchers in advanced mental health research skills, targeting graduate students, postdoctoral scholars, and early-career investigators across the nation.

The DoD Reconstructive Transplant, Advanced Technology Development Award is a funding opportunity aimed at supporting research that translates promising preclinical findings into products or knowledge-based resources that can improve reconstructive transplantation, particularly for military service members, veterans, and their families, with a budget not exceeding $1.0M for single PI applications and $1.5M for multiple PI applications.

This funding opportunity provides financial support for collaborative forest and ecosystem restoration projects in the western U.S. and Pacific Islands, targeting state and local agencies, Tribes, nonprofits, and universities to improve environmental health and resilience.

This Funding Opportunity Announcement (FOA) invites applications specific to sample acquisition, genome wide association studies, whole genome sequencing, quality control checking, variant calling, data calling, data sharing, data harmonization, and analysis that will support the generation of data from multi-ethnic cohorts for the Alzheimer's Disease Sequencing Project Follow-Up Study 2.0: The Diverse Population Initiative.Funding Opportunity Description Background This Funding Opportunity Announcement (FOA) is issued in response to National Alzheimer's Project Act (NAPA) milestones for the genetics of Alzheimer's disease (AD) and AD-related dementias (ADRD) in order to support the ongoing Alzheimer's Disease Sequencing Project (ADSP). The overarching goals of the ADSP are to: 1) identify new genes involved in AD/ADRD; 2) identify gene alleles contributing to increased risk for, or protection against, the disease; 3) provide insight as to why individuals with known risk factor genes escape from developing AD/ADRD; 4) identify potential avenues for therapeutic approaches and prevention of the disease; and 5) fully reveal the genetic architecture of AD/ADRD in multiple race and ethnicity categories. The samples for the ADSP were selected from well-characterized, diverse study cohorts of individuals both with and without an AD diagnosis as well as with and without known risk-factor genes. This study of human genetic variation and its relationship to health and disease involves a large number of study participants and aims to capture not only common single nucleotide variations, but also rare copy number and other structural variants that are increasingly thought to play an important role in complex diseases. This FOA uses the Office of Management and Budget (OMB) official categories of race and ethnicity. For the purposes of this FOA, ethnic categories (i.e., Hispanic/Latino) and racial categories (i.e., American Indian/Alaska Native; Asian; and Black/African American) will be referred to as diverse populations . Cohorts of participants from individual ethnic or race categories will be referred to as diversity cohorts . Individuals in diversity cohorts will be referred to as diversity participants . The ADSP has identified a large number of variations in the genomes of individuals affected with AD. The study population for these analyses was predominantly White. Lack of diversity in the sample set limits the possible clinical utility of emerging tools and methodological approaches for identifying potential therapeutics for a large proportion of the population. This, in turn, underscores the urgency to ensure appropriate representation of diverse populations to prevent potential gaps in the translation of research efforts to these populations. To this end, the initial ADSP findings will be pursued in diverse populations in the next phase of the study, called the ADSP Follow-Up Study (FUS) 2.0: The Diverse Population Initiative and referred to here as ADSP FUS 2.0. The long-term goals of the ADSP FUS 2.0 are to: 1) move the field closer to enabling prediction of who will develop AD; 2) fully characterize AD subtypes by studying endophenotypes in diverse populations; 3) better understand the differences in the genetic underpinnings of AD pathogenesis among diverse populations; and 4) identify specific therapeutic targets based upon diverse population. Important instances of unique AD/ADRD genetic variation have already been identified in epidemiological cohorts with Hispanic/Latino and Black/African American participants. Variants for AD are rare and can only be identified with a larger number of study participants. Variants occur at different frequencies in different populations, and certain risk variants may be much easier to detect in some populations. US diversity groups are not represented in ADSP data in sufficient numbers to enable meaningful study, so the genetics of these populations remain largely unstudied. Hispanics/Latinos, Blacks/African Americans, and Asians are the largest and fastest-growing minority groups in the US, and AD/ADRD imposes a high economic and social burden upon the US population. US Asian population ADSP genetic data are completely absent. Numbers of Hispanic/Latino and Black/African American participants in the US remain insufficient to provide statistical significance for identification of rare or very rare variants. Variants in the Alzheimer’s genome are largely rare or very rare in the population. It is estimated that for 80% certainty for single variant testing for rare variants, ~16,100 cases and ~16,100 controls are needed for a variant with a minor allele frequency of 0.5% in the population; single variant testing for rare variants indicate that for 90% certainty, ~18,500 cases and ~18,500 controls are needed for each population for a variant with a minor allele frequency of 1% in the population. To ensure that there are sufficient numbers of study participants to achieve statistical power for analysis of rare or vary rare variants in the three largest diversity cohorts AD/ADRD genome given the available funding, the primary focus of the ADSP FUS 2.0 will be on Hispanic/Latino, Black/African American, and Asian populations. Consortia should take advantage of cohorts already recruited or in planning for recruitment to obtain sufficient numbers; sharing diversity data across consortia is essential to the success of this effort. Investigators with cohorts representing other racial/ethnic categories, such as American Indians/Alaskan Natives, are encouraged to apply for funding separately under other NIA-supported FOAs. Sequencing of participants from founder populations such as those from Africa and Asia is allowed under this FOA in order to understand population substructure and ancestry-informative markers. A small amount of sequencing of Whites to bring significance to the 90% certainty of significance level will be allowed for rare or very rare variants for the US population; however, it is expected that the vast majority of sequencing in the ADSP FUS 2.0 will be done in Hispanics/Latinos, Blacks/African Americans, and Asians. Accelerated identification of AD/ADRD genes, gene clusters, and endophenotypes driven by genetic and ethnic/racial characteristics will move the field toward selection of participants with similar endophenotypes to improve outcomes of clinical trials. The community is now able to layer different types of data to identify these endophenotypes. Analytic approaches are being developed for analysis of structural and rare variants, endophenotypes, and cross-phenotype genetic analyses to modify and/or apply analytic methods to data that are increasingly complex. In order to identify optimal drug targets, the full landscape of genetic variants must be identified and characterized. Much work remains to develop analytic methods and resources to understand the functional significance of variants, particularly noncoding variants, in diverse populations. Under this funding opportunity announcement, studies that perform analysis of sequence data may include analysis of the functional genomic studies of regions of interest. Diversity datasets will need to be integrated and harmonized to fully annotate the AD genome. This may mean assembling annotation data such as that provided by ENCODE and similar approaches to help understand whether clusters of genes in the same network or with common function may be a component of the disease etiology that varies by ethnic and racial category. Applicants are encouraged to devise analysis plans to include data from genome wide association studies (GWAS) for AD; imputation analysis; ADSP whole exome and exome chip data, and whole genome AD sequencing efforts; related genetic data such as in deep (long read) sequencing analyses generated on AD subjects; and functional genomics data. Research Objectives NIA intends to support studies most likely to meet a major goal of this FOA: to identify and confirm a full set of rare variants contributing to AD/ADRD endophenotypes in diversity cohorts to enhance the probability of identifying potential therapeutic approaches for risk and prevention. Both sequencing and data analysis will be supported under this FOA. Applicants to this FOA for the ADSP FUS 2.0 should propose to: 1) sequence particular diverse study cohorts; 2) analyze either the entire dataset (cases and controls) or components of the dataset; or 3) both sequence and analyze these data. Justification for the choice of the approach must be provided. Applicants proposing to analyze only a component of the total cohort (i.e., selected cohorts or diverse subpopulations) should propose power calculations that support the likelihood of gene discovery. Applicants should design plans that clearly define which ADSP FUS 2.0 datasets, diverse subpopulations, and/or endophenotypes will be analyzed. Along with analysis of data funded under the present FOA, analysis plans for the ADSP FUS 2.0 should include data from diversity cohorts in the ADSP FUS funded under PAR-17-214, PAR-18-890, and PAR-19-234 where possible. The design and use of large-scale storage capacity with appropriate security and backup measures to support analytical capabilities should be considered. Successful applications are anticipated to involve research conducted by multidisciplinary teams of investigators and should describe a comprehensive plan to develop leading-edge, innovative approaches for the analysis of whole genome sequence (WGS) and related genetic data. Analysis should encompass the criteria set out by the ADSP FUS funded under PAR-17-214, "Analysis of Data from NIA's Alzheimer's Disease Sequencing Project Follow-Up Study (U01)." In particular, these criteria include ethnic/racial diversity; autopsy-confirmed cases/controls, especially for non-European ancestry; availability of longitudinal data; no age limit for cases; cases unrelated to each other; and availability of comparable controls. It is expected that the scientific environment in which the work will be done will contribute to the probability of success of the project and of the ADSP as a whole. Institutional support, equipment and other physical resources available to the investigators should be adequate for the project proposed, leveraging existing NIA-funded resources. Both the project itself and the ADSP should benefit from unique features of the scientific environment, subject populations, or collaborative arrangements. For applicants performing data analysis, it is expected that they will have the capacity to analyze whole-genome sequence data from sufficient numbers of affected and unaffected individuals to achieve statistical significance for rare or very rare variants in diverse groups. The successful milestone-driven ADSP FUS 2.0 application would consist of a group of researchers with expertise in the genetics of complex neurological diseases, including AD, and the field of whole genome sequencing, as well as statisticians and other experts who will participate in study design and analysis. Successful applicant(s) may be expected to collaborate not only within their own study, but also with other PD(s)/PI(s) funded under this and related FOAs. Engagement of existing NIA-supported infrastructure is considered essential to the success of the project, so applicants should plan to financially support the National Central Cell Repository for Alzheimer’s Disease (NCRAD); The American Genome Center (TAGC) at the Uniformed Services University for the Health Sciences (USUHS) or another NIA-approved, large-scale sequencing center; the Genome Center for Alzheimer's Disease (GCAD); and the NIA Genetics of Alzheimer’s Disease Data Storage Site (NIAGADS) for their efforts in the ADSP. Applicants should develop key quantitative milestones with a timeline for accomplishment. Quality control (QC) and data harmonization will be performed by GCAD. The order and process for data transfer, quality control checking, and data harmonization will be agreed upon by the ADSP as a whole and will follow closely the existing paradigm. Under the present FOA, the ADSP will improve the likelihood of analyzing sequence data on enough different examples of events that change the genetic architecture of AD such that these data, when analyzed with existing ADSP datasets, will enhance the ability to better understand the genetic underpinnings of AD and to obtain a better understanding of rare risk and protective variants. The availability of high-quality, extensive phenotypic information on study participants is a critical consideration. Study design should include analysis of data from study participants with quantitative trait measures to more clearly define endophenotypes. Similarly, participants whose data will be used as controls should be well characterized. Applications considered for funding must effectively leverage NIA and NIH investments in infrastructure to support studies related to the genetics of Alzheimer’s disease. The investigators funded under this FOA may utilize information from existing NIA- and NIH-funded research resources or other federal websites such as: The NIA Genetics of Alzheimer’s Disease Data Storage Site (NIAGADS) The Genome Center for Alzheimer's Disease (GCAD) The National Central Cell Repository for Alzheimer’s Disease (NCRAD) The National Alzheimer's Coordinating Center (NACC) The Alzheimer's Disease Genetics Consortium (ADGC) The Alzheimer's Disease Research Centers (ADRCs) Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) The Collaborative for Alzheimer’s Disease Research (CADRE) The Alzheimer's Disease Neuroimaging Initiative (ADNI) Alzheimer's Disease Related Dementias (ADRD) The National Alzheimer’s Project Act (NAPA) Other websites designed to store and distribute data related to AD

This program provides funding to support scientists and engineers returning to academic research after a break, helping them reengage with innovative projects or acquire new skills to advance their careers.

This funding opportunity is designed to support innovative research and development projects that enhance military logistics, supply chain resilience, and operational readiness for the Department of Defense.

This grant provides funding to organizations that will educate and promote financial support for living organ donors, particularly in underserved communities, to increase awareness and access to organ donation services.

This NOFO seeks proposals from eligible applicants for activities to establish and operate a CHIPS Manufacturing USA Institute focused on digital twins with integrated physical assets and computational capabilities (digital assets) to tackle important semiconductor-industry manufacturing challenges. The CHIPS Manufacturing USA Institute will join an existing network of seventeen Institutes designed to increase U.S. manufacturing competitiveness and promote a robust R infrastructure. The Institute will manage a portfolio of Institute-led projects and competitively funded Member-led projects, including Education and Workforce Development (EWD) activities, basic and applied research, and technology demonstrations.

It is well documented that many investments in Africa, including in Liberia, fail to meet internationally accepted standards. This trend continues in part because of host countries lack of awareness, capacity, and governance. This project aims to address these weaknesses by bringing together government, civil society, journalists, academics, and other key stakeholders to build Liberias internal capacity to ensure further investments and projects have improved standards and mechanisms in place to monitor and penalize non-compliance. The project will include components that offer stakeholders: investment best global practices; case studies involving how to advance transparency in negotiating large investment deals in Africa; training/advising government officials on developing legal and regulatory investment frameworks; mentoring on public awareness campaigns around investment standards; and seminars in investigating investment-related challenges and successes in the African context. Projects should target: Countering lending and investment projects that fail to adhere to internationally accepted investment practices and as a result put at risk Liberias sovereignty, socio-economic well-being, and biodiversity.

This grant provides funding to U.S. universities to support early-career faculty members in developing innovative research related to space technology, specifically in advanced diagnostics for spacecraft atmospheric entry and autonomous spacecraft navigation using machine learning.