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Grants for Small businesses - Federal

Explore 1,527 grant opportunities

BRAIN Initiative: Reagent Resources for Brain Cell Type-Specific Access to Broaden Distribution of Enabling Technologies for Neuroscience (U24 Clinical Trial Not Allowed)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jun 15, 2027

Date Added

Sep 26, 2024

This funding opportunity provides financial support to U.S. institutions, particularly those historically underfunded, to produce and distribute specialized tools for neuroscience research focused on specific brain cell types.

Education
State governments
NIAID Physician-Scientist Pathway to Independence Award (K99/R00 Clinical Trial Required)
$698,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Feb 12, 2026

Date Added

Jan 9, 2023

This funding opportunity supports postdoctoral researchers with clinical doctorate degrees in transitioning to independent faculty positions while leading their own clinical trials in biomedical research.

Health
State governments
Engineering of Biomedical Systems
$10,400,000
National Science Foundation
Federal
Rolling

Application Deadline

Not specified

Date Added

Jan 3, 2025

This program provides funding for researchers to develop innovative engineering solutions that improve our understanding of biological systems and enhance medical diagnosis, treatment, and healthcare delivery.

Science and Technology
For profit organizations other than small businesses
NIH Science Education Partnership Award (SEPA)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jul 7, 2026

Date Added

May 29, 2025

This funding opportunity supports innovative educational projects that inspire pre-college students to pursue careers in STEM, particularly in biomedical and behavioral sciences, through engaging activities in both classroom and informal settings.

Education
State governments
Supporting life-saving HIV services and related health systems in Zambia on a pathway to self-reliance under the Presidents Plan for AIDS Relief (PEPFAR)
Contact for amount
U.S. Department of Health and Human Services (Centers for Disease Control-GHC)
Federal

Application Deadline

Feb 17, 2026

Date Added

Oct 17, 2025

This funding opportunity provides financial support to a variety of organizations to enhance HIV prevention, care, and treatment services in Zambia, while strengthening the local health systems and promoting national ownership of these initiatives.

Health
State governments
Biological Technologies
$2,000,000
U.S. Department of Defense (DARPA - Biological Technologies Office)
Federal

Application Deadline

Sep 30, 2026

Date Added

Oct 2, 2025

This grant provides funding for innovative research projects that utilize biological technologies to enhance U.S. national security, targeting a wide range of applicants including nonprofits, educational institutions, and businesses.

Science and Technology
Nonprofits
Applied Mathematics
Contact for amount
National Science Foundation
Federal

Application Deadline

Nov 16, 2026

Date Added

Mar 17, 2025

This funding opportunity supports researchers in mathematics who are working on innovative solutions to scientific and engineering challenges, while also promoting the training of emerging applied mathematicians.

Science and Technology
Public and State controlled institutions of higher education
Catalytic Application Testing For Accelerated Learning Chemistries Via High-Throughput Experimentation And Modeling Efficiently (Catalchem-E)
$3,500,000
U.S. Department of Energy (Advanced Research Projects Agency Energy )
Federal

Application Deadline

Feb 25, 2026

Date Added

Nov 15, 2024

This funding opportunity supports innovative research teams in developing advanced catalysts for low-carbon fuels and chemicals, aiming to significantly accelerate the discovery and optimization process through high-throughput experimentation and artificial intelligence.

Science and Technology
Individuals
Targeted Genome Editor Delivery (TARGETED) Challenge
$1,000,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

May 4, 2026

Date Added

Dec 24, 2025

This grant provides funding to U.S.-based teams and entities to develop innovative delivery technologies for genome editing, focusing on improving treatment options for various diseases, particularly those affecting hard-to-reach tissues and the brain.

Science and Technology
Individuals
Science of Organizations
Contact for amount
National Science Foundation
Federal
Rolling

Application Deadline

Not specified

Date Added

Feb 18, 2024

This program provides funding for researchers to conduct scientific studies that improve our understanding of how organizations operate and evolve, benefiting both public and private sectors.

Science and Technology
Public and State controlled institutions of higher education
Injury Prevention and Control Research and State and Community Based Programs - RFA-SH-18-000
Contact for amount
U.S. Department of Health and Human Services (Centers for Disease Control and Prevention - ERA)
Federal

Application Deadline

Sep 30, 2030

Date Added

Oct 19, 2023

This funding opportunity provides financial support to a wide range of organizations, including state governments, universities, and nonprofits, to develop and implement programs focused on preventing injuries and promoting public health in communities across the U.S.

Health
State governments
Focused Technology Research and Development (R01 Clinical Trial Not Allowed)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jun 22, 2026

Date Added

Nov 15, 2024

This funding opportunity supports innovative projects that develop new tools and technologies to advance biomedical research, targeting a wide range of eligible applicants including universities, nonprofits, and businesses.

Health
State governments
Rfa-Tp-18-000
Contact for amount
U.S. Department of Health and Human Services (Centers for Disease Control and Prevention - ERA)
Federal

Application Deadline

Sep 30, 2030

Date Added

Nov 26, 2025

This funding opportunity provides financial support to a variety of organizations, including state governments, universities, and nonprofits, to implement innovative public health programs focused on preventing injuries and promoting safety in communities.

Health
State governments
Biophotonics
Contact for amount
National Science Foundation
Federal
Rolling

Application Deadline

Not specified

Date Added

Apr 5, 2023

This program provides funding for researchers to develop innovative photonics technologies that improve medical diagnostics and therapies, particularly in areas like deep tissue imaging and neural activation.

Science and Technology
Private institutions of higher education
Academic-Industrial Partnerships (AIP) to Translate and Validate In Vivo Imaging Systems (R01 Clinical Trial Optional)
$500,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Feb 5, 2026

Date Added

Nov 7, 2024

This funding opportunity supports collaborations between academic researchers and industry partners to develop and validate advanced imaging technologies that improve cancer detection and treatment.

Education
State governments
Chemical Screening and Optimization Facility (X01 Clinical Trial Not Allowed)
Contact for amount
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Apr 3, 2026

Date Added

May 19, 2023

This grant provides researchers with access to advanced facilities and technical support for developing non-hormonal contraception and reproductive health products, without direct funding.

Health
State governments
Long Range Broad Agency Announcement (LRBAA) 24-01
Contact for amount
U.S. Department of Homeland Security (DHS), Science and Technology Directorate (S&T)
Federal
Rolling

Application Deadline

May 31, 2029

Date Added

Mar 18, 2025

This grant invites industry and academic researchers to propose innovative solutions that enhance homeland security across various mission areas, including counterterrorism, cybersecurity, and public safety.

Science and Technology
For profit organizations other than small businesses
Reissue of RFA-FD-23-001- Clinical Studies of Orphan Products Addressing Unmet Needs of Rare Diseases (R01 Clinical Trials Required)
$900,000
U.S. Department of Health & Human Services (Food and Drug Administration)
Federal

Application Deadline

May 16, 2028

Date Added

Jul 12, 2025

This funding opportunity provides financial support for clinical trials aimed at developing new treatments for rare diseases affecting fewer than 200,000 people in the U.S., encouraging innovative trial designs and collaboration among various research entities.

Health
Public and State controlled institutions of higher education
ROSES 2025: Research Opportunities in Space and Earth Science
$5,000,000
National Aeronautics and Space Administration (NASA Headquarters)
Federal

Application Deadline

May 31, 2026

Date Added

Jul 12, 2025

This funding opportunity supports a wide range of research and technology development in Earth and space sciences, aimed at U.S.-based institutions, nonprofits, private entities, and government organizations, to advance NASA's strategic mission goals.

Science and Technology
Public and State controlled institutions of higher education
Glioblastoma Therapeutics Network (GTN; U19 Clinical Trial Required)
Contact for amount
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

May 27, 2026

Date Added

Sep 18, 2025

This funding opportunity supports diverse research teams in developing innovative therapies for adult glioblastoma, focusing on translating promising treatments into early clinical trials.

Health
State governments