Grants for Small Businesses

This Notice of Funding Opportunity (NOFO) aims to support research on interdisciplinary population approaches to increasing awareness of the relationship between alcohol and cancer risk, understanding and changing social norms related to alcohol consumption, developing and/or evaluating alcohol policy approaches, and the development, testing, and implementation of population-level interventions to reduce alcohol-related cancer risk. Applications that address multiple levels of consumption, such as moderate and heavy drinking, are of particular interest, as well as those focusing on alcohol use disorder (AUD) from the perspective of cancer prevention and control. Proposals addressing understudied areas are encouraged, as is attention to underrepresented minority (URM) populations experiencing cancer and alcohol-related disparities such as American Indian, Alaskan Native, and sexual and gender minority populations.

Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) solicits applications for identification of small molecules that function to elucidate the biology of disease as chemical probes or function as agonists or antagonists of disease target(s) for therapy or immunotherapy. The NOFO is intended to support discovery research for the identification of validated hits relevant to health-related outcomes of participating NIH Institutes. Stages of discovery research covered by this NOFO include: 1) assay development for specific biological targets and disease mechanisms relevant to the mission of participating NIH Institutes with the intent to screen for small molecule compounds that show potential as probes for use in advancing knowledge about the known targets, identifying new targets, or as pre-therapeutic leads; 2) screen implementation high throughput target-focused approaches or moderate throughput phenotypic- and fragment-based approaches to identify initial screening hits; 3) hit validation, including implementation of secondary assays that are orthogonal to the primary assay, advanced cheminformatics analysis and initial medicinal chemistry inspection to prioritize the hit set, and follow-up assays to characterize mode and mechanism of action of the validated hits; 4) hit-to-lead optimization, including SAR to optimize target engagement, selectivity and to minimize chemical liabilities, ADME, PK and PD studies, and, if appropriate, in vivo modeling to test efficacy or biological effects.

This funding opportunity supports experienced laboratory scientists engaged in cancer research within NCI-funded projects, providing salary support and travel funds to enhance their contributions without requiring them to become independent investigators.

This grant provides salary support for scientists with advanced degrees who contribute specialized expertise to NCI-funded cancer research programs within core facilities, promoting career stability without requiring independent investigator roles.

Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) intends to stimulate translation of scientific discoveries and engineering developments in imaging, data science and/or spectroscopic technologies into methods or tools that address contemporary problems in understanding the fundamental biology, potential risk of development, diagnosis, treatment, and/or disease status for cancer or other disease.

This program provides cash grants to companies planning significant projects in Texas that will create jobs and make substantial capital investments, incentivizing them to choose Texas over competing locations.

This initiative provides $500 micro-grants and entrepreneurial support to U.S.-based small business owners, helping them grow through funding, mentorship, and community resources.

This program provides $1,000 micro-grants to individuals and groups for creative and innovative projects that positively impact their communities.

UpStart Thrift Store will award competitive grants of up to $5,000 to small business owners in Washington County. The UpStart Thrift Store team will work with the Startup Junkie Foundation leadership to select the awardees based on the merits of their application. If your startup or small business could benefit from such a grant, fill out the application at the link below. Please don't apply unless your business is physically located in Washington County, Arkansas. The grant awards starting at $500 are provided by the sales proceeds derived from efforts of an all volunteer non-profit thrift store called Upstart Thrift that is a program of the 501c3, Startup Junkie Foundation. The intent is to provide a hand up to deserving small businesses in Washington County, Arkansas. Applicants will only be eligible for one award per calendar year. Applications will be reviewed quarterly. The top three candidates will be contacted to conduct a brief interview. Candidates who do not receive a grant are still eligible for funds via Kiva NWA and free consulting from Startup Junkie.

This program provides financial support and resources to help Black-owned businesses grow, acquire customers, and succeed on Amazon's platform through education, mentorship, and expert guidance.

This funding opportunity supports innovative educational programs that equip health professionals with the latest research and evidence-based practices related to alcohol and substance use disorders, enhancing patient care and addressing treatment disparities.

This funding opportunity provides financial support for researchers to analyze and integrate existing data to better understand cancer risk, prevention, and treatment outcomes, particularly focusing on innovative methodologies and addressing health disparities.

This funding opportunity supports institutions in creating collaborative training networks for early-career researchers focused on advancing studies in kidney, urologic, and hematologic diseases.

This funding opportunity supports research projects that improve medical and human performance capabilities for military personnel, focusing on innovative solutions for Special Operations Forces in challenging environments.

This funding opportunity provides financial assistance to bioscience start-ups, early-stage businesses, and academic institutions in Connecticut to help accelerate the commercialization of innovative bioscience breakthroughs.

This grant provides funding for research and development of innovative aerospace technologies to improve military air vehicle performance and capabilities.

This funding initiative provides financial support to Black-owned small businesses across the U.S. to help them sustain or rebuild their operations and foster local economic empowerment.

The National Institute of Mental Health (NIMH) intends to promote a new initiative by publishing a Notice of Funding Opportunity (NOFO) to solicit applications encouraging foundational research projects that seek to refine and test valid methods for characterizing preteen suicide risk and protective factors across multiple domains, and for operationalizing suicide thoughts and behavior (STBs) and nonsuicidal self-injury (NSSI) among preteen youth (ages 8-12). An emphasis is placed on the inclusion of sub-populations of youth that experience health disparities and may have been underrepresented in prior youth suicide research. Studies may focus on developing new or adapting developmentally and culturally appropriate methods for assessing and characterizing risk and protective factors, examining the acceptability and utility of existing assessment methods, evaluating the relevance of risk and protective factors for diverse preteen youth and their families, modeling risk-factor trajectories, and refining sampling strategies. The research projects funded through this announcement will participate in a research consortium with other R01 recipients. In addition, each research site will work with the Data Coordinating Center (DCC) site (supported by a companion announcement) to share and analyze data, recommend candidate measures that will be included as common data elements in future research and practice contexts,and identify optimal approaches for sampling individuals from underrepresented backgrounds. This Notice of Intent to Publish (NOITP) is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects, and to consult with NIH in order to submit responsive applications. The NOFO is expected to be published in Summer 2023, with an expected application due date in Fall 2023. This NOFO will utilize the R01 activity code. Details of the planned NOFO are provided below.

This program provides funding to public entities and private marina owners for the construction and improvement of recreational boating facilities specifically designed for transient vessels over 26 feet in length.

The Naval Air Warfare Center Aircraft Division (NAWCAD) is interested in receiving white papers for Research and Development projects which offer potential for advancement and improvement of NAWCAD operations. Research Opportunity Areas of Interest:  Aeromechanics. Areas of research include but are not limited to the following: aerodynamic and flight controls (manned and unmanned), aeromechanics modeling and analysis tools, flight performance, rotorcraft aerodynamics and performance, ship/aircraft aerodynamic interactions, and unmanned aviation and integration including pilot augmentation and automation and UAV autonomous landing flight mechanics.  Artificial Intelligence (AI) / Machine Learning (ML) (Priority). Areas of research include but are not limited to the following: Autonomous system development, testing, evaluation, verification and validation tools, airworthiness and risk quantification/acceptance, collaborative autonomy, complex reasoning, multiagent based operation and decision making, airspace integration including sense and avoid algorithms, deep reinforcement learning, neural networks, and demand forecasting.  Avionics, Sensors & Electronic Warfare: Areas of research include but are not limited to the following: passive/active sensor systems (RF, EO/IR, and acoustic), advanced/alternative precision navigation and timing (PNT), advanced computational/open system architectures, advanced signal and image processing, flight information and control systems, and advanced concepts in electronic warfare systems.  Cyber (Priority). Areas of research may include but are not limited to the following: cyber effects modeling, reverse engineering, behavioral analysis, intrusion, adaptive cybersecurity, simulation and interface research, concolic testing and systems configuration management. Page | 4  Data Science & Visualization. Areas of research include but are not limited to the following: predictive modeling algorithms, complex big-data environments, data access, storage and retrieval, data visualization techniques, risk assessment and uncertainty quantification, and statistical analysis.  Digital Engineering (Priority). Areas of research include but are not limited to the following: advancements in the use of Digital Twin technology and concepts to support predictive maintenance, automated sustainment environment, diagnostics and prognostics, predictive maintenance, digital communication of system requirements using model-based systems engineering (MBSE)/Systems Modeling Language (SysML) views, engineering models and virtual environments to test designs across broader parameters than what live testing permits  Human Systems. Areas of research include but are not limited to the following: human performance assessment and modeling, cognitive performance/workload, human-machine interface/teaming, protective equipment, controls and displays, ergonomics, anthropomorphic measurement, virtual environments, and human factor engineering (social, behavioral, health, and cultural).  Hypersonic Systems (Priority). Areas of research include but are not limited to the following: external and internal high-speed aerodynamic, multi-physic modeling and simulation, hypersonic system testing and evaluation, high temperature and specific strength materials, structures and coatings, guidance, navigation and control and advanced air-breathing propulsion.  Materials and Aircraft Structures. Areas of research include but are not limited to the following: additive manufacturing, corrosion prevention, non-destructive inspection, structural repair and repair processes for metals and ceramics, polymers and composites, analysis and simulation of aircraft structures, structural mechanics, fouling, low observable, high temperature material, low temperature icing resistant and life management of airframes.  Mechanical Systems. Areas of research include but are not limited to the following: fire and ice protection for aviation systems, fuel containment, hydraulic systems, pneumatic systems and landing gear systems analysis.  Power and Propulsion Systems. Areas of research include but are not limited to the following: reliability engineering, fuel systems, prognostics and diagnostics, energy storage/efficiency, air‐breathing engines, fuels and lubricants, electrical power generation, auxiliary power, low observable signature technologies, propulsion life management, and mechanical and drive systems. Page | 5  Quantum (Priority). Areas of research may include but are not limited to the following: secure communication and sensing capabilities, nitrogen vacancy diamond sensing, quantum encryption and quantum computing.  Secure Communications & Networks (Priority): Areas of research include but are not limited to the following: resilient data and communications networks for Command and Control, architecture, analysis and software development, information assurance including blockchain networks and security, platform/system health monitoring, effective data transfer of both communications and video and integration of security end to end in software development, all with consideration for autonomous applications, while performing in dynamic and contested environments.  Support Equipment. Areas of research include but are not limited to the following: launch and recovery equipment, electro‐magnetics, high‐energy generation and control, environmental sensing, prognostics and health monitoring, automatic testing of hardware and software, displays, advanced maintenance technologies, information systems and intelligent agents, and advanced computer and data processing applications.  Test and Evaluation Engineering. Areas of research include but are not limited to the following: telemetry, communications, data links and data acquisition, signature technologies, mission system testing, system of systems testing environments, virtual reality (VR), augmented reality (AR), extended reality (XR), target engineering, airborne threat simulation, integrated battle‐space simulation (Live Virtual Constructive Environments), hardware‐in‐the‐loop testing, flight instrumentation, ground radar analysis, test article configuration, navigation, and identification, manned-unmanned teaming, advance training systems to include instructional techniques and strategies, and game-based training.  Warfare Analysis. Areas of research include but are not limited to the following: operational suitability, signal extraction, clutter reduction, modeling and simulation, maritime effectiveness, vulnerability and capability based assessment, and conceptual aircraft design.